DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and Itgb2l

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_006522991.1	Gene:	Itgb2l / 16415	MGIID:	1277979	Length:	795	Species:	Mus musculus

Alignment Length:	795	Identity:	240/795 - (30%)
Similarity:	361/795 - (45%)	Gaps:	135/795 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWCMQPDFKGQSRCYQNTSSLCPEEF 81
            :|..:||....:.|  |:.:.|..:...|..||:: ..||||.:.:|.|:.   :..|..|.
Mouse     7 LLPVLAGLLSLESA--LSQLCTKDNVSTCQDCIRSGPSCAWCQKLNFTGRG---EPDSVRCD--- 63

  Fly    82 AYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYE 146
                 |.||:|:.. .|::|..:                                  ..|.:..:
Mouse    64 -----TPEQLLLKG-CTSEYLVD----------------------------------PKSLAESQ 88

  Fly   147 EYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKL 211
            |....:..|:.|:::.:.||..:....|:.:.:.:...||||:||.||.|.:...:.:.|||..|
Mouse    89 EDKERDQRQLSPRNVTVFLRPGQAATFKVDFQRTQDNSVDLYFLMGLSGSAQGHLSNVQTLGSDL 153

  Fly   212 SETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCANCTATYGFHHQMVLDKNITQFTNEVK 276
            .:.:..|:.:..:||||.|                    |.|    |.|.:.|..:.:||..|::
Mouse   154 LKALNEISRSGRIGFGSIV--------------------NMT----FQHILKLTADSSQFQRELR 194

  Fly   277 NATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGEC 341
            ...|||.|..|:|..||::|...|..:|||| ...|.||..||..||.|.|..||.....:||.|
Mouse   195 KQLVSGKLATPKGQLDAVVQVAICLGEIGWR-NGTRFLVLVTDNDFHLAKDKTLGTRQNTSDGRC 258

  Fly   342 HLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSS 406
            ||. .|.|......||.|:.|:..|:.:|.|..||.|.:..:..||||...|...:..:|.:|||
Mouse   259 HLD-DGMYRSRGEPDYQSVVQLASKLAENNIQPIFVVPSRMVKTYEKLTTFIPKLTIGELSDDSS 322

  Fly   407 NVVELVKEEYRKISSSVEMKDNATGDV-KITYFSSCLSNG---PEVQTSKCDNLKEGQQVSFTAQ 467
            ||.:|::..|.|:||.|.:..:....: |:||.|.| |||   |...:..|..::...||:|...
Mouse   323 NVAQLIRNAYSKLSSIVVLNHSTIPSILKVTYDSYC-SNGTSNPGKPSGDCSGVQINDQVTFQVN 386

  Fly   468 IQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANS-CSGHGTSMCG 531
            |...:|..:     |...|..:|..:.:.:::..||.|.|:.      |.|.:| |.|.|...||
Mouse   387 ITASECFRE-----QFFFIQALGFMDSVTVRVLPLCECQCQE------QSQHHSLCGGKGAMECG 440

  Fly   532 ICNCDDSYFGNKCEC-----SATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPI 591
            ||.|:..|.|..|||     |:.||      :.|||.|::|.. |||.|.|:||.||||....|.
Mouse   441 ICRCNSGYAGKNCECQTQGPSSQDL------EGSCRKDNSSIM-CSGLGDCICGQCECHTSDIPN 498

  Fly   592 EIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEIC 656
            :.|.|::|||:|.:|||...|:|.||:.|.|.||||.|:.|:.||.|.|:.|...|:.....| |
Mouse   499 KEIYGQYCECNNVNCERYDGQVCGGPERGHCSCGRCFCRYGFVGSACQCRMSTSGCLNNRMVE-C 562

  Fly   657 SGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGDDCARNCTQ 721
            ||||.|.|..|.|   |.| :....|||.|....||.|...|.:|       ||  |:.|..|.:
Mouse   563 SGHGRCYCNRCLC---DPG-YQPPLCEKRPGYFHRCSEYYSCARC-------LK--DNSAIKCRE 614

  Fly   722 -----FVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGELH-VYAQENKECPAKV----F 776
                 |.............:|.:.|.      ..:.....:|.::: :|.:|:..| |::    .
Mouse   615 CWNLLFSNTPFSNKTCMTERDSEGCW------TTYTLYQPDQSDINSIYIKESLVC-AEISNTTI 672

  Fly   777 MLGIVMGVIAAIVLV 791
            :||:::||:.|::.:
Mouse   673 LLGVIVGVLLAVIFL 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	130/464 (28%)
		Integrin_B_tail	692..773	CDD:285239	16/86 (19%)
		Integrin_b_cyt	803..843	CDD:285884
Itgb2l	XP_006522991.1	vWFA	32..419	CDD:381780	130/464 (28%)
		I-EGF_1	417..448	CDD:375798	14/36 (39%)
		Integrin_B_tail	594..666	CDD:369622	16/87 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6356
eggNOG	1	0.900	-	-		E1_KOG1226
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100678
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X739
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790