Protein Alignment sub and Kif14

DIOPT Version :10

• Sequence 1: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: XP_006529793.2
• Gene: Kif14 / 381293
• MGIID: 1098226
• Length: 1717
• Species: Mus musculus
• Alignment Length: 659
• Identity: 165/659 - (25%)
• Similarity: 269/659 - (40%)
• Gaps: 189/659 - (28%)

  Fly    10 PRREVRSFLMARDPSIDRRFRPRPNKKMRLFDNIQES--------EEESFSEYSDTESE-YKYQS 65
            |:....|.|..|..|  .|.:|||  |..||.|.:||        ||.|..:.:.||.: .|.::
Mouse   331 PKSPALSTLKNRIAS--PRVKPRP--KSSLFANKRESSRESTLPPEENSLVQKTFTEPDSLKVEN 391

  Fly    66 SEATEGASCATSAADSSNVETGPQVFLRLRPVKDASKAYIVSEEANVLITSCKVDSTSNNVNRME 130
            |:.|                    |.:|:||.....|    :|:|:.::.:...:.|..:.: |:
Mouse   392 SQVT--------------------VAVRVRPFSKREK----TEKASQVVFTNGEEITVEHPD-MK 431

  Fly   131 KHFGFTSIFDST-----------VGQRDIYDTCVGP---KIMEEECVTIMTYGTSGSGKTYTLLG 181
            :.:.|  |:|.:           ..|..:|:|...|   :..|.....:..||.:||||:||::|
Mouse   432 QVYSF--IYDVSFWSFDECHPGYASQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMG 494

  Fly   182 DDVRAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHH 246
            .:...|||||..|::|.                               ||.|
Mouse   495 LNEEPGIIPRFCEDLFA-------------------------------QIAK------------- 515

  Fly   247 QRLKQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKG 311
                           |.:::||..:.:||.|:|||.::|||...      ||..::...:...:.
Mouse   516 ---------------KQTSEVSYHLEMSFFEVYNEKIHDLLVCK------GENGQRKQPLRAREH 559

  Fly   312 HV---FIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTV-------DILKYN 366
            .|   :::||:...|:|..:....|.||.::...|:|.:|..|||||.|||:       ::::..
Mouse   560 PVSGPYVEGLSMNVVSSYSDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEVVEGE 624

  Fly   367 RSGITTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPY 431
            .......|.....|||||||.:...:||.||||..:||.||:.||:.:.|.|.....|.. .|||
Mouse   625 EHDHRITSRINLVDLAGSERCSTAHSSGQRLKEGVSINKSLLTLGKVISALSEQANGKRV-FIPY 688

  Fly   432 RDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHRVSYCGF 496
            |:|.||.||:.:|.|..|.|||.||:|.....||.|:.|.:|:.|:.|:
Mouse   689 RESTLTWLLKESLGGNSKTAMIATVSPAASNIEETLSTLRYATQARLIV---------------- 737

  Fly   497 MEFSKMSTCEGGDYTKELEDENVR----LQLEIEQLKYDHVLQMQLLEEK---LRRELTATYQEI 554
                        :..|..||.|.:    |:.|||:||........:..|:   .|:|:|:...::
Mouse   738 ------------NIAKVNEDMNAKLIRELKAEIEKLKAAQRSNRNIDPERYRLCRQEITSLRMKL 790

  Fly   555 IQNNK---------KQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLKDEIEELKNPASDTD 610
            .|..:         |:..::.||:.|  |...|...:....:.:..:.:|             .:
Mouse   791 HQQERDMAEIQRVWKEKFEQAEKRKL--QETKELQKAGVTFQMDNHLPNL-------------VN 840

  Fly   611 ISDDPNESK 619
            :::||..|:
Mouse   841 LNEDPQLSE 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_611260.1	KISc	89..477	CDD:276812	115/411 (28%)
		GBP_C	<512..603	CDD:293879	22/106 (21%)
		coiled coil	576..586	CDD:293879	1/9 (11%)
		coiled coil	592..603	CDD:293879	1/10 (10%)
Kif14	XP_006529793.2	KISc_KIF1A_KIF1B	392..743	CDD:276816	120/471 (25%)
		Kinesin_assoc	740..859	CDD:465047	25/125 (20%)
		FHA_KIF14	829..936	CDD:438759	4/34 (12%)
		SMC_prok_B	<937..>1109	CDD:274008