DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mdy and are2

DIOPT Version :9

Sequence 1:	NP_609813.1	Gene:	mdy / 44887	FlyBaseID:	FBgn0004797	Length:	565	Species:	Drosophila melanogaster
Sequence 2:	NP_588558.1	Gene:	are2 / 2538854	PomBaseID:	SPCP1E11.05c	Length:	472	Species:	Schizosaccharomyces pombe

Alignment Length:	489	Identity:	129/489 - (26%)
Similarity:	210/489 - (42%)	Gaps:	78/489 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KLRYRRTQSVTRAEEISNKEEKQRRAQPGRPIHRPRDSLF--SWSSGFTNFSGLVNWGFLLLCIG 150
            |:..||:::..|..|:|                 |..|:|  ::.....:|:|.....::.:.|.
pombe    28 KIDLRRSRAAYRPLELS-----------------PTPSIFARNYQRNAVDFTGFFVLFWVAVSIM 75

  Fly   151 GLRLGLENLLKYGIRINPLDWFFFISGHNEGEGHNALILSIYSLVHISLCLAVEKGLA---MEII 212
            .....|||....|..:....:.:|.|        |.|.|:...|...|:.|     ||   .:|.
pombe    76 IFMSFLENFELTGRPVVGTIFKYFQS--------NLLDLAKADLAMSSMFL-----LAFPFQKIF 127

  Fly   213 AEG----LGLFIQIVNIVVLVCLPVVTIHLKGHAFSLMGASTVCFFYSVLFLKLWSYVQTNMWCR 273
            |.|    .||.:.:.:|::|:.|....:......:|....:.......|:.:||.||...|.|..
pombe   128 ALGYLRWYGLGVYLYSILILLFLSHCVLRCCLSNWSWTHRAMFILHSMVILMKLHSYNVVNGWYS 192

  Fly   274 QTYYQKNPRERRPSITLAELKKGVLNGGEEDEDVSKLVQ------------YPDNLTYKDLLYFL 326
            ..|:..|..:.:.:              :.|:|....|:            ||:|||..:.|.||
pombe   193 YCYHSLNKLQSKKT--------------DLDDDERSSVEFYEHCLNHHGNTYPENLTIPNALDFL 243

  Fly   327 CAPTLCYELNFPRTSRVRKRFLLKRLLEVVIGVNVVMALFQQWIIPSVRNSLIPFSNM-DVALAT 390
            ..|:|||:|.:|||:.||..:|::..|.....:.:::.:...:::|.:..::...... :.|.||
pombe   244 FMPSLCYQLYYPRTAHVRIHYLIECALGTFGCIFLLVIISDHFMVPVLAKAIRTIIEAPEDASAT 308

  Fly   391 ERLLKLA-------LPNHLCWLCFFYLMFHSFLNAVGELLNFADRNFYCDWWNANNIDTFWRTWN 448
            ...::|.       .|..|.:|..|:::|....|...|:..|||||||.||||....|.|.||||
pombe   309 YFAIRLGHTVAFLMFPFMLSFLLVFWVIFEGVCNFSAEITRFADRNFYDDWWNCWTWDQFARTWN 373

  Fly   449 MPVHRWCVRHLYIPVVQMGYSSRQAST-IVFLFSAVFHEYLVS-VPLQIYKIWAFMGMMGQIPLS 511
            .|||.:.:||:|:|:  ..:.|:..|| ..|..|:|.||.::. :.|:|.....|. .|.|||..
pombe   374 KPVHYFLLRHVYVPL--NSFMSKSLSTFFTFFVSSVLHELVMGCITLKIRGYGLFF-QMTQIPYI 435

  Fly   512 AISKSIEKKLGPRMGNIIVWASIILGQPLCIMAY 545
            .|.:....:....:|||..|.|||:|..|....|
pombe   436 IIQRQKFVRRHRLLGNIAFWFSIIIGIALIAALY 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdy	NP_609813.1	MBOAT	115..545	CDD:294479	122/460 (27%)
are2	NP_588558.1	ARE1	1..472	CDD:227389	129/489 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	134	1.000	Domainoid score	I1277
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I1408
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003134
OrthoInspector	1	1.000	-	-		mtm9286
orthoMCL	1	0.900	-	-		OOG6_101524
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2034
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890