DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and CARD11

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001311210.1	Gene:	CARD11 / 84433	HGNCID:	16393	Length:	1154	Species:	Homo sapiens

Alignment Length:	998	Identity:	191/998 - (19%)
Similarity:	309/998 - (30%)	Gaps:	325/998 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1256 LQHQQIAQIVEPTLEQLDSIK--------KYQEQLRRRREEEERIAQQNEFLRNSLR-GSRKL-- 1309
            |:|:......|..||:..|:|        ..:||:.....|.|.:..:|:.|::.:: |.|.|
Human   232 LKHRLNKMEEECKLERNQSLKLKNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPD 296

  Fly  1310 --KALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQI-DGYGELIAALTRLQNQ 1371
              ||:.|.....:..|.:.:|..:        |..|...|:..|||:: |.|.|
Human   297 SDKAILDILEHDRKEALEDRQELV--------NRIYNLQEEARQAEELRDKYLE----------- 342

  Fly  1372 LSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQ-----RRR-----SRVSGPLHHSSLGLQ 1426
             .|..|....       |.|......:.....|.:||     |.|     ||......:|...::
Human   343 -EKEDLELKC-------STLGKDCEMYKHRMNTVMLQLEEVERERDQAFHSRDEAQTQYSQCLIE 399

  Fly  1427 KD----IVELLTQSNTAAAIELGNLLTSHE-----MEGLLLAHDRIANHTD-------------- 1468
            ||    .:..|.:.|....||    :...|     :|..|....:.:|:.|
Human   400 KDKYRKQIRELEEKNDEMRIE----MVRREACIVNLESKLRRLSKDSNNLDQSLPRNLPVTIISQ 460

  Fly  1469 --GTPSPTPTPTPAIGAATG------STLSSPVAGPKRNL---GMVVPPPVVPPPLAQRGAMPL- 1521
              |..||......|..::|.      |....|...|:|.:   |:.:          ||...|:
Human   461 DFGDASPRTNGQEADDSSTSEESPEDSKYFLPYHPPQRRMNLKGIQL----------QRAKSPIS 515

  Fly  1522 --------PRGE-------SPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKST 1571
                    .:|.       ||......|:......|......|:......:...|..|::..|..
Human   516 LKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQPPRSRSSIMSITAEPPGNDSIVRRYKED 580

  Fly  1572 EPLGATVRNEGEAVVIGRIVRGG-------------------AAEKSGLLHEGD-----EILEVN 1612
            .|..:||..:.::        ||                   :...|...|:.:     ::.:||
Human   581 APHRSTVEEDNDS--------GGFDALDLDDDSHERYSFGPSSIHSSSSSHQSEGLDAYDLEQVN 637

  Fly  1613 -------------------------GQELRGKTVN------EVCALLGAMQGTLTFLIVPAGSPP 1646
                                     |..::..|:|      ::..|.|..:|:....:.|.....
Human   638 LMFRKFSLERPFRPSVTSVGHVRGPGPSVQHTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAE 702

  Fly  1647 SVGVMGGTTGSQLAGLGGAHR--------DT----------------AVLHVRA-HFDY-----D 1681
            ..|:   ..|.||..|.|..|        ||                ..||.:. |..|     |
Human   703 KAGL---REGHQLLLLEGCIRGERQSVPLDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKD 764

  Fly  1682 PEDDL-------YIPCRELGISFQK---------GDVLHV---ISREDPNWWQAYREGEEDQTL- 1726
            .||.|       ||.. .|.||.|.         .||:||   :.::...|..|..:...|..|
Human   765 MEDGLITSGDSFYIRL-NLNISSQLDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLD 828

  Fly  1727 AGLIPSQSFQHQRETMKL------------------------AIAEEAGLARSRGKDGSGSKGAT 1767
            .|.|||.|...|...:||                        .:..|..|:.|..:.......|:
Human   829 MGTIPSYSRAQQLLLVKLQRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRAS 893

  Fly  1768 LL-------CARKGRKKKKKASSE-----AGYPL------------YATTAPDETDPE------- 1801
            .|       .:|...|.|:..|:|     :|.||            ..|...:|.|||
Human   894 FLFGQLLQFVSRSENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNL 958

  Fly  1802 EILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMADSERFSAAVPHTSRARREGEVPGVD 1866
            .::.|..|..:|  ...:||::.  .|.:....|.|||:.........:..:....|:
Human   959 SLIPYSLVRAFY--CERRRPVLF--TPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRD------- 1012

  Fly  1867 YHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKP 1931
             .|:.||..|..|.:|.     :...|:...:...|..|.|..|.|:|.......:.|..|::.|
Human  1013 -EFLRRQKTETIIYSRE-----KNPNAFECIAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYP 1071

  Fly  1932 YVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDMEA-----------RWGHLFDMIIINN 1985
            .|:.:.....:..|.:||......:||.|:......:::||           .||.:.:::.:..
Human  1072 IVLFIRVCEKNIKRFRKLLPRPETEEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVK 1136

  Fly  1986 DTERAYHQLLAEINSLEREPQWV 2008
            |          :|...:|:..||
Human  1137 D----------KIGEEQRKTIWV 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	9/51 (18%)
		PDZ_signaling	1562..1640	CDD:238492	17/132 (13%)
		SH3_MPP5	1673..1734	CDD:212969	25/86 (29%)
		Guanylate_kin	1820..1994	CDD:279019	36/184 (20%)
		GuKc	1831..2002	CDD:214504	34/181 (19%)
CARD11	NP_001311210.1	CARD_CARD11_CARMA1	22..107	CDD:260070
		Linker. /evidence=ECO:0000305\|PubMed:31296852	111..128
		BAR	<173..>257	CDD:299863	7/24 (29%)
		GBP_C	<252..418	CDD:303769	40/192 (21%)
		coiled coil	387..398	CDD:293879	1/10 (10%)
		coiled coil	407..418	CDD:293879	2/10 (20%)
		Inhibitory domain (ID). /evidence=ECO:0000303\|PubMed:31296852	450..666		32/233 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..626		29/183 (16%)
		PDZ_signaling	680..752	CDD:238492	15/74 (20%)
		SH3	777..839	CDD:302595	19/62 (31%)
		NK	<1009..1143	CDD:302627	30/156 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810