DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and itgb7

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_002936686.2	Gene:	itgb7 / 100486332	XenbaseID:	XB-GENE-1012435	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	848	Identity:	292/848 - (34%)
Similarity:	429/848 - (50%)	Gaps:	131/848 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GQTDAQKAAKLTAVSTCASKEKCHTCI-QTEGCAWCMQPDF--KGQS---RCYQNTSSL---CPE 79
            |.||           .|.....|:.|| .:..|:||...:|  .|:|   ||......|   |.:
Frog    20 GSTD-----------VCKHTGSCNECILSSASCSWCNAKNFTKSGESEGLRCAVRAELLSRGCDK 73

  Fly    80 EFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYSQSSSGSSSASG 144
            :....|                      .|..:.:.|...|..:...|
Frog    74 DHIIDP----------------------HGSVNVLQGQPLSESADQES----------------- 99

  Fly   145 YEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSMEDDKAKLSTLGD 209
                    ::|:.||::.:.||..|:...::.:.:|||||:|||||||||.||:||...:..||.
Frog   100 --------VIQLHPQAINVKLRPGEQRKFRVEFKRAEGYPIDLYYLMDLSYSMKDDLENMKKLGS 156

  Fly   210 KLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPC----ANCTATYGFHHQMVLDKNITQ 270
            .:.:.:.::|.:.|:|||.||||.::|:|||:...|..||    ..|...:.:.|.:.|..|:|.
Frog   157 DIKKALHKVTKSVHIGFGCFVDKTVLPFVSTVKSKLENPCPLRGEKCQPPFSYRHVLSLTSNLTL 221

  Fly   271 FTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIA 335
            |...|....:|||||.||||.||::||..|...|||| ...|||||::|..||.||||||.|:..
Frog   222 FQMRVSAENISGNLDMPEGGLDAMLQAAVCTDVIGWR-NVTRLLVFASDDVFHSAGDGKLAGIYL 285

  Fly   336 PNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAK 400
            |.||.|||:...||:.|.|.||||:..:.|.:....|..|||||:|.:|.|:.|...|..|:..:
Frog   286 PADGHCHLNRNAEYSQSYLYDYPSVGHLVQVLTAANIQPIFAVTSSVVSTYKALSNLIPKSAVGE 350

  Fly   401 LDNDSSNVVELVKEEYRKISSSVEMKD-NATGDVKITYFSSCLSNGPEV--QTSKCDNLKEGQQV 462
            |..||||||.|:.|.|..:||::.::. |....:.|:|.|.| ||...:  ...:|..::..|.|
Frog   351 LKEDSSNVVNLISEAYNNLSSTINLEHVNLPKGIHISYDSHC-SNSSTLGKAQGQCSGVRINQTV 414

  Fly   463 SFTAQIQLLK--CPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIGYQVQANSCS-G 524
            ||...:.:.|  |.:.    .|:..:..:|..|.:::.:..||:|.|::.     ::.::.|| |
Frog   415 SFDVTLWMDKTLCQQG----KQSFQLRVLGFTEELKVDVEPLCACDCKDK-----ELFSDYCSRG 470

  Fly   525 HGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRGHCVCGACECHKRPN 589
            .|...||||:|.:.:.|..|||.    ..|..||.:|.  |.|...|||.|.|.||.|.|...
Frog   471 LGNYSCGICSCLEGHSGKHCECP----LEKHNNDKACW--SNSHLLCSGHGRCQCGRCACDVS-- 527

  Fly   590 PIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQ------ESNDTCM 648
                ..|..|:||:.||||...:||.|...|.||||.|||..|:|||.|||.      .:|||
Frog   528 ----FRGDLCQCDDTSCERFEGKLCGGITRGVCECGTCKCSDGYTGSACGCSTDTSGCRTNDT-- 586

  Fly   649 PPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTGELKNGD 713
                  :|||||:|||..|||    ...:..:.|.:||.|...|::|.:|.:|:.:..|.||:
Frog   587 ------LCSGHGSCECNKCKC----HPGYYNKWCSECPECQTICKKLTNCAECKAFGKGFLKH-- 639

  Fly   714 DCARNCTQFVPVGVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQGE-LHVYAQENKECP--AKV 775
            :|:.:| |.:.|.:.|..:...: |::||...||...|:.:  |:|: .||..:|.:|..  .|.
Frog   640 NCSSSC-QNINVTLAKAPLTGVR-EKLCKEKGEDFITFLVR--EEGDFFHVTVEEKQETAPVTKH 700

  Fly   776 FMLGIVMGVIAAIVLVGLAILLLWKLLTTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKN 840
            .:||:.:|    ||.:||.|:|.:::...|:||:|:.||:|||.||:|:...||:||.||:|.||
Frog   701 LILGLTLG----IVFIGLLIILAFRITVEIYDRQEYNRFQKERSNAQWNELNNPLYKSATTTVKN 761

  Fly   841 PMY 843
            |.:
Frog   762 PHF 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	158/477 (33%)
		Integrin_B_tail	692..773	CDD:285239	24/83 (29%)
		Integrin_b_cyt	803..843	CDD:285884	22/39 (56%)
itgb7	XP_002936686.2	vWFA	30..455	CDD:381780	158/477 (33%)
		EGF_2	581..610	CDD:285248	14/40 (35%)
		Integrin_B_tail	620..693	CDD:369622	23/78 (29%)
		Integrin_b_cyt	724..764	CDD:370082	22/39 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1994
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	1	1.000	-	-		FOG0001086
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110