DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rhi and CBX4

DIOPT Version :9

Sequence 1:	NP_536794.1	Gene:	rhi / 44879	FlyBaseID:	FBgn0004400	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_003646.2	Gene:	CBX4 / 8535	HGNCID:	1554	Length:	560	Species:	Homo sapiens

Alignment Length:	382	Identity:	79/382 - (20%)
Similarity:	134/382 - (35%)	Gaps:	101/382 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DHVEEYVVEKILGKRFVNGRPQVLVKWSGFPNENNTWEPLENVGNCMKLVSDFESEVFRLHRKAA 83
            :||  :.||.|..||...||.:.||||.|:..:.|||||.||:.:...|:: |:      :|:..
Human     8 EHV--FAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIA-FQ------NRERQ 63

  Fly    84 AKSVGKSKSSPSSSGPLITENGPSSSKK-----------TQQHSK---SVQAKNTAGMSKMNQKK 134
            .:.:|..|..|... ||:.: .|:.:::           |...:|   ..|.|......::|.||
Human    64 EQLMGYRKRGPKPK-PLVVQ-VPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKK 126

  Fly   135 ----GKNIKKTAGKIKDIENYPKTQMPSTS-----QVSTDSTEVFDGNPSATTTNMIKSPRIQSL 190
                ..:.|:.||         |...|..|     |:::.....:..:|        |...:|..
Human   127 HHQYQPHSKERAG---------KPPPPGKSGKYYYQLNSKKHHPYQPDP--------KMYDLQYQ 174

  Fly   191 FSDLNLIEPTKDKDVGDTSLKTPPKSRRLIEFPQREDA--------PLSSKHVSPMLIRKESQPL 247
            ........||    ..|...|:.|..:    :.|...|        ||:....:|
Human   175 GGHKEAPSPT----CPDLGAKSHPPDK----WAQGAGAKGYLGAVKPLAGAAGAP---------- 221

  Fly   248 QSSCTDDSDLGESSSSMSLP--TVSSTSSEKSIKVTKSEPKTLGQIKFSSRSSDGGHAASSLGAP 310
                ...|:.|..:..|..|  .|:.......:|:.|::.|....:...|:..:.|..|..:
Human   222 ----GKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKI--- 279

  Fly   311 KEGDIGLDLSGSDSMDSEVESMRRCPRRKRKKTYPDWKFPEMTKPFGVNRGLDLDKI 367
            |.|::             .|...|.|..|::..  |.:.|...:.|....|.:..|:
Human   280 KSGEV-------------AEGEARSPSHKKRAA--DERHPPADRTFKKAAGAEEKKV 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rhi	NP_536794.1	CHROMO	22..72	CDD:237991	20/49 (41%)
rhi	NP_536794.1	ChSh	357..411	CDD:294039	2/11 (18%)
CBX4	NP_003646.2	Interaction with BMI1	1..539		79/382 (21%)
		Involved in interaction with H3C15 and H3C1. /evidence=ECO:0000269\|PubMed:18927235	1..75		26/75 (35%)
		CHROMO	10..62	CDD:214605	23/60 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..152		13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..243		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..404		10/56 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..528
		Involved in interaction with H3C15 and RNF2. /evidence=ECO:0000269\|PubMed:18927235	531..556
		CBX7_C	<538..559	CDD:319236
		Interaction with RNF2	540..560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920