DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sub and klp9

DIOPT Version :9

Sequence 1:	NP_001286548.1	Gene:	sub / 44870	FlyBaseID:	FBgn0003545	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001342762.1	Gene:	klp9 / 2539778	PomBaseID:	SPBC15D4.01c	Length:	633	Species:	Schizosaccharomyces pombe

Alignment Length:	604	Identity:	169/604 - (27%)
Similarity:	283/604 - (46%)	Gaps:	110/604 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 QVFLRLR---PVKDASKAY---IVSEEANVLITSCKVDSTSNNVNR---MEKHFGFTSIFDSTVG 144
            |:|||::   |..|||..|   .|..:..:|:.|.: ||.:..|::   :|| ..||.:|..:..
pombe     3 QIFLRVKKAQPSSDASNKYGFLTVLNDYEILLESPE-DSHAYRVSKSKTLEK-ASFTKVFPPSCT 65

  Fly   145 QRDIYDTCVGPKIMEE----ECVTIMTYGTSGSGKTYTLLGDDVRAGIIPRALENIFTIYQ---- 201
            |.|::.|...|.|.:.    ....:.|.|.||:||||||.|...|.|:...||:.:|...:
pombe    66 QLDVFSTICAPLIADSLVNMNDTLLFTLGVSGAGKTYTLFGPSDRPGVAFLALDALFYAIKGREA 130

  Fly   202 --DTV--FRS--PKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFE 260
              .||  .||  .|.|::..| .||:.:|.| ::::        |:...:.....::.:.::.:
pombe   131 SPQTVEFLRSQLEKCKIVEAS-KFLRGEAPL-DIKV--------PNTEYYASHFPKIEEKNYQY- 184

  Fly   261 TKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKGHVFIKGLTSVFVTS 325
                     .:::||.||||:.::|||   .|....|.....:||.........|.|:..|||::
pombe   185 ---------AIYLSFAEIYNDRIFDLL---EKASFFGHRHALSLKKSSTSDKKSIAGIQKVFVSN 237

  Fly   326 SEEALRLLRLGQQRSTYASTSVNANSSRSHCVFTVDILKYNRSGITTQSSYKFC-----DLAGSE 385
            :.||.:|::...|.....||..|:.|||||.:.::::.|.    .|..:.::.|     ||||||
pombe   238 TTEAYKLIQKVLQLRKSTSTKSNSVSSRSHLIMSIELFKV----CTKSNKFESCQIDLVDLAGSE 298

  Fly   386 RVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLL--QAALLGKE 448
            |..:..||||.|:|..:||.||:.||:||:|.....:.|. .|||:|.||||.||  ...|.|..
pombe   299 RTRSAETSGLLLREGASINRSLLTLGQCLEALRRKHEGKQ-HIIPFRQSKLTELLFHSGHLSGLA 362

  Fly   449 KLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHRVSYC---GFMEFSK--MSTCEGG 508
            .:.|:|.:.|... ::||..|:.:::.|:.|:  .|.:.::..|..   ..::.||  .||....
pombe   363 GINMLVNIDPFGS-FDENAQVMRYSANAREIL--PPPLNENSGSQSPSHSLLQKSKNTSSTKALT 424

  Fly   509 DYTKELEDENVRLQL-------EIEQLKYDHVLQM-QLLEEKL----RRELTATYQEIIQN---- 557
            .:.::|:.||.:|::       |:..|:|:...|| :.:||::    |..||...:|..|.
pombe   425 SHLEQLQQENQQLRMLLADADSEMMNLEYEIRQQMTREMEERVSEVERTFLTKLLEESAQGIEYT 489

  Fly   558 ----------NKKQYEDECEKKLLIAQRESEFMLSSQRRRYEEQIEDLKDEIEELKNPASDTDIS 612
                      .||..::..||...|||             .|:.||:|.:|:..|:..:.....:
pombe   490 DQKLEKMGGWMKKLQDENSEKTETIAQ-------------LEQIIEELHEELRSLEEESIKESSA 541

  Fly   613 DDPNES---KSPIEILDDD 628
            ...||:   :|..::|.:|
pombe   542 TQQNENQHKRSSRKLLYED 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_001286548.1	KISc	89..477	CDD:276812	127/417 (30%)
		Kinesin	93..479	CDD:278646	125/415 (30%)
		GBP_C	<512..603	CDD:303769	28/116 (24%)
		coiled coil	576..586	CDD:293879	0/9 (0%)
		coiled coil	592..603	CDD:293879	4/10 (40%)
klp9	NP_001342762.1	KIP1	40..633	CDD:227392	156/566 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I1254
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47185
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	6.050