DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and itgb2

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_031749002.1	Gene:	itgb2 / 100492659	XenbaseID:	XB-GENE-988513	Length:	826	Species:	Xenopus tropicalis

Alignment Length:	839	Identity:	299/839 - (35%)
Similarity:	438/839 - (52%)	Gaps:	113/839 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LTAVSTCASKEK---CHTCIQT-EGCAWCMQPDFKGQSRCYQNTSSLCPEEFAYSPITVEQILVN 94
            :||.|...:|.|   |:.|||: ..||||.||:|         ||:..|:...   ...:::|
Frog    75 VTATSKVCTKFKVSNCNECIQSGPFCAWCKQPNF---------TSAGEPDSVR---CDTDEVL-- 125

  Fly    95 NKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASGYEEYSAGEIVQIQPQ 159
                            |..........|..|.|.....::.|               :.||:.|:
Frog   126 ----------------GKRGCKEVDIVYHDSRSVVKDRTRLS---------------DRVQLTPR 159

  Fly   160 SMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHL 224
            .:.|.||..:.....:::.:|:|||||||||||||.||.||...:..||..|.|.:.:||.:..:
Frog   160 EISLQLRPGKAAEFDVTFRRAQGYPVDLYYLMDLSYSMNDDLQNVKNLGSNLLEALNKITTSAQI 224

  Fly   225 GFGSFVDKVLMPYVSTIPKNLVEPC----ANCTATYGFHHQMVLDKNITQFTNEVKNATVSGNLD 285
            ||||||||.::|:|:|.|:.|..||    .||...:.|.|.:.|.::..||.::|....:|||||
Frog   225 GFGSFVDKTVLPFVNTHPEKLKNPCPERNENCQPPFAFKHILKLTEDGKQFQDQVGKQGISGNLD 289

  Fly   286 APEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYT 350
            |||||.||:||...|..:|||| ...||||::||.|||.||||||..::.||||:|||. ...|.
Frog   290 APEGGLDAMMQVAVCGDKIGWR-NVTRLLVYATDDGFHIAGDGKLASILIPNDGQCHLE-DNLYK 352

  Fly   351 HSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEE 415
            .|...||||:.|:.||:.:|.|..:||||::.:..|..|.:.|..|...:|.:||.|||:|:.:.
Frog   353 RSNEFDYPSVGQLAQKLSENNIQAVFAVTSNMVQTYRNLSKLIPKSVVGELSSDSRNVVQLITDA 417

  Fly   416 YRKISSSVEMKDNATGD-VKITYFSSCLSNGPEVQ-TSKCDNLKEGQQVSFTAQIQLLKCPEDPR 478
            |:.:||.|.:....|.| ::|.|.|.|..:..|.| ...|.|:|.|:::.|..::...||.:|
Frog   418 YQALSSEVILDHGTTPDFLEILYDSLCPGDIKENQLKGMCSNVKIGEEIKFKVKVTASKCLQD-- 480

  Fly   479 DWTQTIHISPVGINEVMQIQLTMLCSCPCE---NPGSIGYQVQANSCSGHGTSMCGICNCDDSYF 540
               |:..|.|:|..:.:.:.:..||.|.|:   .||         .|:.:||..||||:|::.:.
Frog   481 ---QSFAIRPLGFTDTLTVSVRTLCDCECDETPRPG---------DCNSNGTIKCGICSCNEGFV 533

  Fly   541 GNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPNPIEIISGKHCECDNFS 605
            |..|||.....||: ..:.||:.::.|.. |||.|.|:||.|.||...:..:.|.|::|:|||::
Frog   534 GKNCECVTGGKTSQ-ELEQSCKKENGSAV-CSGAGDCICGQCTCHTNEDTSKKIYGQYCQCDNWN 596

  Fly   606 CERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQESNDTCMPPGGGEICSGHGTCECGVCKCT 670
            ||....:||:|  .|||:||.|:|..|:.||.|.|:.|...| ....|.:|||.|.|||..|.|
Frog   597 CELFEGRLCAG--QGTCDCGVCRCNEGYEGSACQCKRSTSNC-KNAKGSVCSGRGKCECNNCIC- 657

  Fly   671 VNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGDDCARNCTQFVPVGVEKVEIDET 735
               :..:...|||.||.|...|.:...||:|.      :...|...:||:...| ||:...::|.
Frog   658 ---KPGYLQPHCESCPGCPSPCSKFGPCVECY------INQEDGSTQNCSHLCP-GVKAERVEEL 712

  Fly   736 KDEQMCKFFDEDDC-------------KFMFKYSEQGELHVYAQENKECPAKVFMLGIVMGVIAA 787
            |.|.:||..|..:|             ||...|:.:          :|||.....:.||.|..|.
Frog   713 KRETVCKEKDSSNCWMQYVIVEDDGEDKFTITYTLK----------RECPEAPNFVAIVGGTTAG 767

  Fly   788 IVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMYAGK 846
            ::|:|:|.|::||::|.|.||.|:.||||||.|.||:...||:|.:||:|.:||.::|:
Frog   768 VILIGMACLIIWKIITEIKDRNEYNRFEKERQNCKWNQASNPLYHKATTTVQNPNFSGE 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	167/469 (36%)
		Integrin_B_tail	692..773	CDD:285239	22/93 (24%)
		Integrin_b_cyt	803..843	CDD:285884	22/39 (56%)
itgb2	XP_031749002.1	INB	90..504	CDD:197563	166/465 (36%)
		I-EGF_1	504..532	CDD:408172	12/36 (33%)
		exchanger_TraA	<562..>697	CDD:411343	56/147 (38%)
		Integrin_B_tail	676..755	CDD:400356	23/95 (24%)
		Integrin_b_cyt	780..823	CDD:400871	23/42 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1994
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I854
OMA	1	1.010	-	-		QHG48224
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	1	1.000	-	-		otm48801
Panther	1	1.100	-	-	O	PTHR10082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X739
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080