DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mys and Itgb1

DIOPT Version :9

Sequence 1:NP_001284997.1 Gene:mys / 44885 FlyBaseID:FBgn0004657 Length:846 Species:Drosophila melanogaster
Sequence 2:NP_034708.1 Gene:Itgb1 / 16412 MGIID:96610 Length:798 Species:Mus musculus


Alignment Length:859 Identity:360/859 - (41%)
Similarity:473/859 - (55%) Gaps:98/859 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 MIAILAAIAGQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWC-----MQPDFKGQSRCYQNT 73
            :|:::.::.||||..:..|       |:.:.|..|||. ..|.||     :|......:|| .:.
Mouse    11 LISLICSVFGQTDKNRCLK-------ANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARC-DDL 67

  Fly    74 SSL----CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQ 134
            .:|    |......:|...:.|..|..:||:.|        |.|                     
Mouse    68 EALKKKGCQPSDIENPRGSQTIKKNKNVTNRSK--------GMA--------------------- 103

  Fly   135 SSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMED 199
                       |:....:|.|||||.:.|.||..|.....:.:.:||.||:|||||||||.||:|
Mouse   104 -----------EKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKD 157

  Fly   200 DKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCA---NCTATYGFHHQ 261
            |...:.:||..|...|:|||::|.:||||||:|.:|||:||.|..|..||.   |||:.:.:.:.
Mouse   158 DLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNV 222

  Fly   262 MVL-DKNITQFTNE-VKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHY 324
            :.| |:.  :|.|| |....:|||||:||||||||||...|.|.|||| ...||||||||||||:
Mouse   223 LSLTDRG--EFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWR-NVTRLLVFSTDAGFHF 284

  Fly   325 AGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKL 389
            ||||||||::.||||:|||. ...||.|...|||||:.:.||:.:|.|..|||||.....||::|
Mouse   285 AGDGKLGGIVLPNDGQCHLE-NNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKEL 348

  Fly   390 VEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD-VKITYFSSCLS--NGPEVQTS 451
            ...|..|:...|..:||||::|:.:.|..:||.|.::::...| |.|.|.|.|.:  ||......
Mouse   349 KNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGR 413

  Fly   452 KCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQ 516
            ||.|:..|.:|.|...|...|||...   ::||.|.|:|..|.:::.|..:|.|.|:   |.|..
Mouse   414 KCSNISIGDEVQFEISITANKCPNKE---SETIKIKPLGFTEEVEVVLQFICKCNCQ---SHGIP 472

  Fly   517 VQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGA 581
            .......|:||..||.|.|::...|..||||..::.|: ..|..||.:::|.. ||..|.||||.
Mouse   473 ASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSE-DMDAYCRKENSSEI-CSNNGECVCGQ 535

  Fly   582 CECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDT 646
            |.|.||.|..||.|||.||||||:|:|:...:|.|  :|.|.|..|:|.|.:|||.|.|......
Mouse   536 CVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGG--NGVCRCRVCECYPNYTGSACDCSLDTGP 598

  Fly   647 CMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKN 711
            |: ...|:||:|.|.||||.||||   ..:|.|..||.|.||.|.|.|.|:||||:.:..||.| 
Mouse   599 CL-ASNGQICNGRGICECGACKCT---DPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKK- 658

  Fly   712 GDDCARNCTQFVPVGVEK-------VEIDETKDEQMCKFFDEDDCKFMFKYSEQG--ELHVYAQE 767
             |.||:.|:.|....||.       |::|....   ||..|.|||.|.|.||..|  |..|:..|
Mouse   659 -DTCAQECSHFNLTKVESREKLPQPVQVDPVTH---CKEKDIDDCWFYFTYSVNGNNEAIVHVVE 719

  Fly   768 NKECPAKVFMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYK 832
            ..:||....::.||.||:|.|||:|||:||:||||..||||||||:||||:||||||||||||||
Mouse   720 TPDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYK 784

  Fly   833 QATSTFKNPMYAGK 846
            .|.:|..||.|.||
Mouse   785 SAVTTVVNPKYEGK 798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mysNP_001284997.1 INB 45..505 CDD:197563 187/477 (39%)
Integrin_B_tail 692..773 CDD:285239 34/89 (38%)
Integrin_b_cyt 803..843 CDD:285884 30/39 (77%)
Itgb1NP_034708.1 INB 34..464 CDD:197563 187/477 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..104 8/67 (12%)
CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05556 207..213 1/5 (20%)
CX3CL1-binding. /evidence=ECO:0000250|UniProtKB:P05556 295..314 10/19 (53%)
Cysteine-rich tandem repeats 466..635 77/179 (43%)
I-EGF_1 466..495 CDD:375798 10/31 (32%)
EGF_2 602..630 CDD:285248 15/30 (50%)
Integrin_B_tail 640..727 CDD:369622 35/91 (38%)
Integrin_b_cyt 757..795 CDD:370082 30/37 (81%)
Signal for sorting from recycling endosomes, interaction with ACAP1. /evidence=ECO:0000250 762..767 3/4 (75%)
Interaction with ITGB1BP1. /evidence=ECO:0000250 785..792 2/6 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 261 1.000 Domainoid score I1946
eggNOG 1 0.900 - - E1_KOG1226
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H22999
Inparanoid 1 1.050 647 1.000 Inparanoid score I792
Isobase 1 0.950 - 0 Normalized mean entropy S3795
OMA 1 1.010 - - QHG48224
OrthoDB 1 1.010 - - D223415at33208
OrthoFinder 1 1.000 - - FOG0001086
OrthoInspector 1 1.000 - - otm43636
orthoMCL 1 0.900 - - OOG6_100678
Panther 1 1.100 - - LDO PTHR10082
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2712
SonicParanoid 1 1.000 - - X739
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.820

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