Protein Alignment mys and ITGB4

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_006721929.1
• Gene: ITGB4 / 3691
• HGNCID: 6158
• Length: 1910
• Species: Homo sapiens
• Alignment Length: 839
• Identity: 267/839 - (31%)
• Similarity: 403/839 - (48%)
• Gaps: 140/839 - (16%)

  Fly     4 ERNRRCQLA---------LLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTE-GCAWC 58
            :..||.::|         ||:.|:::.....|.|.:..|       |..:.|..|::.: .||:|
Human    29 QEGRRKRMAGPRPSPWARLLLAALISVSLSGTLANRCKK-------APVKSCTECVRVDKDCAYC 86

  Fly    59 MQPDFKGQSRCYQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGG--GGSAMSGSSSSS 121
            ....|:.: ||  ||                            :|||.|.|  ..|.:...||..
Human    87 TDEMFRDR-RC--NT----------------------------QAELLAAGCQRESIVVMESSFQ 120

  Fly   122 YSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVD 186
            .:..:...:...:|                   |:.||.:|:.||..|:.:.::...:....|||
Human   121 ITEETQIDTTLRRS-------------------QMSPQGLRVRLRPGEERHFELEVFEPLESPVD 166

  Fly   187 LYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCEN 251
            ||.|||.|.||.||...|..:|..|:..:.::|:::.:|||.|||||.:|.....|:||:.|..|
Human   167 LYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPN 231

  Fly   252 CKAPYGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVF 316
            ...|:.::|.:.|..:.:.|.|:::...:||||||||||||||:|...|...||||..:..||||
Human   232 SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVF 296

  Fly   317 STDAGFHYAGDGK--LGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVT 379
            ||::.|||..||.  |.|:::.||..|||...|.||....|||||:..:.:.:..:.|..|||||
Human   297 STESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVT 361

  Fly   380 ASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMK--DNATG---DVKITYFS 439
            ....|.||||..:...||...|..||||:|||::|.:.:|.|:::::  |:..|   :|....|.
Human   362 NYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQ 426

  Fly   440 SCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLK-------C--PEDPRDWTQTIHISPVGINEVM 495
                   :.:|... :::.|:...:..|::.|:       |  |||.:.   .||:.| ..::.:
Human   427 -------KTRTGSF-HIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKG---NIHLKP-SFSDGL 479

  Fly   496 QIQLTMLCS-CPCENPGSIGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDT 559
            ::...::|. |.||    :..:|::..||.:|..:||.|.|.:.:.|..|.||    |...::..
Human   480 KMDAGIICDVCTCE----LQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCS----TGSLSDIQ 536

  Fly   560 SCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCEC 624
            .|..:. ....|||||.|.||.|.|:....    ..|:.||.|||.|.|....||:  |.|.|..
Human   537 PCLREG-EDKPCSGRGECQCGHCVCYGEGR----YEGQFCEYDNFQCPRTSGFLCN--DRGRCSM 594

  Fly   625 GRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCE--KCPT 687
            |:|.|:|||||.:|.|..||.||:...|| ||:|.|.||||.|.|  :.|..::...||  ....
Human   595 GQCVCEPGWTGPSCDCPLSNATCIDSNGG-ICNGRGHCECGRCHC--HQQSLYTDTICEINYSAI 656

  Fly   688 CSGRCQELKDCVQCQMYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQ----MCKFFDE-D 747
            ..|.|::|:.|||||.:.||| |.|..| ..|...|.:      :||.|..:    .|.|.|| |
Human   657 HPGLCEDLRSCVQCQAWGTGE-KKGRTC-EECNFKVKM------VDELKRAEEVVVRCSFRDEDD 713

  Fly   748 DCKFMFKYSEQGE------LHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWK 800
            ||  .:.|:.:|:      ..|...:.|:||...|...|.: ::..:.|:.|.:||.||
Human   714 DC--TYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPL-LLLLLPLLALLLLLCWK 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	148/479 (31%)
		Integrin_B_tail	692..775	CDD:462325	31/93 (33%)
		Integrin_b_cyt	803..843	CDD:462580
ITGB4	XP_006721929.1	INB	72..488	CDD:197563	147/477 (31%)
		I-EGF_1	492..520	CDD:465729	10/31 (32%)
		EGF_2	585..608	CDD:400365	13/24 (54%)
		Integrin_B_tail	661..744	CDD:462325	31/92 (34%)
		Calx-beta	1025..1119	CDD:397326
		fn3	1163..1243	CDD:394996
		fn3	1256..1344	CDD:394996
		fn3	1617..1699	CDD:394996
		fn3	1730..1815	CDD:394996