DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mdy and ARE1

DIOPT Version :9

Sequence 1:	NP_609813.1	Gene:	mdy / 44887	FlyBaseID:	FBgn0004797	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_009978.1	Gene:	ARE1 / 850415	SGDID:	S000000644	Length:	610	Species:	Saccharomyces cerevisiae

Alignment Length:	501	Identity:	129/501 - (25%)
Similarity:	223/501 - (44%)	Gaps:	82/501 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 KKLRYRRTQSVTRAEEISNKEEKQRRAQ--PGRPIHRPRDSLFSWSSGFTNFSGLVNWGFLLLCI 149
            |.|:..:|::....:......||..:|.  ||..:.             :||||:..:.::.|..
Yeast   148 KNLQLTKTKTKATVKTTVKTTEKTDKADAPPGEKLE-------------SNFSGIYVFAWMFLGW 199

  Fly   150 GGLRLGLENLLKYGIRINPLDWFFFISGHNEGEGHNALILSIYSLVHISLCL------------A 202
            ..:|...:....||...|.|:...:::            ..::::..:.|.:            .
Yeast   200 IAIRCCTDYYASYGSAWNKLEIVQYMT------------TDLFTIAMLDLAMFLCTFFVVFVHWL 252

  Fly   203 VEKGLAMEIIAEGLGLFIQIVNIVVLVCLPVVTIHLKGHAFSLMGASTV-CFFYSVLF-LKLWSY 265
            |:|    .||......|: .|:|..|..:| ||..:..:.|.....:.: .|.:||:| :|..|:
Yeast   253 VKK----RIINWKWTGFV-AVSIFELAFIP-VTFPIYVYYFDFNWVTRIFLFLHSVVFVMKSHSF 311

  Fly   266 VQTN--MW-CRQ--TYYQKNPRERRPSI---TLAELKKGV------LNGGEEDEDVSKLVQYPDN 316
            ...|  :| .:|  .|..|..::.:.|:   |...|:|..      ||...:|.|      :|:|
Yeast   312 AFYNGYLWDIKQELEYSSKQLQKYKESLSPETREILQKSCDFCLFELNYQTKDND------FPNN 370

  Fly   317 LTYKDLLYFLCAPTLCYELNFPRTSRVRKRFLLKRLLEVVIGVNVVMALFQQWIIPSVRNSLIPF 381
            ::..:...|...|.|.|::|:|||||:|.|::|:::. .:||...:|.:..|:.:..|....|.|
Yeast   371 ISCSNFFMFCLFPVLVYQINYPRTSRIRWRYVLEKVC-AIIGTIFLMMVTAQFFMHPVAMRCIQF 434

  Fly   382 SNMDV----ALATE---RLLKLALPNH-LCWLCFFYLMFHSFLNAVGELLNFADRNFYCDWWNAN 438
            .|...    ..||:   .||...:|.. :.::..||:::.:.||.|.||..||||.||.||||..
Yeast   435 HNTPTFGGWIPATQEWFHLLFDMIPGFTVLYMLTFYMIWDALLNCVAELTRFADRYFYGDWWNCV 499

  Fly   439 NIDTFWRTWNMPVHRWCVRHLYIPVVQMG---YSSRQASTIVFLFSAVFHEYLVSVPLQIYKIWA 500
            :.:.|.|.||:|||::.:||:|..  .||   .|..||:...|..||||||..:....:..:.:.
Yeast   500 SFEEFSRIWNVPVHKFLLRHVYHS--SMGALHLSKSQATLFTFFLSAVFHEMAMFAIFRRVRGYL 562

  Fly   501 FMGMMGQIPLSAISKSIEKKLGPRMGNIIVWASIILGQPLCIMAYY 546
            ||..:.|...:|:|.:...:..|::.|::....:..| |..||..|
Yeast   563 FMFQLSQFVWTALSNTKFLRARPQLSNVVFSFGVCSG-PSIIMTLY 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdy	NP_609813.1	MBOAT	115..545	CDD:294479	122/468 (26%)
ARE1	NP_009978.1	ARE1	96..610	CDD:227389	129/501 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346676
Domainoid	1	1.000	127	1.000	Domainoid score	I1169
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.650022	Normalized mean entropy	S2132
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003134
OrthoInspector	1	1.000	-	-		otm46613
orthoMCL	1	0.900	-	-		OOG6_101524
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2034
SonicParanoid	1	1.000	-	-		X3023
TreeFam	0	0.000	Not matched by this tool.
	9	8.720