Protein Alignment mys and Itgb1

DIOPT Version :10

• Sequence 1: NP_524793.2
• Gene: mys / 44885
• FlyBaseID: FBgn0004657
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_034708.1
• Gene: Itgb1 / 16412
• MGIID: 96610
• Length: 798
• Species: Mus musculus
• Alignment Length: 857
• Identity: 361/857 - (42%)
• Similarity: 476/857 - (55%)
• Gaps: 94/857 - (10%)

  Fly    15 MIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWC-----MQPDFKGQSRCYQNT 73
            :|:::.::.||||..:..|       |:.:.|..|||. ..|.||     :|......:|| .:.
Mouse    11 LISLICSVFGQTDKNRCLK-------ANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARC-DDL 67

  Fly    74 SSL----CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQ 134
            .:|    |......:|...:.|..|..:||:.|        |.|
Mouse    68 EALKKKGCQPSDIENPRGSQTIKKNKNVTNRSK--------GMA--------------------- 103

  Fly   135 SSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMED 199
                       |:....:|.|||||.:.|.||..|.....:.:.:||.||:|||||||||.||:|
Mouse   104 -----------EKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKD 157

  Fly   200 DKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPC---ENCKAPYGYQNH 261
            |...:.:||..|...|:|||::|.:||||||:|.:|||:||.|.||.:||   :||.:|:.|:|.
Mouse   158 DLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNV 222

  Fly   262 MPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAG 326
            :.|.:..|.|:..|....:|||||:||||||||||...|.|.|||| ...||||||||||||:||
Mouse   223 LSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWR-NVTRLLVFSTDAGFHFAG 286

  Fly   327 DGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVE 391
            ||||||::.||||:|||. ...||.|...|||||:.:.||:.:|.|..|||||.....||::|..
Mouse   287 DGKLGGIVLPNDGQCHLE-NNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKN 350

  Fly   392 HIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLS--NGPEVQTSKC 453
            .|..|:...|..:||||::|:.:.|..:||.|.::::...| |.|.|.|.|.:  ||......||
Mouse   351 LIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGRKC 415

  Fly   454 DNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQ 518
            .|:..|.:|.|...|...|||...   ::||.|.|:|..|.:::.|..:|.|.|:   |.|....
Mouse   416 SNISIGDEVQFEISITANKCPNKE---SETIKIKPLGFTEEVEVVLQFICKCNCQ---SHGIPAS 474

  Fly   519 ANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACE 583
            .....|:||..||.|.|::...|..||||..::.|: ..|..||.:::|.. ||..|.||||.|.
Mouse   475 PKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSE-DMDAYCRKENSSEI-CSNNGECVCGQCV 537

  Fly   584 CHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCM 648
            |.||.|..||.|||.||||||:|:|:...:|.|  :|.|.|..|:|.|.:|||.|.|......|:
Mouse   538 CRKRDNTNEIYSGKFCECDNFNCDRSNGLICGG--NGVCRCRVCECYPNYTGSACDCSLDTGPCL 600

  Fly   649 PPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGD 713
             ...|:||:|.|.||||.||||   ..:|.|..||.|.||.|.|.|.|:||||:.:..||.|  |
Mouse   601 -ASNGQICNGRGICECGACKCT---DPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKK--D 659

  Fly   714 DCARNCTQFVPVGVEKVEIDETKDEQM-------CKFFDEDDCKFMFKYSEQG--ELHVYAQENK 769
            .||:.|:.|   .:.|||..|...:.:       ||..|.|||.|.|.||..|  |..|:..|..
Mouse   660 TCAQECSHF---NLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNGNNEAIVHVVETP 721

  Fly   770 ECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQA 834
            :||....::.||.||:|.|||:|||:||:||||..||||||||:||||:||||||||||||||.|
Mouse   722 DCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSA 786

  Fly   835 TSTFKNPMYAGK 846
            .:|..||.|.||
Mouse   787 VTTVVNPKYEGK 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_524793.2	INB	45..505	CDD:197563	188/475 (40%)
		Integrin_B_tail	692..775	CDD:462325	35/91 (38%)
		Integrin_b_cyt	803..843	CDD:462580	30/39 (77%)
Itgb1	NP_034708.1	INB	34..464	CDD:197563	188/475 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..104		8/67 (12%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05556	207..213		1/5 (20%)
		CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05556	295..314		10/19 (53%)
		Interaction with TMEM182. /evidence=ECO:0000250|UniProtKB:P07228	383..465		26/84 (31%)
		I-EGF_1	466..495	CDD:465729	10/31 (32%)
		Integrin_B_tail	640..727	CDD:462325	35/91 (38%)
		Integrin_b_cyt	755..795	CDD:462580	30/39 (77%)
		Signal for sorting from recycling endosomes, interaction with ACAP1. /evidence=ECO:0000250	762..767		3/4 (75%)
		Interaction with ITGB1BP1. /evidence=ECO:0000250	785..792		2/6 (33%)