Protein Alignment mys and Itgb4

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_017169838.1
• Gene: Itgb4 / 192897
• MGIID: 96613
• Length: 1871
• Species: Mus musculus
• Alignment Length: 816
• Identity: 270/816 - (33%)
• Similarity: 394/816 - (48%)
• Gaps: 120/816 - (14%)

  Fly    13 LLMIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQTE-GCAWCMQPDFKGQSRCYQNTSSL 76
            ||:.|:|:|......|.:..|       |..:.|..||:.: .||:|....|| :.||  ||
Mouse    13 LLLAAMLSASLPGDLANRCKK-------AQVKSCTECIRVDKSCAYCTDELFK-ERRC--NT--- 64

  Fly    77 CPEEFAYSPITVEQILVNNKLTNQYKAELAAGG--GGSAMSGSSSSSYSSSSSSSSFYSQSSSGS 139
                                     :|||.|.|  |.|.:...||...:.::...:...:|
Mouse    65 -------------------------QAELLAAGCRGESILVMESSLEITENTQIDTSLHRS---- 100

  Fly   140 SSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKL 204
                           |:.||.:::.||..|:.:......:....|||||.|||.|.||.||...|
Mouse   101 ---------------QVSPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNL 150

  Fly   205 STLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCENCKAPYGYQNHMPLNNNTE 269
            ..:|..|::.::::|:::.:|||.|||||.:|.....|:||:.|..|...|:.::|.:.|..|.|
Mouse   151 KQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVE 215

  Fly   270 SFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGK--LGG 332
            .|.|:::...:||||||||||||||:|...|...||||..:..||||||::.|||..||.  |.|
Mouse   216 EFWNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAG 280

  Fly   333 VIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSS 397
            ::..||.:|||...|.||....|||||:..:.:.:..:.|..|||||....|.||||.::...||
Mouse   281 IMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSS 345

  Fly   398 AAKLDNDSSNVVELVKEEYRKISSSVEMK--DNATGDVKITYFSSCLSNGPEVQTSKCDNLKEGQ 460
            ...|..||||:|||::|.:.:|.|:::::  |:..| ::....|..|.   :.:|... ::|.|:
Mouse   346 LGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRG-LRTEVTSDTLQ---KTETGSF-HIKRGE 405

  Fly   461 QVSFTAQIQLLK-------CPEDPRDWTQTIHISPVGINEVMQIQLTMLCS-CPCENPGSIGYQV 517
            ..::...::.::       |.....|....||:.| ..::.:::..:::|. ||||    :..:|
Mouse   406 VGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKP-SFSDGLRMDASVICDVCPCE----LQKEV 465

  Fly   518 QANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGAC 582
            ::..|...|..|||.|.|::.:.|..|.||...|     :||...........|||.|.|.||.|
Mouse   466 RSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSL-----SDTQPCLREGEDKPCSGHGECQCGRC 525

  Fly   583 ECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTC 647
            .|:....    ..|..||.|||.|.|....||:  |.|.|..|.|.|:|||||.:|.|..||.||
Mouse   526 VCYGEGR----YEGHFCEYDNFQCPRTSGFLCN--DRGRCSMGECVCEPGWTGRSCDCPLSNATC 584

  Fly   648 MPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCE--KCPTCSGRCQELKDCVQCQMYKTGELK 710
            :...|| ||:|.|.||||.|.|  |.|..::...||  ......|.|::|:.|||||.:.|||.|
Mouse   585 IDSNGG-ICNGRGYCECGRCHC--NQQSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKK 646

  Fly   711 NG--DDCARNCTQFVPVGVEKVEIDETKDE----QMCKFFDE-DDCKFMFKYSEQG----ELHVY 764
            ..  |||        |..|:.|  ||.|..    :.|.|.|| |||.:.:.....|    ...|.
Mouse   647 GRACDDC--------PFKVKMV--DELKKAEEVVEYCSFRDEDDDCTYSYNVEGDGSPGPNSTVL 701

  Fly   765 AQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWK 800
            ..:.|:||...|...|.: :|..::|:.|.:||.||
Mouse   702 VHKKKDCPPGSFWWLIPL-LIFLLLLLALLLLLCWK 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	149/474 (31%)
		Integrin_B_tail	692..775	CDD:462325	32/93 (34%)
		Integrin_b_cyt	803..843	CDD:462580
Itgb4	XP_017169838.1	vWFA	38..455	CDD:469594	148/472 (31%)
		I-EGF_1	459..487	CDD:465729	10/31 (32%)
		Integrin_B_tail	628..711	CDD:462325	32/92 (35%)
		Calx_beta	992..1086	CDD:197594
		fn3	1130..1210	CDD:394996
		FN3	1222..1315	CDD:238020
		FN3	1577..1658	CDD:238020
		fn3	1691..1776	CDD:394996