DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and itgb8

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_021323878.1	Gene:	itgb8 / 556752	ZFINID:	ZDB-GENE-071213-3	Length:	719	Species:	Danio rerio

Alignment Length:	707	Identity:	233/707 - (32%)
Similarity:	356/707 - (50%)	Gaps:	83/707 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 QIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRIT 219
            |:.|:.:.:.||...:.:..|...|.|.||||||||:|:|.||:|:..:|.|:|..||..||:.:
Zfish    46 QVAPREITIHLRPGSEASFVIEVQQLERYPVDLYYLVDVSASMQDNLDRLKTVGLALSHQMKQHS 110

  Fly   220 NNFHLGFGSFVDKVLMPYVSTIPKNLVEPCA----NCTATYGFHHQMVLDKNITQFTNEVKNATV 280
            ::|.:||||||||.:.||:...|..|:.||:    :|...:||.|.:.:.:|:::||..::...:
Zfish   111 SDFRVGFGSFVDKPVSPYIDVHPSKLLNPCSEYEVHCRPAHGFIHVLPVTQNMSEFTRVIQEQRI 175

  Fly   281 SGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSP 345
            |||:|.|||||||::||..|:..||||.:|:.||:..||...|.|.|.||.|::.|:||.|||.
Zfish   176 SGNMDTPEGGFDAMLQATVCQKDIGWRPEAKHLLLVMTDQPSHLALDSKLAGIVVPHDGRCHLE- 239

  Fly   346 KGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVE 410
            ...|:.::..::|:::|:.:|:.:|:|..||||...|...||.||:.|.||...:|...:||:.:
Zfish   240 DNVYSQTSTMEHPTVAQLAEKLLENSIYSIFAVDHLQYQWYEDLVDLIPGSYVGRLFPKASNLKD 304

  Fly   411 LVKEEYRKISSSVEMKDNATGDVKITYF-----SSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQL 470
            ||.:.|:|:.|.||::.......:...|     :.|.........|||..::..|.|.|...:.:
Zfish   305 LVVQAYKKLLSDVEVQMELQDPQQAERFWVNVSAICPGGSSAAGNSKCSGVQPKQTVFFQLTVGM 369

  Fly   471 LKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANSCSGHGTSMCGICNC 535
            |.||....|....:.:.|||.||.:::::..||...|.:|     :.:.:||:
Zfish   370 LSCPAGSADQDVLMLVRPVGFNESVRVRIRQLCGSGCTDP-----KPEPSSCT------------ 417

  Fly   536 DDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCE 600
                      .:|:|         ||| :..:|..||.||.|.||.|.|..  :....|.||.||
Zfish   418 ----------TNASD---------SCR-EHRNTPVCSSRGVCRCGTCVCDS--SRFGNIYGKFCE 460

  Fly   601 CDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECG 665
            .|:|||..:...:|.|  ||.|..|.|.|..||||..|.|:||.|:|: ...|.||...|.|.||
Zfish   461 MDDFSCPYDGGLVCGG--HGRCVRGECVCFSGWTGEACACRESTDSCV-SDDGFICGDRGRCVCG 522

  Fly   666 VCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKN--GDDCARNCTQFVPVGVE 728
            .|.|   |..|.||..|||||.|...||...:||.|      .|.|  |.|..:.|.|.....|:
Zfish   523 KCVC---DDPRRSGAFCEKCPMCHSSCQSHWNCVNC------HLSNGLGSDGFQLCNQSCSPLVD 578

  Fly   729 KV-EIDETKDEQMCKFFDEDDCKFMFKY---SEQGELH-------VYAQENKECPAKVFMLGIVM 782
            .| :|.|....:.|.:...|.|::.|..   |:..:||       |:::...:....||:|.:.:
Zfish   579 YVDDITELVRGKYCLYPSTDKCQYRFLMELASDGAQLHISRHPVCVWSRRYFKTFLSVFLLTVTL 643

  Fly   783 GVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFK 839
            |:   .:|.|:..||      .:..|...::.|.:..:...|:...|...:.|.|::
Zfish   644 GI---GMLAGVRQLL------RVTGRSCISKTEPQFEHTHKDSSYVPTSSEKTITYR 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	131/358 (37%)
		Integrin_B_tail	692..773	CDD:285239	23/93 (25%)
		Integrin_b_cyt	803..843	CDD:285884	6/37 (16%)
itgb8	XP_021323878.1	vWFA	9..402	CDD:320736	129/356 (36%)
		EGF_2	466..496	CDD:285248	13/31 (42%)
		Integrin_B_tail	546..624	CDD:311770	22/83 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020