DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rhi and Cdyl

DIOPT Version :9

Sequence 1:	NP_536794.1	Gene:	rhi / 44879	FlyBaseID:	FBgn0004400	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_034011.1	Gene:	Cdyl / 12593	MGIID:	1339956	Length:	593	Species:	Mus musculus

Alignment Length:	355	Identity:	81/355 - (22%)
Similarity:	142/355 - (40%)	Gaps:	75/355 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 APPNDHVEEYVVEKILGKR-FVNGRPQVLVKWSGFPNENNTWEPLENVGNCMKLVSDFESEVFRL 78
            |.|.....|..||.|:.|| ...|:.:.||:|.|:.:|::||||.:::.||.:.:.||.    |.
Mouse    47 ASPAIQDAETQVESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFN----RR 107

  Fly    79 H--RKAAAKSVGKSKSSPSSSGPLITENGPSSSKKT---------QQHSKSVQ--------AKNT 124
            |  |:........|::|||::...|:.:..|:..||         ...|||.|        .||.
Mouse   108 HNERQKEGSLARASRASPSNARKQISRSTHSTLSKTNSKALVVGKDHESKSSQLLAASQKFRKNP 172

  Fly   125 AGMSKMNQKKGKNIKKTAGKIKDIENYPKTQMPSTSQVSTDSTEVFDGNPSATTTNMIKSPRIQS 189
            |  ..:..:|..::.|:..||.    .||:  |...:.|.|.   |.|          :||
Mouse   173 A--PSLANRKNMDLAKSGIKIL----VPKS--PVKGRTSVDG---FQG----------ESP---- 212

  Fly   190 LFSDLNLIEPTKDKDVGDTSLK--TPPKSRRLIEFPQREDAPLSSKHVSPMLIRKESQPLQSSCT 252
                 ..::|. |:...||...  |..|....:..|..|.|.:.|:.....|:.:.|.|:.::..
Mouse   213 -----EKLDPV-DQGAEDTVAPEVTAEKPTGALLGPGAERARMGSRPRIHPLVPQVSGPVTAAMA 271

  Fly   253 DD---SDLGESSSSMSLPTVSSTSSEKSIK-VTKSEPKTLG---------QIKFSSRSSDGGHAA 304
            ..   :..|.|....:|....:.:.:.|:. ||..:.|.:.         :::||.|.::..:..
Mouse   272 TGLAVNGKGTSPFMDALAANGTVTIQTSVTGVTAGKRKFIDDRRDQPFDKRLRFSVRQTESAYRY 336

  Fly   305 SSLGAPKEGD-----IGLDLSGSDSMDSEV 329
            ..:...|:..     :....|.::|::.||
Mouse   337 RDIVVRKQDGFTHILLSTKSSENNSLNPEV 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rhi	NP_536794.1	CHROMO	22..72	CDD:237991	19/50 (38%)
rhi	NP_536794.1	ChSh	357..411	CDD:294039
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		CHROMO	55..109	CDD:214605	21/57 (37%)
		Interaction with EZH2. /evidence=ECO:0000250\|UniProtKB:Q9Y232	56..304		67/282 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..158		10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..223		8/45 (18%)
		crotonase-like	339..535	CDD:119339	5/28 (18%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810