DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and Itgb4

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_038941223.1	Gene:	Itgb4 / 25724	RGDID:	2928	Length:	1872	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	265/822 - (32%)
Similarity:	391/822 - (47%)	Gaps:	132/822 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTE-GCAWCMQPDFKGQSRCYQNTSSL 76
            ||.:.:.|.:.|.. |.:..|       |..:.|..||:.: .||:|....|| :.||  ||
  Rat    13 LLAVVLSAGLPGNM-ANRCKK-------AQVKSCTECIRVDKSCAYCTDELFK-ERRC--NT--- 63

  Fly    77 CPEEFAYSPITVEQILVNNKLTNQYKAELAAGG--GGSAMSGSSSSSYSSSSSSSSFYSQSSSGS 139
                                     :|||.|.|  |.|.:...||...:.:....:...:|
  Rat    64 -------------------------QAELLAAGCRGESVLVMESSLEITENIQIDTSLHRS---- 99

  Fly   140 SSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKL 204
                           |:.||.:::.||..|:.|......:....|||||.|||.|.||.||...|
  Rat   100 ---------------QVSPQGLQVRLRPGEERNFVFKVFEPLESPVDLYILMDFSNSMSDDLDNL 149

  Fly   205 STLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCANCTATYGFHHQMVLDKNIT 269
            ..:|..|::.::::|:::.:|||.|||||.:|.....|:.|.||..|....:.|.:.:.|.:|:.
  Rat   150 KQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVE 214

  Fly   270 QFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGK--LGG 332
            :|.::::...:||||||||||||||:|...|...||||..:..||||||::.|||..||.  |.|
  Rat   215 EFWDKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAG 279

  Fly   333 VIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSS 397
            ::..||.:|||...|.||....|||||:..:.:.:..:.|..|||||....|.||||.::...||
  Rat   280 IMNRNDEKCHLDATGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSS 344

  Fly   398 AAKLDNDSSNVVELVKEEYRKISSSVEMK--DNATGDVKITYFSSCLSNGPEVQTSKCDNLKEGQ 460
            ...|..||||:|||::|.:.:|.|:::::  |:..| ::....|..|.   :.:|... ::|.|:
  Rat   345 LGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRG-LRTEVTSDTLQ---KTETGSF-HIKRGE 404

  Fly   461 QVSFTAQIQLLK-------CPEDPRDWTQTIHISPVGINEVMQIQLTMLCS-CPCENPGSIGYQV 517
            ..::...::.::       |.....|....||:.| ..::.:::..:::|. |.||    :..:|
  Rat   405 VGTYNVHLRAVEDIDGTHVCQMAKEDQRGNIHLKP-SFSDGLRMDASVICDVCACE----LQKEV 464

  Fly   518 QANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGAC 582
            |:..|...|..|||.|.|::.:.|..|.||...|     :||...........|||.|.|.||.|
  Rat   465 QSARCHYRGDFMCGHCVCNEGWSGKTCNCSTGSL-----SDTQPCLREGEDKPCSGHGECQCGRC 524

  Fly   583 ECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTC 647
            .|:....    ..|..||.|||.|.|....||:  |.|.|..|.|.|:|||||.:|.|..||.||
  Rat   525 VCYGEGR----YEGHFCEYDNFQCPRTSGFLCN--DRGRCSMGECVCEPGWTGRSCDCPLSNATC 583

  Fly   648 MPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCS--------GRCQELKDCVQCQMY 704
            :...|| ||:|.|.||||.|.|     .:.|..:.:  .||.        |.|::|:.|||||.:
  Rat   584 IDSNGG-ICNGLGFCECGRCHC-----NQRSSLYTD--TTCEINYSAIRLGLCEDLRSCVQCQAW 640

  Fly   705 KTGELKNGDDCARNCTQFVPVGVEKVEIDETKDE----QMCKFFDE-DDCKFMFKYSEQGE---- 760
            .||| |.|..| ..|...|.:      :||.|..    :.|.|.|| |||  .:.|:.:|:
  Rat   641 GTGE-KKGRTC-EECNFKVKM------VDELKKAEEVVEYCSFRDEDDDC--TYSYTVEGDGSPG 695

  Fly   761 --LHVYAQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWK 800
              ..|...:.|:||...|...|.:.:...::|| |.:||.||
  Rat   696 PNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLV-LLLLLCWK 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	147/474 (31%)
		Integrin_B_tail	692..773	CDD:285239	30/91 (33%)
		Integrin_b_cyt	803..843	CDD:285884
Itgb4	XP_038941223.1	vWFA	37..454	CDD:412136	146/472 (31%)
		I-EGF_1	458..486	CDD:408172	11/31 (35%)
		Integrin_B_tail	628..711	CDD:400356	31/92 (34%)
		Calx_beta	992..1086	CDD:197594
		fn3	1130..1210	CDD:394996
		FN3	1222..1315	CDD:238020
		FN3	1577..1658	CDD:238020
		fn3	1691..1776	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020