DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mys and ITGB7

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_000880.1	Gene:	ITGB7 / 3695	HGNCID:	6162	Length:	798	Species:	Homo sapiens

Alignment Length:	878	Identity:	308/878 - (35%)
Similarity:	448/878 - (51%)	Gaps:	134/878 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLMIAILAAIAGQTDAQKAAK--------------LTAVSTCASKEKCHTCIQTE-GCAWCMQ 60
            :||.|:.:|..:..:.:::..||              |:.:.:|.....|..||.:. .||||.|
Human     2 VALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQ 66

  Fly    61 PDF--KGQS---RCYQNTSSL---CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGS 117
            .:|  .|::   ||.:....|   ||.|....|...:::|.:..|
Human    67 LNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPL-------------------- 111

  Fly   118 SSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEG 182
                           ||.:.|..:            .|:.||.:|:.||..|...:::.:.:|||
Human   112 ---------------SQGARGEGA------------TQLAPQRVRVTLRPGEPQQLQVRFLRAEG 149

  Fly   183 YPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVE 247
            ||||||||||||.||:||..::..||..|...::.:|::..:||||||||.::|:|||:|..|..
Human   150 YPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRH 214

  Fly   248 PC----ANCTATYGFHHQMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWRE 308
            ||    ..|.:.:.|||.:.|..:...|..||...:||||||:||||||||:||..|:.|||||
Human   215 PCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWR- 278

  Fly   309 QARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAIN 373
            ...|||||::|..||.||||||||:..|:||.|||...|.|:.||..||||:.|:.|.:....|.
Human   279 NVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQ 343

  Fly   374 IIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNA-TGDVKITY 437
            .|||||::.|.||::|.:.|..|:..:|..||||||:|:.:.|..:||:|.::.:: ...|.|:|
Human   344 PIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISY 408

  Fly   438 FSSCLSNGPEVQTSK------CDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQ 496
            .|.|  .|||.:..|      |::::..|.|:|...:|...|..:|    ..:.:..:|.:|.:.
Human   409 ESQC--EGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLPEP----HLLRLRALGFSEELI 467

  Fly   497 IQLTMLCSCPCENPGSIGYQVQANSCS-GHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTS 560
            ::|..||.|.|.:.     |.||..|| |.|...||:|:|.....|..||||..:|:|... ::.
Human   468 VELHTLCDCNCSDT-----QPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDL-ESG 526

  Fly   561 CRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECG 625
            |||.:.:...|||:|||.||.|.|..:.      ||..||||:.||||:...||.|  .|.|:||
Human   527 CRAPNGTGPLCSGKGHCQCGRCSCSGQS------SGHLCECDDASCERHEGILCGG--FGRCQCG 583

  Fly   626 RCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSG 690
            .|.|....||..|.|....|:|:.|.|| :|||||.|:|..|:|.    ..:.|..|::||.|..
Human   584 VCHCHANRTGRACECSGDMDSCISPEGG-LCSGHGRCKCNRCQCL----DGYYGALCDQCPGCKT 643

  Fly   691 RCQELKDCVQCQMYKTGELKNGDDCARNCTQ------FVPVGVEKVEIDETKDEQMCKFFDEDDC 749
            .|:..:||.:|..::||.|  ..:|:..|..      ..|:..:....:.|.|.|:..|..|||.
Human   644 PCERHRDCAECGAFRTGPL--ATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDA 706

  Fly   750 K----FMFKYSEQGELHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRRE 810
            :    ...:..|:|..|..|              ||:|.:..||.|||.::|.::|...|:||||
Human   707 RGTVVLRVRPQEKGADHTQA--------------IVLGCVGGIVAVGLGLVLAYRLSVEIYDRRE 757

  Fly   811 FARFEKERMNAKWDTGENPIYKQATSTFKNPMY 843
            ::|||||:....|....||:||.|.:|..||.:
Human   758 YSRFEKEQQQLNWKQDSNPLYKSAITTTINPRF 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	175/479 (37%)
		Integrin_B_tail	692..773	CDD:285239	21/90 (23%)
		Integrin_b_cyt	803..843	CDD:285884	19/39 (49%)
ITGB7	NP_000880.1	INB	50..476	CDD:197563	175/479 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..124		7/72 (10%)
		Cysteine-rich tandem repeats	478..640		72/180 (40%)
		VESA1_N	537..>645	CDD:289551	52/120 (43%)
		EGF_2	607..635	CDD:285248	13/32 (41%)
		Integrin_B_tail	645..717	CDD:285239	17/73 (23%)
		Integrin_b_cyt	750..791	CDD:285884	19/41 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1947
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	648	1.000	Inparanoid score	I800
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	1	1.000	-	-		otm41588
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840