DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and CARD14

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001353314.1	Gene:	CARD14 / 79092	HGNCID:	16446	Length:	1004	Species:	Homo sapiens

Alignment Length:	824	Identity:	167/824 - (20%)
Similarity:	284/824 - (34%)	Gaps:	226/824 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1263 QIVEPTLEQLDSIKKYQEQLRRRREEEERIAQ------QNEFLRNSL---RGSR-----KLKALQ 1313
            ::.|.:|......:...|:|.|.:||.|::..      :.:.|..||   ||||     ::.:|:
Human   245 ELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLR 309

  Fly  1314 DTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLS 1378
            :     :|||.::|:            |.|..:::|                |.||.|.||....
Human   310 E-----RAVAAERQR------------EQYWEEKEQ----------------TLLQFQKSKMACQ 341

  Fly  1379 TLAGRVSAAHSVLASASVAHVLAARTAVLQRRR-----SRVSGPLHHSSLGLQKD---------- 1428
            ....:|:|             |.|:...||:.|     :|.|.....|...::||
Human   342 LYREKVNA-------------LQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELT 393

  Fly  1429 --IVELLTQSNTAAAIELGNLLTS--------HEMEGLLLAHDRIANHTD---GTPSPTPTPTPA 1480
              :.||.||.....|...|.|...        .|.:.|:..| .|....|   ...|.|.:...:
Human   394 DQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMH-AICPRDDSDCSLVSSTESQLLS 457

  Fly  1481 IGAATGS-------TLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMP----- 1533
            ..:||.|       ..|||....:::|...|.......|.:....:.:|.|:   |..:|
Human   458 DLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGD---PGALPGAKAG 519

  Fly  1534 -PLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPL--GATVRNEGEAVVIGRIVRGGA 1595
             |.....:....:||                  |:|.|.:|:  |....:|...::..|..|...
Human   520 DPHLDYELLDTADLP------------------QLESSLQPVSPGRLDVSESGVLMRRRPARRIL 566

  Fly  1596 AEKSGLLHEGDEILE---VNGQELRGKTVNEVCALLGAMQ-----GTLTFLI-VPAGSPPSVGVM 1651
            ::.:.|..:||.:||   |.|..|.|..::.|.....|.|     ||...:: ..|..|....|:
Human   567 SQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVL 631

  Fly  1652 GGTTGSQLAGL----------------GGAHR-------------DTAVLHVRAHFDYDPEDDLY 1687
            ..||..:..||                .|..|             |:..:.|....:...:.:|.
Human   632 EDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQ 696

  Fly  1688 IPCRELGISFQKGDVLHVISR--EDPNWWQAYREGE---EDQTLAGLIPSQSFQHQRETMKLA-- 1745
            :.|.|         ||||...  :....|.|:|...   :|....|.||:.| :.|::.:.|.
Human   697 VHCNE---------VLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYS-RAQQQLIALIQD 751

  Fly  1746 IAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDP---------- 1800
            :.::..:.|      ..|.|......|.....|.|||     ||..:....:.||
Human   752 MTQQCTVTR------KPSSGGPQKLVRIVSMDKAKAS-----PLRLSFDRGQLDPSRMEGSSTCF 805

  Fly  1801 --EEILTYEEVALYYP-RATHKRPIVLIGPPNIGRHELRQRLMADSERFSAAVPHTSRARREGEV 1862
              |..||.....|..| |....||::|: |..:|: .|.::|.. .:.|...:.
Human   806 WAESCLTLVPYTLVRPHRPARPRPVLLV-PRAVGK-ILSEKLCL-LQGFKKCLA----------- 856

  Fly  1863 PGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRAS 1927
                 .:::::.:||.......::.||........:..|:.:::......:|::...|:..|...
Human   857 -----EYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRM 916

  Fly  1928 DLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDME 1971
            |:.|.|:.|   |:::...|||:.|........:.::..||..|
Human   917 DIFPIVIHV---SVNEKMAKKLKKGLQRLGTSEEQLLEAARQEE 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/62 (21%)
		PDZ_signaling	1562..1640	CDD:238492	22/88 (25%)
		SH3_MPP5	1673..1734	CDD:212969	15/65 (23%)
		Guanylate_kin	1820..1994	CDD:279019	28/152 (18%)
		GuKc	1831..2002	CDD:214504	24/141 (17%)
CARD14	NP_001353314.1	CARD_CARD14_CARMA2	19..104	CDD:260068
		SMC_N	<151..448	CDD:330553	53/249 (21%)
		Maintains the protein in an inactive state. /evidence=ECO:0000269\|PubMed:27071417	409..568		33/180 (18%)
		PDZ_signaling	583..655	CDD:238492	16/71 (23%)
		SH3	680..742	CDD:327375	16/71 (23%)
		NK	<858..961	CDD:327404	20/103 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910