DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sub and kif23

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	XP_012814357.1	Gene:	kif23 / 496517	XenbaseID:	XB-GENE-999865	Length:	970	Species:	Xenopus tropicalis

Alignment Length:	636	Identity:	182/636 - (28%)
Similarity:	289/636 - (45%)	Gaps:	122/636 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SSNVETGPQVFLRLRPV--KDASKAYIVSEEANVLI---TSCKVDSTSNNVNRMEKHFGFTSIFD 140
            |:|.:....|:.|:||:  .|......|..|..|.:   ..||   .:.|....|..:.:..:|.
Frog    20 STNQKDPVGVYCRVRPLSPSDQECCIEVINETTVQLHPPDGCK---ANRNGEYKETQYSYKQVFG 81

  Fly   141 STVGQRDIYDTCVGPKIMEEECV-----TIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIY 200
            :.|.|::::|....|.:  |:.:     .:.|||.:|||||:|:.|.....|::||.|..||...
Frog    82 TQVTQKELFDVVSRPLV--EDVIRGKNGLLFTYGVTGSGKTHTMTGSPGDGGLLPRCLSMIFNSI 144

  Fly   201 -----QDTVFRSPKLKLINGSIVFLQDDASL--KELQIRKKLLDLCP------------DISAHH 246
                 :..||: |..|  ||..|..:.||.|  ::.:::.:|:...|            .|:...
Frog   145 GNFQAKRYVFK-PDDK--NGMDVQNEVDALLERQKREVQPQLITRTPLSRQRMDPEFADMINIQE 206

  Fly   247 QRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLL------AIPPKQDKLGE----VPR 301
            |...:.:|.|.::.          |:||::||||..:||||      .|.||.:..|.    :|.
Frog   207 QCKVEDVDEDSVYS----------VFVSYIEIYNNYIYDLLEEVPLDPIKPKWNTPGRNAEFIPP 261

  Fly   302 KNLKIVGNKGH-VFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTV----- 360
            ::..:..:..| ::|.|.|.|.|.|:|||..:...||:|...|:|.:|..|||||.||.:
Frog   262 QSRILREDLNHNMYIAGCTEVEVKSTEEAFDIFWKGQKRRRIANTQLNRESSRSHSVFMIKLAQA 326

  Fly   361 ------DILKYNRSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAAST 419
                  |.:...|..||. |.....|||||||.|.|...|.||:||.|||.|||.|..|::....
Frog   327 PLDADGDNVLQEREQITL-SQLSLVDLAGSERTNRTKAEGSRLREAGNINQSLMTLRTCIEVLRE 390

  Fly   420 VQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEP 484
            .|......::||||||||.|.:....|:.|:.|||.|.|....:||:|.|:.||.:.:.:....|
Frog   391 NQLCGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKADDFEESLQVMRFAEMTQEVEVARP 455

  Fly   485 VIKQHRVSYCGFM------------EFSKMSTCEGGDYTKELEDE---NVRLQ-------LEIEQ 527
            |.|    ..||..            |.::.....||....:.||:   .:.:|       .|:..
Frog   456 VDK----PICGLTPGRRYRNQAFKEELTRRLEDRGGPINGDAEDQAVVEILIQSFPPLPSCELLD 516

  Fly   528 LKYDHVLQ--MQLLEEKLR-RELTA--------TYQEIIQNNKKQYEDECEKKLLIAQ---RESE 578
            ...||.|.  :::||::.| |::.|        |::.::|:    .......|..|||   .|.:
Frog   517 ANDDHTLPKLIEVLEKRRRIRQMMAEEFNKNVSTFRAMLQD----LNGVVTAKENIAQGRMTEKD 577

  Fly   579 FMLSSQR---RRYEEQIEDLKDEIEELKNPASDTDISDDPNESKSPIEILD 626
            .|::||:   .|.:::|:.|:.:|:.|:   ..|.|.:|  |.::..:.||
Frog   578 KMIASQKSEMERLDKKIKTLEYKIDILE---KTTTIYED--EKRTMQQDLD 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	139/438 (32%)
		Kinesin	93..479	CDD:278646	138/436 (32%)
		GBP_C	<512..603	CDD:303769	26/117 (22%)
		coiled coil	576..586	CDD:293879	4/12 (33%)
		coiled coil	592..603	CDD:293879	3/10 (30%)
kif23	XP_012814357.1	KISc_KIF23_like	25..448	CDD:276819	139/441 (32%)
		CwlO1	543..>694	CDD:226400	21/90 (23%)
		PHA03307	<696..>821	CDD:223039
		MKLP1_Arf_bdg	811..911	CDD:374613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950