DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and Itgb1

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_006255886.1	Gene:	Itgb1 / 24511	RGDID:	2927	Length:	801	Species:	Rattus norvegicus

Alignment Length:	859	Identity:	359/859 - (41%)
Similarity:	473/859 - (55%)	Gaps:	98/859 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 MIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWC-----MQPDFKGQSRCYQNT 73
            :|:::.::.||||..:..|       |:.:.|..|||. ..|.||     :|......:|| .:.
  Rat    11 LISLICSVFGQTDKNRCLK-------ANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARC-DDL 67

  Fly    74 SSL----CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQ 134
            .:|    |......:|...:.|..|..:||:.|        |.|
  Rat    68 EALKKKGCQPSDIENPRGSQTIKKNKNVTNRSK--------GMA--------------------- 103

  Fly   135 SSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMED 199
                       |:....:|.|||||.:.|.||..|.....:.:.:||.||:|||||||||.||:|
  Rat   104 -----------EKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKD 157

  Fly   200 DKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCA---NCTATYGFHHQ 261
            |...:.:||..|...|:|||::|.:||||||:|.:|||:||.|..|..||.   |||:.:.:.:.
  Rat   158 DLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNV 222

  Fly   262 MVL-DKNITQFTNE-VKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHY 324
            :.| |:.  :|.|| |....:|||||:||||||||||...|.|.|||| ...||||||||||||:
  Rat   223 LSLTDRG--EFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWR-NVTRLLVFSTDAGFHF 284

  Fly   325 AGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKL 389
            ||||||||::.||||:|||. ...||.|...|||||:.:.||:.:|.|..|||||.....||::|
  Rat   285 AGDGKLGGIVLPNDGQCHLE-NNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKEL 348

  Fly   390 VEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLS--NGPEVQTS 451
            ...|..|:...|..:||||::|:.:.|..:||.|.::::...| |.|.|.|.|.:  ||......
  Rat   349 KNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGR 413

  Fly   452 KCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQ 516
            ||.|:..|.:|.|...|...|||...   ::||.|.|:|..|.:::.|..:|.|.|:   |.|..
  Rat   414 KCSNISIGDEVQFEISITANKCPNKE---SETIKIKPLGFTEEVEVVLQFICKCNCQ---SHGIP 472

  Fly   517 VQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGA 581
            .......|:||..||.|.|::...|..||||..::.|: ..|..||.:::|.. ||..|.||||.
  Rat   473 ASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSE-DMDAYCRKENSSEI-CSNNGECVCGQ 535

  Fly   582 CECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDT 646
            |.|.||.|..||.|||.||||||:|:|:...:|.|  :|.|.|..|:|.|.:|||.|.|......
  Rat   536 CVCRKRENTNEIYSGKFCECDNFNCDRSNGLICGG--NGVCRCRVCECYPNYTGSACDCSLDTVP 598

  Fly   647 CMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKN 711
            |:.. .|:||:|.|.||||.||||   ..:|.|..||.|.||.|.|.|.|:||||:.:..||.|
  Rat   599 CVAT-NGQICNGRGICECGACKCT---DPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKK- 658

  Fly   712 GDDCARNCTQFVPVGVEKVEIDETKDEQM-------CKFFDEDDCKFMFKYS--EQGELHVYAQE 767
             |.||:.|:.|   .:.|||..|...:.:       ||..|.|||.|.|.||  ..||.||:..|
  Rat   659 -DTCAQECSHF---NLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNSNGEAHVHVVE 719

  Fly   768 NKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYK 832
            ..:||....::.||.||:|.|||:|||:||:||||..||||||||:||||:|||||||.||||||
  Rat   720 TPDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTQENPIYK 784

  Fly   833 QATSTFKNPMYAGK 846
            ...:.||||.|..|
  Rat   785 SPINNFKNPNYGRK 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	187/477 (39%)
		Integrin_B_tail	692..773	CDD:285239	35/89 (39%)
		Integrin_b_cyt	803..843	CDD:285884	29/39 (74%)
Itgb1	XP_006255886.1	Integrin_beta	34..464	CDD:278776	187/477 (39%)
		Integrin_B_tail	640..727	CDD:285239	36/91 (40%)
		Integrin_b_cyt	757..796	CDD:285884	29/38 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1889
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22999
Inparanoid	1	1.050	647	1.000	Inparanoid score	I770
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	1	1.000	-	-		otm45713
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	LDO	PTHR10082
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X739
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840