DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdt and dlg5

DIOPT Version :9

Sequence 1:NP_001033835.2 Gene:sdt / 44861 FlyBaseID:FBgn0261873 Length:2020 Species:Drosophila melanogaster
Sequence 2:XP_004916076.1 Gene:dlg5 / 779611 XenbaseID:XB-GENE-978275 Length:1971 Species:Xenopus tropicalis


Alignment Length:2219 Identity:385/2219 - (17%)
Similarity:666/2219 - (30%) Gaps:808/2219 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 ASSLQHLAEEVDNEDLDDDDDVDGANYCG--------------------------------ITYI 359
            |..|.::.||.....:.|.:::||::..|                                :..|
 Frog    23 ADRLLNVLEEAGALTIRDREELDGSSSSGQEKVDLLLKMLLVKEKDHFQDLRVALEKTEPHLLSI 87

  Fly   360 SYNNKHAQLPT--------TTLPATTALPAAAASLATTAAIYQQRQQQQHQQQQQQQQQPVHHHN 416
            .|.|......|        ||:|:.:....:.:|:.||                .:...|     
 Frog    88 LYLNGLGTGDTAGSTYSVLTTMPSDSESSGSLSSIGTT----------------NKPSSP----- 131

  Fly   417 HPPTA--------------SQLNRATAPAP-----LQLGGP------------VNPSF----VDA 446
             ||||              |||.:.|....     |.|..|            :.|.:    |..
 Frog   132 -PPTAADSLQVNEKIETILSQLRQVTRERDELRKRLALSSPGSTFDDCRSSPKLTPDYERLKVQC 195

  Fly   447 QTSTSPLMAQQLHSQHAD-VDAAPPSSSSSSAVVVVERHVHGTTTPKTEYSTAI--SSGQLQQAF 508
            ..:.|.|.|  |.||||. :.....::..:.....:...:....|...|.|.::  :..|||:.|
 Frog   196 MKAMSELEA--LQSQHAKALKKCEEAAKEADFYHALHSRMLSDHTQLQEDSESMRRNHAQLQREF 258

  Fly   509 AELQ--------LHSSN--NNATQQQQQHLLLSNNNNSNNSMAAAQTTASLMKNCDLLISNNLYP 563
            :.||        ||.::  ..:..::||.|::..|.:|.                   :.|.||.
 Frog   259 SHLQQSCQDLKHLHETDQLEMSELRRQQQLVVKQNGSSE-------------------LINKLYN 304

  Fly   564 PRRELLE------DVIVHQASD-VHSYSTSASAAAIASSSNRSQQQQ-----QQQQ-----QHQL 611
            ...:.||      |.:..|.:: |.|::........:....||.|:|     :|::     |||.
 Frog   305 TALDKLEGVKKDYDSLRRQYNEKVSSHNLDLGRLEQSEEEKRSLQKQLEGLLKQRENAIHFQHQF 369

  Fly   612 LSA--AYELQQQQ--QLQLQQQQQQQNSPTSSISIGRTELLLGDQSLRQDPRGNRRRSGSSIVVL 672
            .|:  .|:..||:  ::.||.::.|:..........|.:.:....|...:.....|         
 Frog   370 SSSMRRYDSIQQELNKVTLQNKELQREMERLQAEATRFKTMQLKASKEAEKYKEER--------- 425

  Fly   673 DGDDLKPCLPDDYISGQHHL---NHQQQLQLQQQLQQQHPLQQQHYRTHSGDIREIDQEM----- 729
                       |.:..::.|   ...|.::...::|.:..|.|...:..|.:.|...:||     
 Frog   426 -----------DSVFNEYRLIMSERDQVIKEMDKMQTELELAQGRLKNTSSEKRVASEEMEALRQ 479

  Fly   730 -LTMLSVNQDNGPHREMAVDCPDTFIARNKTPPRY----PPPRPPQKH-----------KKSTNT 778
             |....|.:|.            :...||:...:|    ......||.           |:..:.
 Frog   480 ELNSALVERDR------------SIFERNELLEKYCHEVKDKAEAQKELDQACKDIETVKEERDV 532

  Fly   779 TTTTTITALTNNDHANKMLIVAYHSSHQ---------------HEQLQQQ-----HPSKTSTTTT 823
            .......|:...||    |:..|:.:.|               .|.|::|     |..|.:|...
 Frog   533 ARKERTEAIIQRDH----LLREYYQARQIQDSATLDMERANKEIEVLRKQYEAMSHELKEATQEA 593

  Fly   824 TIA---LDVATQ-----------------NLYNQKQQNKLEQIENYENC--LQSERNE------- 859
            .:|   .|.|.|                 ||..::.:...|..|...|.  ::.::|:       
 Frog   594 EVAKCRRDWAFQERDKIVAERESIRTLCDNLRRERDRAVSELAEALRNLDDMRKQKNDASRELKE 658

  Fly   860 ---------QHEQQFEQQKQHQATTAMAATQVAQQQTPSHKLQ--------ATLSSDPNGNSN-- 905
                     :.|.:|.|...|.:..:...|...:.:|...:.:        ..|..|.....|  
 Frog   659 LKEKMDNQMEKEARFRQLMAHSSHDSAIDTDSLEWETEVVEFERDREDMDLKALGFDVADGVNEP 723

  Fly   906 ---SNNNSHIVGISSSSSSNNSSITDDFLCVVDGLYQGRKDTASPSSSAFD--EVMSK--HTLDS 963
               ..:...:..:...|.::.....:|.|..::.:....||......:...  ||::.  ....|
 Frog   724 LFPGESCIFVTKVDKGSIADGRLRVNDCLLKINDVDLANKDRKQLLKAVLSGGEVINMVIRRRKS 788

  Fly   964 FGS--IAYRHLHQQHQ----------------------------------ATSNGNSSSNTS--- 989
            .|:  |...|:|...|                                  .|.||.|..|.|   
 Frog   789 LGNRIITPLHIHLGSQKDSGISLESGVLVSAVVPGSPAAKEGSLVAGDRVVTINGISLDNKSVME 853

  Fly   990 --------------------------------------------NTNSNTNSNTNSNSNTNGNTS 1010
                                                        |.::....|..:||:|..:..
 Frog   854 CEALLRNCQESLNLSLLKVVPPNTSWSGQNLFENLKESCHVLSPNIHAQNKRNLKNNSSTQTDIF 918

  Fly  1011 NNTAVSTKTATVTKTG------VSSSNSNSNSLNSSNSSMHTSS-----SSSGHSSNIASATSSS 1064
            |...:..|.....:||      :|..:.:.:||:|....:....     ...||....|.....:
 Frog   919 NPDILECKKNMGDRTGSERALQLSCHSHSEHSLSSLGGEVFMGQGYDILDDGGHPLGFADTMEDN 983

  Fly  1065 ---SAT---SSSTVPDDLSLAPPGYEVSQQQQQQHLVATPVTMLLPPMAKHRELPVDVPD----- 1118
               :||   ||.|.|.  .:..||:...:           .|:...|  :||:...| ||     
 Frog   984 LVETATGKRSSGTWPK--VMVSPGHSQGE-----------FTVFKKP--RHRKSIFD-PDTFKRP 1032

  Fly  1119 ------SFIEMVKT---------TPRYPPPAHLSSRGSLL------SNGSASTAHTTLSSMGVAP 1162
                  ||:..|:.         |.|.|.|.....|...:      .:.|||.:..|..|...:|
 Frog  1033 QTPPKISFLPPVQVLGHSPQPSKTERPPTPPTPPKRSDSIKFKHRHQSSSASDSTVTAGSPPTSP 1097

  Fly  1163 SPVTATAAAAASA------SAACATTAVAAAAVSGVADGDA-----RRVADELNGNAKPVPPPRD 1216
            ||....|..:..|      .:.|....:.......:..||.     |....||. .|:|...|..
 Frog  1098 SPGPLPAETSHKAHHSRAIGSCCREDGIDCPLTGCIGTGDVEGCLQRAEEPELK-RARPRSAPAL 1161

  Fly  1217 HLRVEKDGRLVNCSPAPQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQ 1281
            ..|:           ||.|....|....|..|....:..|.|..|.  ..||             
 Frog  1162 RHRL-----------APVLIPHYALQKFSMNSEERLSPELAHDWIR--FSPT------------- 1200

  Fly  1282 LRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAY--- 1343
                     |..:.::....|:.|            ||.:....:..|........:.|..|   
 Frog  1201 ---------RSPRHSDIFAASMYG------------PGMSGTVPRSLAPCPAVTAVLRNPIYTAW 1244

  Fly  1344 ---LPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLA---GRVSAAHSVLASASVAHVLAA 1402
               :|..:.|.:                .||:.:..|.:.|   ||:|      ...|..|    
 Frog  1245 SHRVPSNNCPSS----------------ANQICQQHLHSSAQHHGRLS------LDLSNKH---- 1283

  Fly  1403 RTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHT 1467
            ........||||.    |.|             ::..::..||:..|           :||.   
 Frog  1284 PNEFCDTSRSRVP----HGS-------------NSLPSSARLGSSRT-----------ERIK--- 1317

  Fly  1468 DGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPL---------AQRGAMPLPR 1523
              .||....|..::|:..||...|..:.|.     :..||..|..|         :|.....|||
 Frog  1318 --IPSTPRYPRSSVGSDRGSLSHSECSSPS-----LASPPHSPLNLETSSFASSQSQSSVASLPR 1375

  Fly  1524 GESPPPVPM------PPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATV-RNE 1581
             .|...||:      .||...|                       |.::::|.:||||.:: ..|
 Frog  1376 -ISVSTVPIGERRKDRPLVEEP-----------------------RHVKVQKGSEPLGISIGGGE 1416

  Fly  1582 GEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLI------- 1639
            ...:.:.::..|..|:::||.: ||::||.||..||..|..:...::|....|:|.|.       
 Frog  1417 SGGIFVSKVTTGSIAQQAGLEY-GDQLLEFNGINLRNATEQQARLIIGQQCDTITILAQYNPNMC 1480

  Fly  1640 ------------------VPAGS-----------------------PPSVGVMGGTT-------- 1655
                              .|..|                       |||......|:        
 Frog  1481 QHIHSRSSSRLDTSTTHSTPHSSGAATPDNHSIIDTVSEQDEGTMTPPSKESTPSTSPCSSLRTN 1545

  Fly  1656 ----------------------GSQLAG----------------LGGAHRDTAVL---------- 1672
                                  |.|:.|                :||..:...||          
 Frog  1546 AEGIKRHSELRVVTLSKSPEKLGIQICGGNLHGIFVLDIEEENVVGGLLKGDMVLEYGSVDMRNR 1610

  Fly  1673 --------------------------------------HVRAHFDYDPEDDLYIPCRELGISFQK 1699
                                                  ::||.:|...|    :|..   :||:|
 Frog  1611 TAEEAYLEMLKPAENIKVKVQQKIDEFNKLKDLPGDGFYIRALYDRQAE----LPSE---LSFKK 1668

  Fly  1700 GDVLHV---ISREDPNWWQAYREGEEDQTL-AGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDG 1760
            .|:|:|   :.:.....|.|::..|..|.| .|.:||:....|..:.:|:::|        |:|.
 Frog  1669 DDILYVDDTLPQGTFGTWMAWQLDENAQKLQRGQVPSKYMMEQEFSRRLSMSE--------GRDE 1725

  Fly  1761 SGSKGATLLCARKG----RKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPR-----A 1816
            :.:.......||:.    :.|.|::.|..|..|..... ..||....|. |.|:|.|.|     .
 Frog  1726 TMASKTLSAAARRSFFRRKNKHKRSGSRDGKDLQGLDT-ISTDSIPFLD-ESVSLAYQRVQRVDC 1788

  Fly  1817 THKRPIVLIGPPNIGRHELRQRLMADSERFSAAVPHTSRARREGEVPG------VDYHFITRQAF 1875
            |..||::::||            :.|:.:....          .|.||      ::....::||.
 Frog  1789 TSPRPVLILGP------------LVDAVKDMLV----------KESPGKFCRCPLEVMKASQQAI 1831

  Fly  1876 EADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPS 1940
            |..:....|:::......:..|::.:|:.:......|:|::.|.:::.|.:..:.|.|:.:...|
 Frog  1832 ERGVKDCLFIDYKRRSGHFDVTTVASIKEITEKDCHCLLDIAPHAIERLHSVHIYPIVLFIRYKS 1896

  Fly  1941 LDKLRQKK----LRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSL 2001
            ..:::::|    ||  :...::..|:...||..:|..:...|..:|.........:|:.:.::..
 Frog  1897 TKQIKEQKDPIFLR--DKVTQKHSKEQFETAHKIEQEYSKYFTAVIQGGALFSICNQICSIVDQE 1959

  Fly  2002 EREPQWVPA 2010
            :.:..|:||
 Frog  1960 QSKALWIPA 1968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdtNP_001033835.2 PDZ_signaling <54..102 CDD:238492
L27 1423..1466 CDD:295425 5/42 (12%)
PDZ_signaling 1562..1640 CDD:238492 24/103 (23%)
SH3_MPP5 1673..1734 CDD:212969 19/64 (30%)
Guanylate_kin 1820..1994 CDD:279019 30/183 (16%)
GuKc 1831..2002 CDD:214504 27/180 (15%)
dlg5XP_004916076.1 CARD 9..88 CDD:260018 8/64 (13%)
Takusan 127..213 CDD:368141 22/93 (24%)
Smc <136..544 CDD:224117 80/460 (17%)
COG4372 443..>672 CDD:226809 39/244 (16%)
PDZ_signaling 697..784 CDD:238492 10/86 (12%)
PDZ_signaling 798..867 CDD:238492 9/68 (13%)
PDZ 1395..1477 CDD:214570 25/105 (24%)
dbPDZ_assoc 1475..1554 CDD:374667 6/78 (8%)
PDZ 1554..1633 CDD:214570 7/78 (9%)
SH3_DLG5 1649..1711 CDD:212794 19/68 (28%)
GuKc 1784..1960 CDD:214504 32/199 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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