DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and ITGB1

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_391988.1	Gene:	ITGB1 / 3688	HGNCID:	6153	Length:	801	Species:	Homo sapiens

Alignment Length:	865	Identity:	360/865 - (41%)
Similarity:	476/865 - (55%)	Gaps:	110/865 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWC-----MQPDFKGQSRCYQNT 73
            :|:.:..:..|||..:..|       |:.:.|..|||. ..|.||     :|......:|| .:.
Human    11 LISSVCCVFAQTDENRCLK-------ANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARC-DDL 67

  Fly    74 SSL----CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQ 134
            .:|    ||.:...:|...:.|..|..:||:.|        |:|
Human    68 EALKKKGCPPDDIENPRGSKDIKKNKNVTNRSK--------GTA--------------------- 103

  Fly   135 SSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMED 199
                       |:....:|.|||||.:.|.||..|.....:.:.:||.||:|||||||||.||:|
Human   104 -----------EKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKD 157

  Fly   200 DKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCA---NCTATYGFHHQ 261
            |...:.:||..|...|:|||::|.:||||||:|.:|||:||.|..|..||.   |||:.:.:
Human   158 DLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSY--- 219

  Fly   262 MVLDKNITQFTN--EVKNATV-----SGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTD 319
                ||:...||  ||.|..|     |||||:||||||||||...|.|.|||| ...||||||||
Human   220 ----KNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWR-NVTRLLVFSTD 279

  Fly   320 AGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLS 384
            ||||:||||||||::.||||:|||. ...||.|...|||||:.:.||:.:|.|..|||||.....
Human   280 AGFHFAGDGKLGGIVLPNDGQCHLE-NNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQP 343

  Fly   385 VYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLS--NGP 446
            ||::|...|..|:...|..:||||::|:.:.|..:||.|.:::....: |.|:|.|.|.:  ||.
Human   344 VYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGT 408

  Fly   447 EVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPG 511
            .....||.|:..|.:|.|...|...|||:...|   :..|.|:|..|.:::.|..:|.|.|::.|
Human   409 GENGRKCSNISIGDEVQFEISITSNKCPKKDSD---SFKIRPLGFTEEVEVILQYICECECQSEG 470

  Fly   512 SIGYQVQANSC-SGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRG 575
            .    .::..| .|:||..||.|.|::...|..||||..::.|: ..|..||.:::|.. ||..|
Human   471 I----PESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSE-DMDAYCRKENSSEI-CSNNG 529

  Fly   576 HCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGC 640
            .||||.|.|.||.|..||.|||.||||||:|:|:...:|.|  :|.|:|..|:|.|.:|||.|.|
Human   530 ECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGG--NGVCKCRVCECNPNYTGSACDC 592

  Fly   641 QESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYK 705
            .....|| ....|:||:|.|.|||||||||   ..:|.|:.||.|.||.|.|.|.|:||||:.:.
Human   593 SLDTSTC-EASNGQICNGRGICECGVCKCT---DPKFQGQTCEMCQTCLGVCAEHKECVQCRAFN 653

  Fly   706 TGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQM-------CKFFDEDDCKFMFKYSEQG--EL 761
            .||.|  |.|.:.|:.|   .:.|||..:...:.:       ||..|.|||.|.|.||..|  |:
Human   654 KGEKK--DTCTQECSYF---NITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEV 713

  Fly   762 HVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTG 826
            .|:..||.|||....::.||.||:|.|||:|||:||:||||..||||||||:||||:|||||||.
Human   714 MVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTQ 778

  Fly   827 ENPIYKQATSTFKNPMYAGK 846
            ||||||...:.||||.|..|
Human   779 ENPIYKSPINNFKNPNYGRK 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	188/482 (39%)
		Integrin_B_tail	692..773	CDD:285239	34/89 (38%)
		Integrin_b_cyt	803..843	CDD:285884	29/39 (74%)
ITGB1	NP_391988.1	Integrin_beta	34..464	CDD:278776	188/482 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..107		11/71 (15%)
		CX3CL1-binding. /evidence=ECO:0000269\|PubMed:23125415	207..213		1/5 (20%)
		CX3CL1-binding. /evidence=ECO:0000269\|PubMed:24789099	295..314		10/19 (53%)
		Cysteine-rich tandem repeats	466..635		79/180 (44%)
		Integrin_B_tail	640..727	CDD:285239	35/91 (38%)
		Integrin_b_cyt	757..796	CDD:285884	29/38 (76%)
		Signal for sorting from recycling endosomes, interaction with ACAP1	762..767		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1947
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22999
Inparanoid	1	1.050	648	1.000	Inparanoid score	I800
Isobase	1	0.950	-	0	Normalized mean entropy	S3795
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	1	1.000	-	-		otm41588
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	LDO	PTHR10082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2712
SonicParanoid	1	1.000	-	-		X739
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820