DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mys and Itgb6

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001153036.1	Gene:	Itgb6 / 16420	MGIID:	96615	Length:	787	Species:	Mus musculus

Alignment Length:	859	Identity:	303/859 - (35%)
Similarity:	456/859 - (53%)	Gaps:	112/859 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLMIAILAAIAGQTDAQKAAKLTAVSTCA--SKEKCHTCIQT-EGCAWCMQPDFKGQS----R 68
            :.:.::.:...:.|:.|..:..       ||  ..|.|..|:.| ..||||.|.:|...|    |
Mouse     1 MGIELVCLFLLLLGRNDHVQGG-------CAWGGAESCSDCLLTGPHCAWCSQENFTHLSGAGER 58

  Fly    69 CYQNTSSL---CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSS 130
            |....:.|   |...|..:|::..::|.|..|                       |.....:||
Mouse    59 CDTPANLLAKGCQLPFIENPVSRIEVLQNKPL-----------------------SVGRQKNSS- 99

  Fly   131 FYSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSK 195
                                 :||||.|||:.|.||...:..:::...|.|.||||||||||||.
Mouse   100 ---------------------DIVQIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSA 143

  Fly   196 SMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCAN----CTATY 256
            ||:||...:..||.:|::.|.::|:||.|||||||:|.:.|::.|.|:.:..||::    |..|:
Mouse   144 SMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTF 208

  Fly   257 GFHHQMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAG 321
            ||.|.:.|..:..:|...|:...:|.|:|.|||||||||||..|:.:||||..:..||||.:||.
Mouse   209 GFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDAD 273

  Fly   322 FHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVY 386
            .|:..|.||.|::.||||.|||..:.||:.||:.:||:|.|:..|:..|.:.:|||||..|:.:|
Mouse   274 SHFGMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLY 338

  Fly   387 EKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD---VKITYFSSCLSNG--- 445
            |...:.|.|::...|..||.|:::|:...|.::.|.||::  ..||   :.:::.:.| :||
Mouse   339 ENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELE--VLGDTEGLNLSFTALC-NNGVLF 400

  Fly   446 PEVQTSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENP 510
            |  ...||.::|.|...||...:.:..|.:..|:    :.|.|||:.:.::|.::..|.|.|:.
Mouse   401 P--HQKKCSHMKVGDTASFNVTVSVSNCEKRSRN----LIIKPVGLGDTLEILVSAECDCDCQR- 458

  Fly   511 GSIGYQVQANS--C-SGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCS 572
                 :::.||  | :|:|:..||:|.|:..:.|..||| ..|:.|    ..||: :|.....||
Mouse   459 -----EIETNSSKCHNGNGSFQCGVCTCNPGHMGPHCEC-GEDMVS----TDSCK-ESPGHPSCS 512

  Fly   573 GRGHCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSN 637
            |||.|.||.|.||.  :|...|.|.:|:||||||.|::..||.  |:|.|:||.|.|:.||||..
Mouse   513 GRGDCYCGQCICHL--SPYGSIYGPYCQCDNFSCLRHKGLLCG--DNGDCDCGECVCRDGWTGEY 573

  Fly   638 CGCQESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQ 702
            |.|..:.|:|... .|.:|||.|.|.||.|.|  .:.|. ||..||:||||...|...:.|::|.
Mouse   574 CNCTTNRDSCTSE-DGVLCSGRGDCVCGKCVC--RNPGA-SGPTCERCPTCGDPCNSKRSCIECY 634

  Fly   703 MYKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQM-CKFFDEDDC--KFMFKYSEQGELHVY 764
            :...|:.:  ::||..|.   .:|....|.|.:||..: |....|::|  .|:.....:|:..::
Mouse   635 LSADGQAQ--EECADKCK---AIGATISEEDFSKDTSVSCSLQGENECLITFLITTDNEGKTIIH 694

  Fly   765 AQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENP 829
            ....|:||....:..|::||..||:|:|:.:|.:||||.:.|||:|.|:||.||..|||.||.||
Mouse   695 NINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNP 759

  Fly   830 IYKQATSTFKNPMY 843
            :|:.:||||||..|
Mouse   760 LYRGSTSTFKNVTY 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	164/477 (34%)
		Integrin_B_tail	692..773	CDD:285239	19/83 (23%)
		Integrin_b_cyt	803..843	CDD:285884	23/39 (59%)
Itgb6	NP_001153036.1	INB	30..454	CDD:197563	164/477 (34%)
		Cysteine-rich tandem repeats	456..619		74/182 (41%)
		I-EGF_1	456..485	CDD:408172	10/34 (29%)
		exchanger_TraA	<467..>646	CDD:411343	78/194 (40%)
		Integrin_B_tail	624..705	CDD:400356	20/85 (24%)
		Integrin_b_cyt	730..773	CDD:400871	26/42 (62%)
		Interaction with HAX1. /evidence=ECO:0000250	730..757		16/26 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	261	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48224
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43636
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820