DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and ITGB8

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_002205.1	Gene:	ITGB8 / 3696	HGNCID:	6163	Length:	769	Species:	Homo sapiens

Alignment Length:	826	Identity:	257/826 - (31%)
Similarity:	377/826 - (45%)	Gaps:	159/826 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LERNRRCQLALLMIAILAAIA---GQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWCMQPDF 63
            |:.:||...:.|..|.:.::.   ||.:..:.|...|.|       |..|:.. ..|.||:|.||
Human    16 LQNDRRGPASFLWAAWVFSLVLGLGQGEDNRCASSNAAS-------CARCLALGPECGWCVQEDF 73

  Fly    64 -KGQSRCYQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSS 127
             .|.||     |..|.             :|:|.::                .|.|..|.
Human    74 ISGGSR-----SERCD-------------IVSNLIS----------------KGCSVDSI----- 99

  Fly   128 SSSFYSQSSSGSSSASGYEEYSAGEIV---------QIQPQSMRLALRVNEKHNIKISYSQAEGY 183
                               ||.:..::         |:.|..:.:.||...:.|..:.....:.|
Human   100 -------------------EYPSVHVIIPTENEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKY 145

  Fly   184 PVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEP 248
            |||||||:|:|.||.::..||:::|:.||..|...:.:|.|||||:|||.:.||:|..|:.:...
Human   146 PVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHPERIHNQ 210

  Fly   249 CA----NCTATYGFHHQMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQ 309
            |:    :|...:|:.|.:.|.:|||:|...|....:|||:|.|||||||::||..|.|.||||::
Human   211 CSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIGWRKE 275

  Fly   310 ARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINI 374
            |:|||:..||...|.|.|.||.|::.||||.|||. ...|..||..::||:.|:::|:.||.||:
Human   276 AKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLK-NNVYVKSTTMEHPSLGQLSEKLIDNNINV 339

  Fly   375 IFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMK-DNATGDVKITYF 438
            ||||...|...|:.|:..:.|:.|.::::.::|:..||.|.|:|:.|.|::: :|....:.....
Human   340 IFAVQGKQFHWYKDLLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNIT 404

  Fly   439 SSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLC 503
            :.|.....:.....|.|:....:|.|...:.:.||  |.........|.|:|.||..:|.:...|
Human   405 AICPDGSRKPGMEGCRNVTSNDEVLFNVTVTMKKC--DVTGGKNYAIIKPIGFNETAKIHIHRNC 467

  Fly   504 SCPCE-NPGSIGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTS 567
            ||.|| |.|..|..|......    |.|  ..||:    |||.......:|:     ||::....
Human   468 SCQCEDNRGPKGKCVDETFLD----SKC--FQCDE----NKCHFDEDQFSSE-----SCKSHKDQ 517

  Fly   568 TTDCSGRGHCVCGACECHKRPNPIEI--ISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCK 630
            .. |||||.||||.|.|||    |::  :.||:||.|:|||..:...||:|  ||.||.|||:|.
Human   518 PV-CSGRGVCVCGKCSCHK----IKLGKVYGKYCEKDDFSCPYHHGNLCAG--HGECEAGRCQCF 575

  Fly   631 PGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQEL 695
            .||.|..|.|..:.........|::|||.|||.||.|:||   ..|..||.||.||||...|:|.
Human   576 SGWEGDRCQCPSAAAQHCVNSKGQVCSGRGTCVCGRCECT---DPRSIGRFCEHCPTCYTACKEN 637

  Fly   696 KDCVQCQMYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGE 760
            .:|:||                    ..|..:.:..:|:      ||    ..|..|       |
Human   638 WNCMQC--------------------LHPHNLSQAILDQ------CK----TSCALM-------E 665

  Fly   761 LHVYAQENKECPAKVFMLGIVMGVIAAIVLVGL-------AILLLW 799
            ...|..:..||.:....|.|...:.....|:||       .::|.|
Human   666 QQHYVDQTSECFSSPSYLRIFFIIFIVTFLIGLLKVLIIRQVILQW 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	148/475 (31%)
		Integrin_B_tail	692..773	CDD:285239	15/80 (19%)
		Integrin_b_cyt	803..843	CDD:285884
ITGB8	NP_002205.1	INB	54..469	CDD:197563	149/482 (31%)
ITGB8	NP_002205.1	Cysteine-rich tandem repeats	471..629		72/182 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920