DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and itgb1a

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_017209323.1	Gene:	itgb1a / 556734	ZFINID:	ZDB-GENE-060803-2	Length:	802	Species:	Danio rerio

Alignment Length:	870	Identity:	366/870 - (42%)
Similarity:	481/870 - (55%)	Gaps:	108/870 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLMIAILAAIA----GQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWCMQPDFKGQ---- 66
            |.||.|:.|..|.    .|.:..:..|..|:|       |..|||. :.|.||...:|..|
Zfish     3 LKLLFISALLGIISCSHAQQEGNECIKANALS-------CGECIQVGDKCGWCTDAEFLKQGEPT 60

  Fly    67 -SRCYQNTSSL----CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSS 126
             :|| ....||    |.|:...:|...::||.|..:||:.|
Zfish    61 SARC-DELESLKKRGCAEDKIENPHGSQRILKNTPVTNRKK------------------------ 100

  Fly   127 SSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLM 191
                             |.|:....:|.|||||.:.|.||..|..|||:.:.:||.||:||||||
Zfish   101 -----------------GAEKLRPEDITQIQPQKLSLQLRSGEPQNIKLKFKRAEDYPIDLYYLM 148

  Fly   192 DLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCA---NCT 253
            |||.||:||...:..||..|.:.|.:||::|.:||||||:|.:|||:||.|..|:.||.   |||
Zfish   149 DLSYSMKDDLENVKNLGTSLMKEMSKITSDFRIGFGSFVEKTVMPYISTTPAKLLNPCTGDQNCT 213

  Fly   254 ATYGFHHQMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFST 318
            :.:.:.:.:.|..|..:|.:.|....:|||||:||||||||||...|...|||| ...|||||||
Zfish   214 SPFSYKNVLKLTSNGQRFNSLVGQQQISGNLDSPEGGFDAIMQVAVCGEHIGWR-NVTRLLVFST 277

  Fly   319 DAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQL 383
            |||||:||||||||::.||||.|||. ...||.|...|||||:.:.||:.:|.|..|||||....
Zfish   278 DAGFHFAGDGKLGGIVLPNDGRCHLE-NDMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQ 341

  Fly   384 SVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLSNG-- 445
            .||::|...|..|:...|..:||||:.|:.:.|..:||.|.::::...: |.|||.|.| .||
Zfish   342 PVYKELKNLIPKSAVGTLSANSSNVINLIVDAYNSLSSEVILENSKLPEGVTITYQSRC-KNGVV 405

  Fly   446 PEVQTS-KCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCEN 509
            .|.::. ||.|:..|.:|||...|....||:..:  |:||.|.|:|..|.::|.|:.:|.|.|..
Zfish   406 NEGESGRKCSNISIGDEVSFNINITAQGCPKQGK--TETIKIKPLGFTEEVEITLSFICECECHK 468

  Fly   510 PGSIGYQVQANS--C-SGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDC 571
                  ....||  | :|:|:..||.|.|:....|.:|||...:::::.. |.:||.|: .|..|
Zfish   469 ------HAMKNSPLCHNGNGSFECGACRCNKGRVGRQCECRKDEVSTEDL-DKNCRKDN-GTDIC 525

  Fly   572 SGRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGS 636
            |..|.||||.|||.||.||.|..|||:||||||:|:|:.|:||.|  ||.|||..|.|...:|||
Zfish   526 SNNGECVCGTCECKKRENPEERYSGKYCECDNFNCDRSNNKLCGG--HGRCECRVCVCDANYTGS 588

  Fly   637 NCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQC 701
            .|.|.....||: ....:||:|.|.||||.|:||   ..:|.|..||.||||.|.|.|.|:||||
Zfish   589 ACDCSLDTSTCL-ASNKQICNGRGICECGTCRCT---DPKFQGPTCEICPTCPGVCTEHKECVQC 649

  Fly   702 QMYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQ--------MCKFFDEDDCKFMFKY--S 756
            :.:.|||.|  |.|.|:|:.|..:.||    |..|..|        .||..|..||.|.:.|  :
Zfish   650 RAFGTGEKK--DTCKRDCSYFNLIEVE----DRDKLPQPVQAFPLMHCKERDARDCWFYYTYAVN 708

  Fly   757 EQGELHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNA 821
            ...|..|:..:..|||....::.||.||:|.|||:|||:||:||||..||||||||:||||:|||
Zfish   709 NNTEKEVHVVKTMECPPGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNA 773

  Fly   822 KWDTGENPIYKQATSTFKNPMYAGK 846
            ||||.||||||...:.|:||.|..|
Zfish   774 KWDTTENPIYKSPINKFQNPNYGRK 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	192/476 (40%)
		Integrin_B_tail	692..773	CDD:285239	32/90 (36%)
		Integrin_b_cyt	803..843	CDD:285884	28/39 (72%)
itgb1a	XP_017209323.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I1974
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22999
Inparanoid	1	1.050	641	1.000	Inparanoid score	I795
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	1	1.000	-	-		otm25155
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	LDO	PTHR10082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2712
SonicParanoid	1	1.000	-	-		X739
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870