DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sub and zgc:56231

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_998353.1	Gene:	zgc:56231 / 406257	ZFINID:	ZDB-GENE-040426-1914	Length:	810	Species:	Danio rerio

Alignment Length:	660	Identity:	165/660 - (25%)
Similarity:	297/660 - (45%)	Gaps:	121/660 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IQESEEESFSEYSDTESEYKYQSSEATEGASCATSAADSSNVETGPQ--VFLRLRPV------KD 99
            :..:|:........|..|..:.:.....|.|..||.::::.:....|  |:|::||.      .:
Zfish     5 VDMTEDTVLVAMESTACEPHHVALPELSGVSSITSQSENAEIHEQQQLRVYLKVRPFSVEELKNN 69

  Fly   100 ASKAYIVSEEANVLIT-----SCKVDSTSNNVNRMEKHFGFTSIFDSTVGQRDIYDTCVGPKI-- 157
            ..:..:|.|::..::.     |..:.|:...:.:....|.|:.||.....|.:.::..:..::
Zfish    70 EDQGCVVLEDSETIVLHAPKGSASMKSSEKGIGQQVYKFSFSQIFGPNCNQTEFFEGTISSQVQA 134

  Fly   158 -MEEECVTIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQDTVFRSPKLK--------LI 213
             :..:...:.:||.:.:|||||:.|.....||:|||||.:|.......:....||        .:
Zfish   135 FLHGKNALVFSYGVTNAGKTYTIQGSPKDPGILPRALEVLFKHIGGRQYEHMDLKPYLSSDVQKL 199

  Fly   214 NGSIVFLQDDAS------LKE----LQIRKK-----LLDLC-PDISAHH--QRLKQVIDGDHMFE 260
            :..:|.|:.:|.      |||    .::||:     :..|. .::|..|  .....:.|..|.|.
Zfish   200 DSELVKLERNAKAALFSLLKEDPEPTKLRKRSSTSSINSLSFSNVSYDHTVDSADGMADEAHCFY 264

  Fly   261 TKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIV-GNKGHVFIKGLTSVFVT 324
            :         |||:|.|||||.|||||. |.:..|...  |..|::. .:.|..:|:.|..|.|.
Zfish   265 S---------VWVAFYEIYNEHVYDLLQ-PAQSSKTKR--RAALRVCEDSTGSSYIRDLRWVNVQ 317

  Fly   325 SSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSGITTQSSYKFCDLAGSERVNN 389
            ::||..::||:|.:..:.|:|.:|.:|||||.:||:.:::...:.:...|....||||||||.|.
Zfish   318 NTEEFSKVLRVGNKNRSAAATKMNQSSSRSHSIFTIKLIRIEGADVQALSELSLCDLAGSERCNK 382

  Fly   390 TGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIV 454
            |.|.|.|||||.|||.||::||:|:.|....|..:....:|:|:||||.|.|....|:.:.:|||
Zfish   383 TKTFGDRLKEAGNINNSLLILGKCIAALRNNQGFRTKSYVPFRESKLTRLFQGMFCGRGRASMIV 447

  Fly   455 TVTPLDKYYEENLNVLNFASIAKNI-----------------------IFKEPVIKQHRVSYCGF 496
            .:......|:|.|:|:.|:::||.:                       :.|..||....|.  .:
Zfish   448 NINQCASTYDETLHVMKFSAVAKQVLQVIPPRSLESLAPRIVGLDGKPLLKNGVIDDQAVD--DY 510

  Fly   497 MEFSKMSTCEGGDYT---------------------------------KELEDENVRLQLEIEQL 528
            :...::...:..|.:                                 ||:.|..::..:|.|:|
Zfish   511 LSEEELLDGDEADMSILPQEELVNLVESLRVKLLAERRKNLLQEIQIRKEMGDAMLQQIMEAEEL 575

  Fly   529 KYDHVLQMQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIE 593
               |..||:.|:|....::.:|: |:.:...|::..:|..:.|    |.:::...:.:..:|::|
Zfish   576 ---HSRQMEDLKESYEEKMDSTF-EMYKEALKEHAYQCALERL----EEDYIPIEEYKEEQERVE 632

  Fly   594 DLKDEIEELK 603
            .|:..:.||:
Zfish   633 VLEKRVCELE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	129/430 (30%)
		Kinesin	93..479	CDD:278646	128/426 (30%)
		GBP_C	<512..603	CDD:303769	21/90 (23%)
		coiled coil	576..586	CDD:293879	1/9 (11%)
		coiled coil	592..603	CDD:293879	3/10 (30%)
zgc:56231	NP_998353.1	KISc_KIF23_like	50..470	CDD:276819	129/431 (30%)
		Kinesin	58..472	CDD:278646	128/425 (30%)
		CREPT	<550..>638	CDD:293174	20/95 (21%)
		TBPIP	<696..>757	CDD:284512
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3418
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	1	1.000	-	-		FOG0006202
OrthoInspector	1	1.000	-	-		otm25532
orthoMCL	1	0.900	-	-		OOG6_107198
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870