DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sub and KIF20B

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001271188.1	Gene:	KIF20B / 9585	HGNCID:	7212	Length:	1820	Species:	Homo sapiens

Alignment Length:	750	Identity:	202/750 - (26%)
Similarity:	315/750 - (42%)	Gaps:	178/750 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VPRREVRSFLMARDPSIDRRFRPRPNKKMRLFDNIQESEEESFSEYSDTESEYKYQSSEATEGAS 73
            |||   .|::.:.||.      .||::..  ||.|:......||..:.......::|.:..
Human    10 VPR---PSYVFSADPI------ARPSEIN--FDGIKLDLSHEFSLVAPNTEANSFESKDYL---- 59

  Fly    74 CATSAADSSNVETGPQVFLRLRPVKDASK-------AYIVSEEANVL-ITSCKVDSTS-NNVNRM 129
                           ||.||:||...:.|       .:|:..:..|| ...|.:...| .:..:|
Human    60 ---------------QVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQM 109

  Fly   130 EKHFGFTSIFDSTVGQRDIYDTCVGPKI---MEEECVTIMTYGTSGSGKTYTLLGDDVRAGIIPR 191
            .:.|.|:.:|.....|::.:..|:...:   ::.:...|.|||.:.||||||..|.:...||:||
Human   110 AQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPR 174

  Fly   192 ALENIFTIYQDTVFRSPKLKLING-SIVFLQDDASLKELQIRKKLLDLCPDISAHH--------- 246
            .|..:|...|:.::....||.... ..:.|..:...:|:..:..||....:::.|:
Human   175 TLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGS 239

  Fly   247 -------QRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNL 304
                   ...::.|..........:..:...|||||.|||||.:|||..  |...|..:  ||.|
Human   240 LTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFV--PVSSKFQK--RKML 300

  Fly   305 KIVGN-KGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKY--- 365
            ::..: ||:.|||.|..:.|:.|:||.|||:||.:..:.|.|.:|..|||||.:|||.||:.
Human   301 RLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDS 365

  Fly   366 NRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIP 430
            ..|.:...|....||||||||...|...|.||:|..||||||:.||:|::.....:|.|....:|
Human   366 EMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVP 430

  Fly   431 YRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKE-----------P 484
            :|:||||...|:...||.|:.|||.::.....|:|.||||.|::||:.:...:           |
Human   431 FRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGP 495

  Fly   485 V------------------IKQHRVSYCGFMEFSKMSTCEGGDYTKELED----ENVRLQLEIEQ 527
            |                  :|:..:|:    |.|.....|..|..:|||:    :||..:|..|.
Human   496 VKSSQDVSLDSNSNSKILNVKRATISW----ENSLEDLMEDEDLVEELENAEETQNVETKLLDED 556

  Fly   528 LKYDHVLQ--MQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLI----------------AQ 574
            |  |..|:  ...:..:.:|:|.    ::|::.||:..:|.::||.:                ||
Human   557 L--DKTLEENKAFISHEEKRKLL----DLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQ 615

  Fly   575 RESEF--MLSSQRRRYEEQIE-------DL-----------------KDEIEELKNPASDTDISD 613
            ||::|  .|..:|...||..|       ||                 |.|.||..|.....||.|
Human   616 READFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVGFEDIID 680

  Fly   614 ------------------------DPNESKSPIEI 624
                                    ||.|:.:.:|:
Human   681 SLQDNVADIKKQAEIAHLYIASLPDPQEATACLEL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	137/420 (33%)
		Kinesin	93..479	CDD:278646	135/418 (32%)
		GBP_C	<512..603	CDD:303769	34/138 (25%)
		coiled coil	576..586	CDD:293879	3/11 (27%)
		coiled coil	592..603	CDD:293879	7/34 (21%)
KIF20B	NP_001271188.1	KISc_KIF23_like	57..477	CDD:276819	137/442 (31%)
		Kinesin	64..479	CDD:278646	135/418 (32%)
		Smc	629..1455	CDD:224117	17/86 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	829..866
		Necessary and sufficient for interaction with SHTN1. /evidence=ECO:0000250\|UniProtKB:Q80WE4	1050..1107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1247..1275
		DUF342	<1268..1357	CDD:302792
		Interaction with PIN1. /evidence=ECO:0000269\|PubMed:11470801	1560..1820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1760..1781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950