DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and Itgb2

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001032869.2	Gene:	Itgb2 / 309684	RGDID:	1305581	Length:	768	Species:	Rattus norvegicus

Alignment Length:	833	Identity:	294/833 - (35%)
Similarity:	426/833 - (51%)	Gaps:	108/833 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TAVSTCASKEK---CHTCIQT-EGCAWCMQPDFKGQS-----RCYQNTSSL---CPEEFAYSPIT 87
            :|:|...:|.|   |..|||: .||:||.:.:|.|..     ||......|   ||.:....|.:
  Rat    19 SALSEECTKYKVSNCRDCIQSGPGCSWCQKLNFTGPGEPDSLRCDTRAQLLLKGCPADDIMDPKS 83

  Fly    88 VEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGE 152
            ...      |..||:.:.:
  Rat    84 FAD------LHPQYQVQRS---------------------------------------------- 96

  Fly   153 IVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKR 217
              |:.||.:.|.||..:.....:::.:|:|||:|||||||||.||.||...:..||..|.:.:..
  Rat    97 --QLSPQKVTLNLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNE 159

  Fly   218 ITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCAN----CTATYGFHHQMVLDKNITQFTNEVKNA 278
            ||.:..:||||||||.::|:|:|.|:.|..||.|    |...:.|.|.:.|..|..||..||...
  Rat   160 ITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQ 224

  Fly   279 TVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHL 343
            .:||||||||||.|||||..||..:|||| ...|||||:||.|||:|||||||.::.||||.|||
  Rat   225 LISGNLDAPEGGLDAIMQVAACPEEIGWR-NVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHL 288

  Fly   344 SPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNV 408
            . ...|..|...||||:.|:..|:.::.|..|||||...:..||||.|.|..|:..:|.:|||||
  Rat   289 E-DNMYKRSNEFDYPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSDDSSNV 352

  Fly   409 VELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLSNGPEVQTSK--CDNLKEGQQVSFTAQIQL 470
            |:|:|:.|.|:||.|.:......| :|:||.|.|.:....:..|:  ||.::....|:|..::..
  Rat   353 VQLIKKAYYKLSSRVFLDHTTIPDTLKVTYDSFCNNRVSSIGKSRGDCDGVQINNPVTFQVKVTA 417

  Fly   471 LKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANSCSGHGTSMCGICNC 535
            .:|.::     |:..|..:|..:.:.:|:...|.|.|.:...:     .|.|.|.|...||||.|
  Rat   418 SECIQE-----QSFVIRALGFTDTVTVQVHPQCECQCRDQSRM-----RNLCGGKGVMECGICRC 472

  Fly   536 DDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCE 600
            :..|.|..|||.....:|: ..:.:||.|::|.. |||.|.|:||.|.||....|.::|.|::||
  Rat   473 ESGYIGKNCECQTQGRSSQ-ELEGNCRKDNSSIV-CSGLGDCICGQCVCHTSDIPNKVIFGQYCE 535

  Fly   601 CDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECG 665
            ||||:|||...|:|.|...|:|.||:|.||.|:.||.|.||.|...|:.....| |||.|.|:|.
  Rat   536 CDNFNCERYDGQVCGGLKRGSCSCGQCNCKEGFEGSACQCQRSTTGCLNARLVE-CSGRGRCQCN 599

  Fly   666 VCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGEL-KN-GDDCARNCTQFVPVGVE 728
            .|.|   ::| :....||:||.|...|.....|.:|..:..|.. || ...||....|.||.
  Rat   600 RCIC---EKG-YQPPLCEECPGCPLPCSTYVFCAECLKFDKGPFQKNCSVQCANVTLQTVPF--- 657

  Fly   729 KVEIDETKDEQMCKFFDEDDC--KFMFKYSEQGELHVYAQENKECPAKVFMLGIVMGVIAAIVLV 791
                    .::.||..|.:.|  .:..:..:....:::..:::||.....:..|:.|.:|.:||:
  Rat   658 --------KKKPCKERDSEGCWITYTLQQKDGNAYNIHVDDDRECVKGPNVAAIIGGTVAGVVLI 714

  Fly   792 GLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMYA 844
            |:.:|::||.||.:.|..|:.|||||::.::|: .:||::|.||:|..||.:|
  Rat   715 GVLLLVIWKALTHLTDLNEYRRFEKEKLKSQWN-NDNPLFKSATTTVMNPKFA 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	170/478 (36%)
		Integrin_B_tail	692..773	CDD:285239	17/84 (20%)
		Integrin_b_cyt	803..843	CDD:285884	17/39 (44%)
Itgb2	NP_001032869.2	INB	33..447	CDD:197563	169/474 (36%)
		Integrin_B_tail	622..698	CDD:400356	17/86 (20%)
		Integrin_b_cyt	723..765	CDD:400871	19/42 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1889
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	647	1.000	Inparanoid score	I770
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	1	1.000	-	-		otm45713
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X739
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840