DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and Itgb6

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001004263.1	Gene:	Itgb6 / 311061	RGDID:	1303119	Length:	787	Species:	Rattus norvegicus

Alignment Length:	859	Identity:	305/859 - (35%)
Similarity:	452/859 - (52%)	Gaps:	112/859 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLMIAILAAIAGQTDAQKAAKLTAVSTCA--SKEKCHTCIQT-EGCAWCMQPDFKGQS----R 68
            :.:.::.:...:.|:.|..:..       ||  ..|.|..|:.| ..||||.|.:|...|    |
  Rat     1 MGIELVCLFLLLLGRNDHVQGG-------CAWSGAETCSDCLLTGPHCAWCSQENFTHLSGAGER 58

  Fly    69 CYQNTSSL---CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSS 130
            |....:.|   |...|..:|::..:||.|..|                       |.....:||
  Rat    59 CDTPENLLAKGCQLPFIENPVSQVEILQNKPL-----------------------SVGRQKNSS- 99

  Fly   131 FYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSK 195
                                 :||||.|||:.|.||...:..:::...|.|.||||||||||||.
  Rat   100 ---------------------DIVQIAPQSLVLKLRPGGEQTLQVQVRQTEDYPVDLYYLMDLSA 143

  Fly   196 SMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCAN----CTATY 256
            ||:||...:..||.:|::.|.::|:||.|||||||:|.:.|::.|.|:.:..||::    |..|:
  Rat   144 SMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTF 208

  Fly   257 GFHHQMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAG 321
            ||.|.:.|..:..:|...|:...:|.|:|.|||||||||||..|:.:||||..:..||||.:||.
  Rat   209 GFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDAD 273

  Fly   322 FHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVY 386
            .|:..|.||.|::.||||.|||..:.||:.||:.:||:|.|:..|:..|.:.:|||||..|:.:|
  Rat   274 SHFGMDSKLAGIVIPNDGLCHLDNRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLY 338

  Fly   387 EKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD---VKITYFSSCLSNG--- 445
            |...:.|.|::...|..||.|:::|:...|.::.|.||::  ..||   :.:::.:.| |||
  Rat   339 ENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELE--VLGDTEGLNLSFTALC-SNGILF 400

  Fly   446 PEVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENP 510
            |  ...||.::|.|...||...:.:..|.:..|    .:.|.|||:.:.::|.::..|.|.|:.
  Rat   401 P--HQKKCSHMKVGDTASFNVSVSITNCEKRSR----KLIIKPVGLGDTLEILVSAECDCDCQR- 458

  Fly   511 GSIGYQVQANSCS---GHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCS 572
                 :|:|||..   |:|:..||:|.|:..:.|.:||| ..|:.|    ..||: :|.....||
  Rat   459 -----EVEANSSKCHHGNGSFQCGVCACNPGHMGPRCEC-GEDMVS----TDSCK-ESPGHPSCS 512

  Fly   573 GRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSN 637
            |||.|.||.|.||.  :|...|.|.:|:||||||.|::..||.  |:|.|:||.|.|:.||||..
  Rat   513 GRGDCYCGQCVCHL--SPYGSIYGPYCQCDNFSCLRHKGLLCG--DNGDCDCGECVCRDGWTGEY 573

  Fly   638 CGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQ 702
            |.|..|.|.|... .|.:|||.|.|.||.|.|  .:.|. ||..||:||||...|...:.|::|.
  Rat   574 CNCTTSRDACASE-DGVLCSGRGDCVCGKCVC--RNPGA-SGPTCERCPTCGDPCNSRRSCIECY 634

  Fly   703 MYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQM-CKFFDEDDC--KFMFKYSEQGELHVY 764
            :...|:.:  ::|...|.   ..|....|.:.:||..: |....|::|  .|:.....:|:..::
  Rat   635 LSADGQAQ--EECEDKCK---ATGATISEEEFSKDTSVPCSLQGENECLITFLITADNEGKTIIH 694

  Fly   765 AQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENP 829
            ....|:||....:..|::||..||:|:|:.:|.:||||.:.|||:|.|:||.||..|||.||.||
  Rat   695 NISEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNP 759

  Fly   830 IYKQATSTFKNPMY 843
            :|:.:||||||..|
  Rat   760 LYRGSTSTFKNVTY 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	166/477 (35%)
		Integrin_B_tail	692..773	CDD:285239	17/83 (20%)
		Integrin_b_cyt	803..843	CDD:285884	23/39 (59%)
Itgb6	NP_001004263.1	Integrin_beta	30..454	CDD:278776	166/477 (35%)
		Cysteine-rich tandem repeats	456..619		76/182 (42%)
		Integrin_B_tail	624..705	CDD:285239	18/85 (21%)
		Interaction with HAX1. /evidence=ECO:0000250	730..757		16/26 (62%)
		Integrin_b_cyt	732..774	CDD:285884	25/42 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1889
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45713
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830