Protein Alignment sub and klp-6

DIOPT Version :10

• Sequence 1: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_498069.1
• Gene: klp-6 / 175683
• WormBaseID: WBGene00002218
• Length: 928
• Species: Caenorhabditis elegans
• Alignment Length: 577
• Identity: 154/577 - (26%)
• Similarity: 242/577 - (41%)
• Gaps: 138/577 - (23%)

  Fly    90 VFLRLRPVKDASKA-------YIVSEEANVLITSCKVDSTSNNVNRME------KHFGFT----S 137
            |.:|:||..|..|.       .:..||..|:     .|..:|:..|..      .|.||:    .
 Worm     9 VAVRVRPFNDREKTRNCKLVIEMPDEETTVI-----RDPKTNDEKRFTYDHSYWSHDGFSEKKNG 68

  Fly   138 IFDST----VGQRDIYDTCVGPKIMEE-----ECVTIMTYGTSGSGKTYTLLGDDVRAGIIPRAL 193
            ..:.|    ..||.:::. :|..::..     .| ::..||.:||||:|:::|.....||:|...
 Worm    69 YLEPTDPHYADQRRVFED-LGRGVLANAWAGYNC-SLFAYGQTGSGKSYSIVGFKNNKGIVPIVC 131

  Fly   194 ENIFTIYQDTVFRSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDG--- 255
            |.:|                                                    ||:.|.
 Worm   132 EELF----------------------------------------------------KQIADNKKK 144

  Fly   256 DHMFETKASTDVSVLVWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGN-KGHVFIKGLT 319
            :..||          |:||.:|||.|.|.|||:..|.       |:..||:..: |...:::.||
 Worm   145 NMQFE----------VFVSMMEIYCEKVRDLLSSTPP-------PKGGLKVREHPKNGFYVENLT 192

  Fly   320 SVFVTSSEEALRLLRLGQQRSTYASTSVNANSSRSHCV--FTVDILKYNRSGITT--QSSYKFCD 380
            :|.|.|.:|....:..|.:..|.|:|.:||.|||:|.:  .|.:.....::|.|:  :|.....|
 Worm   193 TVPVNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITFNQKSSKQAGGTSMKKSEINLVD 257

  Fly   381 LAGSERVNNTGTSGLRLKEAKNINTSLMVLGRCLDAASTVQKKKNA--DIIPYRDSKLTMLLQAA 443
            ||||||.:..||.|.||||...||.||..|||.:.|....||.|:.  ..||||||.||.||:.|
 Worm   258 LAGSERQSAAGTEGDRLKEGIVINQSLTTLGRVIKALHDSQKAKSGKKTQIPYRDSVLTCLLKNA 322

  Fly   444 LLGKEKLAMIVTVTPLDKYYEENLNVLNFASIAKNIIFKEPVIKQHRVSYCGFMEFSKMSTCEGG 508
            |.|..|..||..::|.|..:||.|:.|.||..||: |....|:.:::....
 Worm   323 LGGNSKTIMIAAISPADINFEETLSTLRFADRAKS-IKTNAVVNENQTERA-------------- 372

  Fly   509 DYTKELEDENVRLQLEIEQLKYDHVLQMQLLEEKLRRELTATYQEIIQNNKKQYEDECEKKLLIA 573
              .:||.:||:|||.:|:..........::  |||||:|....:|:.:..|...:...|:....|
 Worm   373 --LRELREENLRLQSQIQGGTAGDASNEEI--EKLRRQLAENQKEMEEMEKSWQQKIAEEAAKHA 433

  Fly   574 QRESEFMLSSQRRRYEEQIEDLKDEIEELKN------PASDTDISDDPNESKSPIEI 624
            ...||.:....:::....:.:|.:: ..|.|      |..::.:.:.|..|.:.|::
 Worm   434 SGASEKVEMEAKKKKMCHLWNLNED-PALTNVIVHFIPVGESVVGNKPTSSGNFIQM 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sub	NP_611260.1	KISc	89..477	CDD:276812	123/422 (29%)
		GBP_C	<512..603	CDD:293879	21/90 (23%)
		coiled coil	576..586	CDD:293879	2/9 (22%)
		coiled coil	592..603	CDD:293879	1/10 (10%)
klp-6	NP_498069.1	KISc_KIF1A_KIF1B	5..365	CDD:276816	127/432 (29%)
		tolA	<366..>446	CDD:236545	20/97 (21%)
		FHA_KIF28P	450..552	CDD:438761	7/41 (17%)
		KIF1B	659..699	CDD:463574