DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sub and Klp59C

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	124/494 - (25%)
Similarity:	192/494 - (38%)	Gaps:	127/494 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 REVRSFLMAR-----------DPSIDRRFRPRPNKKMRLFDNIQESEEESFSEYSDTESEYKYQS 65
            ||.|....||           ||.       .||.::.....:|..:.||          .:.:|
  Fly   129 RERRREAQARTRLDREQGKNEDPG-------NPNWEVARMIRLQREQMES----------QRVRS 176

  Fly    66 SEATEGASCATSAADSSNVETGPQVFLRLRPVKDASKAYIVSEEANVLITSCK----VDSTSNNV 126
            ....|..:|...           .|.:|.||::   :..:...|.:|:....|    |.....:|
  Fly   177 GTTNERINCHQI-----------MVCVRKRPLR---RKELADREQDVVSIPSKHTLVVHEPRKHV 227

  Fly   127 NR---MEKH-FGFTSIFDSTVGQRDIYDTCVGP---KIMEEECVTIMTYGTSGSGKTYTLLGDDV 184
            |.   :|.| |.|..:||.......:|:....|   .|.:....|...||.:|||||||:.|.
  Fly   228 NLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQ-- 290

  Fly   185 RAGIIPRALENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRL 249
            ..|....:::.|:.:....||                  ::||.:...|
  Fly   291 FPGRHQSSMDGIYAMAAKDVF------------------STLKTVPYNK---------------- 321

  Fly   250 KQVIDGDHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKG-HV 313
                             :::.|:.||.|||...|:||| :|.|         ..|:::.::. .|
  Fly   322 -----------------LNLKVYCSFFEIYGTRVFDLL-MPGK---------PQLRVLEDRNQQV 359

  Fly   314 FIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSGITTQSSYKF 378
            .:.|||...|.::.|.|.||.||....|...||.|:.|||||.||.: :|: :.:|......:..
  Fly   360 QVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQI-VLR-SAAGEKLHGKFSL 422

  Fly   379 CDLAGSER-VNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQA 442
            .||||:|| .:|:........|...||.||:||..|:.|..     :.:..:|:|.||||.:|:.
  Fly   423 IDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALG-----RQSSHLPFRGSKLTQVLRD 482

  Fly   443 ALLG--KEKLAMIVTVTPLDKYYEENLNVLNFASIAKNI 479
            :.:|  |.|..||..::|.....|..||.|.:|...|.:
  Fly   483 SFIGGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKEL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	108/402 (27%)
		Kinesin	93..479	CDD:278646	108/400 (27%)
		GBP_C	<512..603	CDD:303769
		coiled coil	576..586	CDD:293879
		coiled coil	592..603	CDD:293879
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	108/415 (26%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	107/399 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940