DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and ITGB2

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_000202.3	Gene:	ITGB2 / 3689	HGNCID:	6155	Length:	769	Species:	Homo sapiens

Alignment Length:	854	Identity:	306/854 - (35%)
Similarity:	438/854 - (51%)	Gaps:	115/854 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWCMQPDFKGQS-----RC 69
            |||:.:..|..:.    :|:..|....|       |..||:: .||.||.:.:|.|..     ||
Human     9 LALVGLLSLGCVL----SQECTKFKVSS-------CRECIESGPGCTWCQKLNFTGPGDPDSIRC 62

  Fly    70 YQNTSSLCPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQ 134
                            .|..|:|                     |.|.::......
Human    63 ----------------DTRPQLL---------------------MRGCAADDIMDP--------- 81

  Fly   135 SSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMED 199
                :|.|...|:::.|: .|:.||.:.|.||..:.....:::.:|:|||:|||||||||.||.|
Human    82 ----TSLAETQEDHNGGQ-KQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLD 141

  Fly   200 DKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCAN----CTATYGFHH 260
            |...:..||..|...:..||.:..:||||||||.::|:|:|.|..|..||.|    |...:.|.|
Human   142 DLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRH 206

  Fly   261 QMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYA 325
            .:.|..|..||..||....:||||||||||.||:||..||..:|||| ...|||||:||.|||:|
Human   207 VLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWR-NVTRLLVFATDDGFHFA 270

  Fly   326 GDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLV 390
            ||||||.::.||||.|||. ...|..|...||||:.|:..|:.:|.|..|||||:..:..||||.
Human   271 GDGKLGAILTPNDGRCHLE-DNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLT 334

  Fly   391 EHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLSNGPEVQT---S 451
            |.|..|:..:|..||||||.|:|..|.|:||.|.:..||..| :|:||.|.| |||...:.   .
Human   335 EIIPKSAVGELSEDSSNVVHLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFC-SNGVTHRNQPRG 398

  Fly   452 KCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQ 516
            .||.::....::|..::...:|.::     |:..|..:|..:::.:|:...|.|.|.:...
Human   399 DCDGVQINVPITFQVKVTATECIQE-----QSFVIRALGFTDIVTVQVLPQCECRCRDQSR---- 454

  Fly   517 VQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGA 581
             ..:.|.|.|...||||.||..|.|..|||.....:|: ..:.|||.|:.|.. |||.|.||||.
Human   455 -DRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQ-ELEGSCRKDNNSII-CSGLGDCVCGQ 516

  Fly   582 CECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDT 646
            |.||....|.::|.|::||||..:|||...|:|.||..|.|.||:|:|.||:.||.|.|:.:.:.
Human   517 CLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEG 581

  Fly   647 CMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRH---CEKCPTCSGRCQELKDCVQCQMYKTGE 708
            |:.|...| |||.|.|.|.||:|       .||..   |::||.|...|.:...|.:|..::.|.
Human   582 CLNPRRVE-CSGRGRCRCNVCEC-------HSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGP 638

  Fly   709 LKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGELH---VYAQENKE 770
            .      .:||:...| |:: :..:..|. :.||..|.:.|...:...:|..:.   :|..|::|
Human   639 F------GKNCSAACP-GLQ-LSNNPVKG-RTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRE 694

  Fly   771 CPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQAT 835
            |.|...:..||.|.:|.|||:|:.:|::||.|..:.|.||:.|||||::.::|: .:||::|.||
Human   695 CVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWN-NDNPLFKSAT 758

  Fly   836 STFKNPMYA 844
            :|..||.:|
Human   759 TTVMNPKFA 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	173/473 (37%)
		Integrin_B_tail	692..773	CDD:285239	18/83 (22%)
		Integrin_b_cyt	803..843	CDD:285884	17/39 (44%)
ITGB2	NP_000202.3	INB	32..447	CDD:197563	174/480 (36%)
		Cell attachment site. /evidence=ECO:0000255	397..399		0/1 (0%)
		Cysteine-rich tandem repeats	449..617		74/182 (41%)
		Integrin_B_tail	622..699	CDD:311770	19/85 (22%)
		Integrin_b_cyt	726..767	CDD:312304	18/41 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	648	1.000	Inparanoid score	I800
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	1	1.000	-	-		otm41588
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X739
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.980