DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mdy and ARE2

DIOPT Version :9

Sequence 1:	NP_609813.1	Gene:	mdy / 44887	FlyBaseID:	FBgn0004797	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_014416.1	Gene:	ARE2 / 855753	SGDID:	S000005302	Length:	642	Species:	Saccharomyces cerevisiae

Alignment Length:	596	Identity:	121/596 - (20%)
Similarity:	232/596 - (38%)	Gaps:	165/596 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KVLDKDENGNGTN----GSEKKLRYRRTQS--------------------------------VTR 99
            :|::.|:|...|:    .|::|.|||:..|                                .|.
Yeast    88 EVIETDDNMFKTHVKTLSSKEKARYRQGSSNFISYFDDMSFEHRPSILDGSVNEPFKTKFVGPTL 152

  Fly   100 AEEISNKEEK---------QRRAQP------GR---------PIHRPRDSLFSWSSGF--TNFSG 138
            .:||..:|::         .|::.|      |:         |.....:::.:..:..  :||||
Yeast   153 EKEIRRREKELMAMRKNLHHRKSSPDAVDSVGKNDGAAPTTVPTAATSETVVTVETTIISSNFSG 217

  Fly   139 LVNWGFLLLCIGGLR-------------------------------------------LGLENLL 160
            |....::.:..|.::                                           :|::.|.
Yeast   218 LYVAFWMAIAFGAVKALIDYYYQHNGSFKDSEILKFMTTNLFTVASVDLLMYLSTYFVVGIQYLC 282

  Fly   161 KYGI-RINPLDWFFFISGHNEGEGHNALILSIYSLVHISLCL-AVEKGLAMEIIAEGLGLFIQIV 223
            |:|: :.....|.|               .|||..:.:...: ..|..|.:..:::   :|:.:.
Yeast   283 KWGVLKWGTTGWIF---------------TSIYEFLFVIFYMYLTENILKLHWLSK---IFLFLH 329

  Fly   224 NIVVLVCLPVVTIHLKGHAFSLMGASTVCFFYSVLFLKLWSYVQTNMWCRQTYYQKNPRERRPSI 288
            ::|:|         :|.|:|:         ||:..   ||...:...:.:....:.......|.:
Yeast   330 SLVLL---------MKMHSFA---------FYNGY---LWGIKEELQFSKSALAKYKDSINDPKV 373

  Fly   289 TLAELKKGV------LNGGEEDEDVSKLVQYPDNLTYKDLLYFLCAPTLCYELNFPRTSRVRKRF 347
             :..|:|..      |:.....:...|   :|:|::.|...:|...|||.|::.:|||..:|..:
Yeast   374 -IGALEKSCEFCSFELSSQSLSDQTQK---FPNNISAKSFFWFTMFPTLIYQIEYPRTKEIRWSY 434

  Fly   348 LLKRLLEVVIGVNVVMALFQQWIIPSVRNSLIPFSNMDVALATERLLKLA------LPNHL-CWL 405
            :|:::. .:.|...:|.:..|.::..|....:...|.:.....:||||..      :|..: .::
Yeast   435 VLEKIC-AIFGTIFLMMIDAQILMYPVAMRALAVRNSEWTGILDRLLKWVGLLVDIVPGFIVMYI 498

  Fly   406 CFFYLMFHSFLNAVGELLNFADRNFYCDWWNANNIDTFWRTWNMPVHRWCVRHLY-IPVVQMGYS 469
            ..|||::.:.||.|.||..|.||.||.||||..:...|.|.||:|||::.:||:| ..:.....:
Yeast   499 LDFYLIWDAILNCVAELTRFGDRYFYGDWWNCVSWADFSRIWNIPVHKFLLRHVYHSSMSSFKLN 563

  Fly   470 SRQASTIVFLFSAVFHEYLVSVPLQIYKIWAFMGMMGQIPLSAISKSIEKKLGPRMGNIIVWASI 534
            ..||:.:.|..|:|.||..:.|..:..:.:.|...|.|:||.|::.:...:....:||:|.|..|
Yeast   564 KSQATLMTFFLSSVVHELAMYVIFKKLRFYLFFFQMLQMPLVALTNTKFMRNRTIIGNVIFWLGI 628

  Fly   535 ILGQPLCIMAY 545
            .:|..:....|
Yeast   629 CMGPSVMCTLY 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdy	NP_609813.1	MBOAT	115..545	CDD:294479	105/505 (21%)
ARE2	NP_014416.1	ARE1	106..642	CDD:227389	117/578 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346674
Domainoid	1	1.000	127	1.000	Domainoid score	I1169
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.650022	Normalized mean entropy	S2132
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003134
OrthoInspector	1	1.000	-	-		otm46613
orthoMCL	1	0.900	-	-		OOG6_101524
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2034
SonicParanoid	1	1.000	-	-		X3023
TreeFam	0	0.000	Not matched by this tool.
	9	8.720