DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sub and KIF23

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001354734.1	Gene:	KIF23 / 9493	HGNCID:	6392	Length:	974	Species:	Homo sapiens

Alignment Length:	641	Identity:	176/641 - (27%)
Similarity:	279/641 - (43%)	Gaps:	115/641 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QSSEATEGASCATSAADSSNVETGPQVFLRLRPV--KDASKAYIVSEEANVLITSCKVDSTSNNV 126
            :|:.|.............:|::....|:.|:||:  .|......|.....|.:.:.:....:.|.
Human     2 KSARAKTPRKPTVKKGSQTNLKDPVGVYCRVRPLGFPDQECCIEVINNTTVQLHTPEGYRLNRNG 66

  Fly   127 NRMEKHFGFTSIFDSTVGQRDIYDTCVGP---KIMEEECVTIMTYGTSGSGKTYTLLGDDVRAGI 188
            :..|..:.|..:|.:...|::::|....|   .::..:...:.|||.:|||||:|:.|.....|:
Human    67 DYKETQYSFKQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGSPGEGGL 131

  Fly   189 IPRALENIFTIY-----QDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQR 248
            :||.|:.||...     :..||:|...   |...:..:.|| |.|.|.|:.:.:  |..|:..::
Human   132 LPRCLDMIFNSIGSFQAKRYVFKSNDR---NSMDIQCEVDA-LLERQKREAMPN--PKTSSSKRQ 190

  Fly   249 L---------------KQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLL------AIPPK 292
            :               .:.:|.|.::.          |:||::||||..:||||      .|.||
Human   191 VDPEFADMITVQEFCKAEEVDEDSVYG----------VFVSYIEIYNNYIYDLLEEVPFDPIKPK 245

  Fly   293 QDKLGEVPRKNLKIV--------GNKGH-VFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVN 348
            .:.. ..|.:|...|        .:|.| :::.|.|.|.|.|:|||..:...||::...|:|.:|
Human   246 WNSC-STPMRNTDFVPPQSKLLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLN 309

  Fly   349 ANSSRSHCVFTVDILK-----------YNRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKN 402
            ..|||||.||.:.:::           ..:..||. |.....|||||||.|.|...|.||:||.|
Human   310 RESSRSHSVFNIKLVQAPLDADGDNVLQEKEQITI-SQLSLVDLAGSERTNRTRAEGNRLREAGN 373

  Fly   403 INTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENL 467
            ||.|||.|..|:|.....|......::||||||||.|.:....|:.|:.|||.|.|..:.|||||
Human   374 INQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDYEENL 438

  Fly   468 NVLNFASIAKNIIFKEPVIKQHRVSYCG-------------------------FMEFSKMSTCEG 507
            .|:.||.:.:.:....||.|    :.||                         ...|..:.:||
Human   439 QVMRFAEVTQEVEVARPVDK----AICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSFPPLPSCE- 498

  Fly   508 GDYTKELEDENVRLQLEIEQLKYDHVLQMQLLEE--KLRRELTATYQEIIQNNKKQYEDECEKKL 570
               ..::.||....:| ||.|:..|.|:..:::|  |......|..|| ..|.....|:..:.||
Human   499 ---ILDINDEQTLPRL-IEALEKRHNLRQMMIDEFNKQSNAFKALLQE-FDNAVLSKENHMQGKL 558

  Fly   571 LIAQRESEFMLSSQR---RRYEEQIEDLKDEIEELKNPASDTDISDDPNESKSPIE 623
                .|.|.|:|.|:   .|.|::.:.|:.:||.|:.  :.|...:|....:..:|
Human   559 ----NEKEKMISGQKLEIERLEKKNKTLEYKIEILEK--TTTIYEEDKRNLQQELE 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	134/438 (31%)
		Kinesin	93..479	CDD:278646	133/436 (31%)
		GBP_C	<512..603	CDD:303769	27/95 (28%)
		coiled coil	576..586	CDD:293879	5/12 (42%)
		coiled coil	592..603	CDD:293879	3/10 (30%)
KIF23	NP_001354734.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		2/17 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	7..11		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..705
		Interaction with ARF6. /evidence=ECO:0000269\|PubMed:22522702	808..925
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..942
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	955..974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950