Protein Alignment sub and Kif20b

DIOPT Version :10

• Sequence 1: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: XP_006231343.1
• Gene: Kif20b / 309523
• RGDID: 1308497
• Length: 1781
• Species: Rattus norvegicus
• Alignment Length: 752
• Identity: 198/752 - (26%)
• Similarity: 314/752 - (41%)
• Gaps: 182/752 - (24%)

  Fly     9 VPRREVRSFLMARDPSIDRRFRPRPNKKMRLFDNIQESEEESFSEYSDTESEYKYQSSEATEGAS 73
            |||   .|::.:.||.      .||::..  ||.::......||                   ..
  Rat    10 VPR---PSYVFSADPI------ARPSEIN--FDGVKLDLSHEFS-------------------LV 44

  Fly    74 CATSAADSSNVETGPQVFLRLRPVKDASKAY------IVSEEANVLI---TSCKVDSTSNNVNRM 129
            .|...|:|...:...||.||:||...:.|.:      .|.:...||:   .|.....:..:..:|
  Rat    45 AANPGANSLESKNYLQVCLRIRPFTQSEKGHEAEGCVQVLDSQTVLLKDPQSILGHLSEKSSGQM 109

  Fly   130 EKHFGFTSIFDSTVGQRDIYDTCVGPKI---MEEECVTIMTYGTSGSGKTYTLLGDDVRAGIIPR 191
            .:.|.|:.:|.....|::.:..|:...:   ::.....|.|||.:.||||||..|.:...||:||
  Rat   110 AQKFSFSRVFGPETSQKEFFQGCIMQPVKDLLKGHSRLIFTYGLTNSGKTYTFQGTEENIGILPR 174

  Fly   192 ALENIFTIYQDTVFRSPKLKLIN-GSIVFLQDDASLKELQIRKKLLDLCPDISAHHQ-------R 248
            .|..:|...|:.::.....|... ...:.|..|...:|...:..||....:::.|:.       |
  Rat   175 TLNVLFDSLQERLYTKMSFKPHRCREYLQLSSDQEKEESANKNTLLRQIKEVTIHNDSYDILCGR 239

  Fly   249 LKQVIDGDHMFETKASTDVSVL--------VWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLK 305
            |...:......||..:.:.|.|        |||||.|||||.:|||..  |...||.:  ||.|:
  Rat   240 LTNSLTIPEFEETMNNCEQSSLNVDNIKYSVWVSFFEIYNESIYDLFV--PVSSKLQK--RKMLR 300

  Fly   306 IVGN-KGHVFIKGLTSVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSG 369
            :..: ||:.|||.|..:.|:.|:||.|||:||.:..:.|.|.:|..|||||.:||:.||:...|.
  Rat   301 LSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGVKHQSVAFTKLNNASSRSHSIFTIRILQIEDSE 365

  Fly   370 I---TTQSSYKFCDLAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPY 431
            |   |..|....||||||||...|.:.|.||:||.||||||:.||:|:.......|.|....:|:
  Rat   366 IPRVTRVSELSLCDLAGSERSMKTQSEGERLREAGNINTSLLTLGKCISVLKNSDKSKIQQHVPF 430

  Fly   432 RDSKLTMLLQAALLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPV----------- 485
            |:||||...|:...||.|:.||:.::.....|:|.||||.|:::|:.:...:.:
  Rat   431 RESKLTHYFQSFFTGKGKICMIINISQCCSAYDETLNVLKFSTVAQKVYVPDTLSSSQEKSFGST 495

  Fly   486 ------------------IKQHRVSYCGFMEFSKMSTCEGGDYTKELED----ENVRLQLE---- 524
                              :|:..||:    |.|.....|..|..::||:    :|:..:|.
  Rat   496 KSLQDVSLGSNLDNKILNVKRKTVSW----ENSLEDVVENEDLVEDLEENEETQNMETELTDEDS 556

  Fly   525 ----------------------IEQLK---YDHVLQMQLLEEKLRRELT-----------ATYQE 553
                                  ||.||   .:...:...||.|:|.|:|           |.::|
  Rat   557 DKPLEEGGVCAGHGKNKKLLDLIENLKKRLINEKKEKLTLEFKIREEVTQEFTQYWSQREADFKE 621

  Fly   554 IIQNNKKQYEDECEKKLLI----------AQRESEFMLSSQRRRYEEQ-----IEDLKDEIEELK 603
            .:.:.::..|:..|::|.|          :|.|......:.....||.     :||:.|.:|:
  Rat   622 TLLHEREILEENAERRLAIFKDLVGKPGESQDEPASRFCTMELETEESHNYVGVEDIFDSLED-- 684

  Fly   604 NPASDTDISD----------------DPNESKSPIEI 624
                  |::|                ||.|:.:.:::
  Rat   685 ------DVTDIKKQAELAHLYITSLVDPQEAIACLQL 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_611260.1	KISc	89..477	CDD:276812	142/419 (34%)
		GBP_C	<512..603	CDD:293879	28/149 (19%)
		coiled coil	576..586	CDD:293879	1/9 (11%)
		coiled coil	592..603	CDD:293879	4/10 (40%)
Kif20b	XP_006231343.1	KISc_KIF23_like	58..476	CDD:276819	142/421 (34%)
		RBD_KIF20B	599..647	CDD:409644	10/47 (21%)
		SMC_prok_B	675..1490	CDD:274008	9/49 (18%)