DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and Magi3

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001152826.1	Gene:	Magi3 / 99470	MGIID:	1923484	Length:	1476	Species:	Mus musculus

Alignment Length:	1130	Identity:	211/1130 - (18%)
Similarity:	348/1130 - (30%)	Gaps:	408/1130 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   836 NQKQQNKLEQIENYENCLQSERNEQHEQQFEQQKQHQATTAMAATQVAQQQTPSHKLQATLSSDP 900
            |||.|        :||.::..:   .::|..|.:.|.|.|.:.              :|..:.||
Mouse   365 NQKTQ--------FENPVEEAK---RKKQLGQAEIHSAKTDVE--------------RAHFTRDP 404

  Fly   901 NGNSNSNNNSHIVGISSSSSSNNSSI-----------TDDFLCVVDGLYQGRKDTASPSSSAFDE 954
                     |.:.|:...:|...|::           .|:||.|.:.|..|  ..|.....|..:
Mouse   405 ---------SQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDG--PAAQDGKIAPGD 458

  Fly   955 VMSKHTLDSFGSIAYRHLH----QQHQATSNGNSSSNTSNTNSNTNSN----------------- 998
            |:    :|..|:....|.|    |..|...          .|...|..
Mouse   459 VI----VDINGNCVLGHTHADVVQMFQLVP----------VNQYVNLTLCRGYPLPDDSEDPVVD 509

  Fly   999 -------TNSNSNTNGNTSNNTAVSTKTATVTKTGVSSSNSNSNSLNSSNSSMHTSSSSSGHSSN 1056
                   .|..|.|.|.|..||......|.|.     ..|..|..:.:|: .::..|.||...::
Mouse   510 IVAATPVINGQSLTKGETCMNTQDFKLGAMVL-----DQNGKSGQILASD-RLNGPSESSEQRAS 568

  Fly  1057 IASATSSSSATSSSTVP---------DDLSLAPPGYEVSQ--------------------QQQQQ 1092
            :||  |.||.....|:|         ..::.:|.|.:|..                    .|..|
Mouse   569 LAS--SGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQ 631

  Fly  1093 HLVATPVTMLLPPMAKHRELPV--DVPDSFIEMVKTTPRYPPPAHLSSRGSLLSNGSASTAHTTL 1155
            :|....|..:|      ::.||  |||   :.:::..|..|.....:...:..::||..|.:..:
Mouse   632 NLTHLQVVEVL------KQFPVGADVP---LLILRGGPCSPTKTAKTKTDTKENSGSLETINEPI 687

  Fly  1156 SSMGVAPSPVTATAAAAASASAACATTAVAAAAVSGVAD-----------------GDARRVADE 1203
                  |.|:....:...|.|.....:.|...:.:...|                 |...||
Mouse   688 ------PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRV--- 743

  Fly  1204 LNGNAKPVPPPRDHLRV---------EKDGRLVNCSPAPQLPDRRAPGNASSGSSGATTHPLQHQ 1259
            |.|:.     |...:.:         ||||||   ..|.:|  ....|....|.|        |:
Mouse   744 LGGDG-----PDQSIYIGAIIPLGAAEKDGRL---RAADEL--MCIDGIPVKGKS--------HK 790

  Fly  1260 QIAQIVEPTLEQ---LDSIKK---YQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATP 1318
            |:..::......   |.::::   |.|  ::..:|..:...||        ||.:|...:   .|
Mouse   791 QVLDLMTTAARNGHVLLTVRRKIFYGE--KQPEDESHQAFSQN--------GSPRLNRAE---LP 842

  Fly  1319 GKAVAQQQQQATLATQVVGVENEAY----LPDEDQPQ--------AEQIDGYGELIAALTRLQNQ 1371
            .::..|:....||..:    |||.:    |..:.:|.        ...|||            :.
Mouse   843 TRSAPQEAYDVTLQRK----ENEGFGFVILTSKSKPPPGVIPHKIGRVIDG------------SP 891

  Fly  1372 LSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKD-IVELLTQ 1435
            ..:.|...:...:||                           |:|   .|.:.|..| ||:|:..
Mouse   892 ADRCGGLKVGDHISA---------------------------VNG---QSIVDLSHDNIVQLIKD 926

  Fly  1436 SNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNL 1500
            :.....:             .::|.:.  :|  |.||           .|.|...||....:
Mouse   927 AGVTVTL-------------TVVAEEE--HH--GPPS-----------GTNSARQSPALQHR--- 960

  Fly  1501 GMVVPPPVVPPPLAQRGAMPLP------RGESPPPV--------------PMPPLATMPMSMPVN 1545
                       |:.|..|..:|      .||....|              ..|..|.:
Mouse   961 -----------PMGQAQANHIPGDRIALEGEIGRDVCSSYRHSWSDHKHLAQPDTAVI------- 1007

  Fly  1546 LPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGE---AVVIGRIVRGGAAEKSGLLHEGDE 1607
                :..|:.::|:.....:::|:.....|.::|...|   .:.|.|:...|.|.|.|.:|.||:
Mouse  1008 ----SVVGSRHNQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQ 1068

  Fly  1608 ILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVP------------AGSPPSVGVMGGTTGSQLA 1660
            |:|:||:..:|.|......|:.|....:..|:.|            ..||.|..|:
Mouse  1069 IVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDTNSPSSSNVI--------- 1124

  Fly  1661 GLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDP-NWWQAYREGEE-- 1722
                             :|..|..   :|......:|::.   ||.:.||. ...|...:.||
Mouse  1125 -----------------YDEQPPP---LPSSHSASTFEES---HVPATEDSLTRVQICEKAEELK 1166

  Fly  1723 ------DQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDG--SGSKGATLLCARKGR--KK 1777
                  ..||.|..|...:|...:||.   .::.......|:..  .|..|.|    |:||  ..
Mouse  1167 DTVQEKKSTLNGSQPEMKYQSVHKTMS---KKDPPRGSGHGEKSRLKGENGVT----RRGRSASP 1224

  Fly  1778 KKKASSEAGYPLYATTAPDETDPEE 1802
            ||..:..:...|.....|.::||:|
Mouse  1225 KKSVNRHSEEHLEKIPRPLKSDPKE 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	6/43 (14%)
		PDZ_signaling	1562..1640	CDD:238492	22/80 (28%)
		SH3_MPP5	1673..1734	CDD:212969	15/69 (22%)
		Guanylate_kin	1820..1994	CDD:279019
		GuKc	1831..2002	CDD:214504
Magi3	NP_001152826.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:15652357	18..108
		PDZ_signaling	24..103	CDD:238492
		NK	125..>199	CDD:302627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266
		WW	297..329	CDD:197736
		WW	345..375	CDD:238122	6/17 (35%)
		Interaction with PTEN. /evidence=ECO:0000250	413..495		19/97 (20%)
		PDZ	416..496	CDD:214570	18/95 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..575		7/26 (27%)
		PDZ	578..659	CDD:214570	15/89 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..691		4/32 (13%)
		PDZ	729..812	CDD:214570	20/103 (19%)
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811		20/102 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..844		7/36 (19%)
		PDZ_signaling	851..936	CDD:238492	21/143 (15%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939		22/145 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..966		10/55 (18%)
		PDZ_signaling	1023..1101	CDD:238492	22/77 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1151		10/73 (14%)
		MIP-T3	<1166..>1431	CDD:287245	21/91 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1476		21/89 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900