DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and itgb4

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_002940020.1	Gene:	itgb4 / 100485847	XenbaseID:	XB-GENE-1013662	Length:	1835	Species:	Xenopus tropicalis

Alignment Length:	816	Identity:	262/816 - (32%)
Similarity:	403/816 - (49%)	Gaps:	114/816 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLMIAILAAIAGQTDAQKAAKLTAVSTCASKE--KCHTCIQT-EGCAWCMQPDFKGQSRC--YQN 72
            ||::.:|...|..:.:.|      .:.|.:..  .|..||:. :.|::|....| ...||  .:|
Frog    11 LLLVLLLGLPASHSQSNK------YNPCVASRATSCSACIRAYKDCSYCADEGF-ASVRCDLAEN 68

  Fly    73 TSSL-CPEE---FAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSFYS 133
            .... |.|.   :..|.:..:|....|.|.::
Frog    69 LRRYGCSERGIVYMRSEVLTQQSYDINTLVSK--------------------------------- 100

  Fly   134 QSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSME 198
                                .|:.||.|.:.||..|:.:..::..:....|||||.|||.|.||.
Frog   101 --------------------TQVAPQRMSMRLRAGEETSFDLNVFEPLDTPVDLYILMDFSHSMS 145

  Fly   199 DDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCANCTATYGFHHQMV 263
            ||.|.|..:|.:|:..:..::.|:.:|||.|||||.:|.....|:.|.:|..:.|..:.|.:.:.
Frog   146 DDLANLKNMGQELANVVSTLSKNYTIGFGKFVDKVTVPQTDMRPEKLKQPWLDSTPPFSFKNVIQ 210

  Fly   264 LDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDG 328
            |..::.:|.||:....:|||||.||||||||:|...|.:|||||:.:..||||||::.|||..||
Frog   211 LTSDVGKFRNELMKEKISGNLDPPEGGFDAILQTAVCTNQIGWRKGSTHLLVFSTESAFHYEADG 275

  Fly   329 K--LGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVE 391
            .  |.|::..||.:|||...|.|||..:|||||:..:.:.:..|.|..|||||....|.|:||.:
Frog   276 MNVLDGILKRNDEQCHLDASGYYTHDIVQDYPSVPTLVRLLAKNNIIPIFAVTNYSYSYYDKLSK 340

  Fly   392 HIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATG---DVKITYFSSCLSNGPEVQTSKC 453
            :.:.|...:|..||||:|||::|.:.:|.|.::::|:.|.   ||.:|      |...:|..:..
Frog   341 YFKVSEIGELKEDSSNIVELLQEAFTQIRSRMDIRDDNTPRAMDVSVT------SETAKVTETGS 399

  Fly   454 DNLKEGQQVSFTAQIQLLK-------CPEDPRDWTQTIHISPVGINEVMQIQLTMLC-SCPCENP 510
            ..:..|:..:|..:::.|:       |...|:|....|.:.|....:.::|..:::| |||||
Frog   400 FQVTRGEVGTFKVKVKALERLGNQHVCELPPQDQGSQILLKPSTFTDGLKIDASLICDSCPCE-- 462

  Fly   511 GSIGYQVQANSCSGHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCRADSTSTTDCSGRG 575
              :..::.:..||.:|..:||.|.|.:.:.|..|.||:||..|    ..||.:.. ||..|||||
Frog   463 --LQKELSSPKCSFNGDFVCGRCECRERWRGVYCNCSSTDTKS----TQSCISPG-STEICSGRG 520

  Fly   576 HCVCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGC 640
            .|:||.|:||.. :|.:...|:.|:.:||.|.|....:|:  |.|.|..|.|.|..||.|.:|.|
Frog   521 ECLCGTCQCHSE-SPTQQYQGEFCQFNNFQCPRFLGYMCN--DRGRCHMGACVCDAGWEGESCQC 582

  Fly   641 QESNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCS--GRCQELKDCVQCQM 703
            ..||.||:...|| :||..|.|.||.|:|  ::..:::...||...:..  |.|::|:.|||||.
Frog   583 PTSNQTCLDRNGG-LCSSRGKCVCGRCQC--DNVSQYTDATCEFSYSLRQLGVCEDLRTCVQCQA 644

  Fly   704 YKTGELKNGDDCARNCTQFVPVGVEKVEIDETKDEQMCKFFDE-DDCKFMFK---YSEQGELHVY 764
            :.||| |.|..| ..|...:.:..|..::||..:.  |.|.|| |||.:.:.   ::.||...|.
Frog   645 WGTGE-KKGTQC-EACEIKIKMVDELKKVDERSEN--CTFRDETDDCTYEYSVDPHAVQGNYTVL 705

  Fly   765 AQENKECPAKVFMLGIVMGVIAAIVLVGLAILLLWK 800
            .:..||||...| |.::..:|..::|:||.:||.||
Frog   706 VKNKKECPPGAF-LWLIPLLIFLMLLLGLLLLLCWK 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	145/479 (30%)
		Integrin_B_tail	692..773	CDD:285239	30/84 (36%)
		Integrin_b_cyt	803..843	CDD:285884
itgb4	XP_002940020.1	Integrin_beta	39..457	CDD:278776	144/477 (30%)
		EGF_2	593..621	CDD:285248	10/30 (33%)
		Integrin_B_tail	633..716	CDD:285239	31/86 (36%)
		Calx-beta	994..1088	CDD:295344
		FN3	1130..1217	CDD:238020
		FN3	1222..1310	CDD:238020
		fn3	1540..1622	CDD:278470
		fn3	1653..1738	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11414
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10082
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110