DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mys and itgb6

DIOPT Version :9

Sequence 1:	NP_001284997.1	Gene:	mys / 44885	FlyBaseID:	FBgn0004657	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001090775.1	Gene:	itgb6 / 100037861	XenbaseID:	XB-GENE-960432	Length:	696	Species:	Xenopus tropicalis

Alignment Length:	781	Identity:	277/781 - (35%)
Similarity:	400/781 - (51%)	Gaps:	106/781 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LALLMIAILAAIA-GQTDAQKAAKLTAVSTCASKEKCHTCIQT-EGCAWCMQPDFKGQ----SRC 69
            :.:.:|.:.|.|. |:...|.:..|.:..||..      |::. ..||||...:|...    .||
Frog     1 MGIELICLFAFILHGKNHVQGSCALGSTMTCGE------CLKLGPHCAWCSHKNFTDSLDIAVRC 59

  Fly    70 --YQNTSSL-CPEEFAYSPITVEQILVNNKLTNQYKAELAAGGGGSAMSGSSSSSYSSSSSSSSF 131
              |:...|. ||.|....|.:..::|.|..||
Frog    60 DTYEVLQSKGCPAESIEFPDSKLEVLRNKPLT--------------------------------- 91

  Fly   132 YSQSSSGSSSASGYEEYSAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKS 196
                       .|.:|.|: :..||.||.:.|.||...:...:|...|.|.||||||||||||.|
Frog    92 -----------EGAQENSS-DATQISPQKLLLKLRPGRELTFQIDVRQTENYPVDLYYLMDLSAS 144

  Fly   197 MEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKNLVEPCAN----CTATYG 257
            ||||...:..||..||:.|.::||||.|||||||:|.:.|::.|:||::..||.:    |..|:|
Frog   145 MEDDLKTIKELGSSLSKEMSKLTNNFQLGFGSFVEKPVSPFIKTVPKDIENPCHSIPYYCLPTFG 209

  Fly   258 FHHQMVLDKNITQFTNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGF 322
            :.|.:.|..|...|...||...:|||:|.|||||||||||..|:.|||||..:..||||.:|...
Frog   210 YKHVLSLTPNAQNFNEIVKKQWISGNIDTPEGGFDAIMQAAVCKEQIGWRNGSLHLLVFVSDGDS 274

  Fly   323 HYAGDGKLGGVIAPNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYE 387
            ||..|.||.|::.||||.|||....||..||:|:|||:.|:.:|:.:|.|.:|||||.:.:.:|:
Frog   275 HYGMDSKLAGIVIPNDGLCHLDSSNEYYMSTVQEYPSVGQLIEKLVENNILLIFAVTKAYVPLYQ 339

  Fly   388 KLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNATGD---VKITYFSSCLSNGPEVQ 449
            .....|.|::...|..||.||::|:...|:::.|.:|::  ..||   :.:::.:.|.:|.....
Frog   340 GYASLIPGATVGLLAKDSGNVLQLIINAYKELRSEIELE--VLGDTEGLSLSFTALCNNNTAIPH 402

  Fly   450 TSKCDNLKEGQQVSFTAQIQLLKCPEDPRDWTQTIHISPVGINEVMQIQLTMLCSCPCENPGSIG 514
            :.||.:||.|.:|||:..|....|.:.    |:.|.|.|||:.|.:::::...|||.|..
Frog   403 SKKCQHLKVGDRVSFSVSITSASCEKH----TRHIVIKPVGLEESLEVEIQSECSCQCHR----- 458

  Fly   515 YQVQANSCS-GHGTSMCGICNCDDSYFGNKCECSATDLTSKFANDTSCR-ADSTSTTDCSGRGHC 577
             :.:::.|| |:|...||:|.|...|.|:.|:|:...|     |.:||: .||     |.|||.|
Frog   459 -EERSSECSKGNGALECGVCVCYPPYLGDHCQCNEGSL-----NSSSCKELDS-----CGGRGEC 512

  Fly   578 VCGACECHKRPNPIEIISGKHCECDNFSCERNRNQLCSGPDHGTCECGRCKCKPGWTGSNCGCQE 642
            .||.|.|:  |:....|.|.|||||:|||.|:|..:|:|  ||.||||.|.|..||:||.|.|..
Frog   513 YCGQCICY--PSVYGRIYGSHCECDDFSCLRHRGVICAG--HGDCECGECICHSGWSGSYCNCTM 573

  Fly   643 SNDTCMPPGGGEICSGHGTCECGVCKCTVNDQGRFSGRHCEKCPTCSGRCQELKDCVQCQMYKTG 707
            ...||:...|. :|||.|.|.||.|.|   :....||..||:||||...|...:.||:|.:....
Frog   574 DTQTCISENGA-LCSGRGECVCGKCVC---NNPEVSGDVCERCPTCGDPCSSKRACVECHLLPAE 634

  Fly   708 ELKNGDDCARNCTQFVPVGVEKVEIDETKDEQM-CKFFDEDDCKFMFKYS--EQGELHVYAQENK 769
            |.:  ::|...| :.|...|...| |.::|:.: |....|::|...|..:  |.|:..:|..:.|
Frog   635 EQQ--EECEETC-KLVDATVSNAE-DFSEDKSISCSLQGENECAITFGMATDEHGKKVIYNIQQK 695

  Fly   770 E 770
            :
Frog   696 K 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mys	NP_001284997.1	INB	45..505	CDD:197563	170/474 (36%)
		Integrin_B_tail	692..773	CDD:285239	20/82 (24%)
		Integrin_b_cyt	803..843	CDD:285884
itgb6	NP_001090775.1	Integrin_beta	30..454	CDD:278776	172/480 (36%)
itgb6	NP_001090775.1	Integrin_B_tail	619..695	CDD:285239	19/79 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1994
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223415at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48801
Panther	1	1.100	-	-	O	PTHR10082
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110