DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sub and Klp68D

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001261726.1	Gene:	Klp68D / 39332	FlyBaseID:	FBgn0004381	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	138/543 - (25%)
Similarity:	222/543 - (40%)	Gaps:	138/543 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 QVFLRLRPVKDASKAYIVSEEANVLITS--CKVDSTSNNVNRMEKHFGFTSIFDSTVGQRDIYDT 151
            ||.:|.||:.:..::....|..||....  .::.:..:......|.|.:.:.:|::..|..:|..
  Fly    21 QVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDASATQTTLYHE 85

  Fly   152 CVGP---KIMEEECVTIMTYGTSGSGKTYTL---LGDDVRAGIIPRALENIFTIYQDTVFRSPKL 210
            .|.|   .::|.....|..||.:|:|||:|:   .|:|...|||||..|.|:.
  Fly    86 VVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWL------------ 138

  Fly   211 KLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFETKASTDVSVLVWVSF 275
                                                          |:..|:   :...||.||:
  Fly   139 ----------------------------------------------HINRTE---NFQFLVDVSY 154

  Fly   276 VEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRLGQQRS 340
            :|||.|.:.|||  .|..        |:|::......|::..|.::...|.|:.::::::|.:..
  Fly   155 LEIYMEELRDLL--KPNS--------KHLEVRERGSGVYVPNLHAINCKSVEDMIKVMQVGNKNR 209

  Fly   341 TYASTSVNANSSRSHCVFTVDILKYNRSGITTQ-SSYKFCDLAGSERVNNTGTSGLRLKEAKNIN 404
            |...|::|.:|||||.:|.:.|...:....|.: ......|||||||.:.||.|..|||||..||
  Fly   210 TVGFTNMNEHSSRSHAIFMIKIEMCDTETNTIKVGKLNLIDLAGSERQSKTGASAERLKEASKIN 274

  Fly   405 TSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNV 469
            .:|..||..:.|.:     :::..:||||||||.|||.:|.|..|..||..:.|.:..|.|.|..
  Fly   275 LALSSLGNVISALA-----ESSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNYNETLTT 334

  Fly   470 LNFASIAKNIIFKEPVIKQHRVSYCGFMEFSKMSTCEGGDYTKELEDENVRL---QLEIEQLKYD 531
            |.:||.||: |..:|:                          |..:.::.:|   |.|||:||..
  Fly   335 LRYASRAKS-IQNQPI--------------------------KNEDPQDAKLKEYQEEIERLKRL 372

  Fly   532 HVLQMQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLK 596
            ...|.|...||   ::||..|.:.:..|:....|....|                    |:..::
  Fly   373 IGPQQQQRSEK---QVTAKKQRVKKPKKETVTKEMSDSL--------------------QVSTIE 414

  Fly   597 DEIEELKNPASDTDISDDPNESK 619
            ..:|:..:|......||..||::
  Fly   415 QPVEDDSDPEGAESESDKENEAE 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	109/396 (28%)
		Kinesin	93..479	CDD:278646	109/394 (28%)
		GBP_C	<512..603	CDD:303769	20/93 (22%)
		coiled coil	576..586	CDD:293879	0/9 (0%)
		coiled coil	592..603	CDD:293879	1/10 (10%)
Klp68D	NP_001261726.1	Motor_domain	18..344	CDD:277568	111/399 (28%)
		KISc	20..351	CDD:214526	113/432 (26%)
		GBP_C	<479..576	CDD:303769
		coiled coil	547..558	CDD:293879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437859
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940