DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Mpp7

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_011245327.1	Gene:	Mpp7 / 75739	MGIID:	1922989	Length:	601	Species:	Mus musculus

Alignment Length:	701	Identity:	217/701 - (30%)
Similarity:	350/701 - (49%)	Gaps:	154/701 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1357 GYGELIAAL-TRLQNQLSKSGLSTLAGRV---SAAHSVLASASVAHVLAARTAVLQRRRSRVSGP 1417
            |..||:||| .:||..:......|....|   .:.||::......|....:..:          |
Mouse    13 GLYELLAALPAQLQPHVDSQEDLTFLWDVFGEKSLHSLVKIHEKLHCYEKQNPL----------P 67

  Fly  1418 LHHSSLGLQKDIVELLTQSNTAAAI-ELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAI 1481
            :.|.:..|..|:.|.|......:.| ||..||:...::.||..||.:|..:
Mouse    68 ILHGAAALADDLTEELQNKLPNSEIRELLKLLSKPNVKALLSVHDTVAQKS-------------- 118

  Fly  1482 GAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNL 1546
                                   ..||:                  ||||
Mouse   119 -----------------------YDPVL------------------PPVP--------------- 127

  Fly  1547 PMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGE--AVVIGRIVRGGAAEKSGLLHEGDEIL 1609
                  ..::|:.|:::||::.|::||||||::.:.:  |:.:.||:|||||::|||:|.|||:.
Mouse   128 ------DDIDDEEDSVKIIRLVKNSEPLGATIKKDEQTGAITVARIMRGGAADRSGLIHVGDELR 186

  Fly  1610 EVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHV 1674
            ||||..:..|...|:..:|...:|.:||.|:|:....:....|                  .:.:
Mouse   187 EVNGIPVEDKRPEEIIKILSQSKGAITFKIIPSTKEETPSKEG------------------KIFI 233

  Fly  1675 RAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTLAGLIPSQSFQHQR 1739
            :|.|||||::|..|||:|.|:||:|||:|.::|::|..||||..||:.:.. ||||||:.||.:|
Mouse   234 KALFDYDPKEDKAIPCKEAGLSFRKGDILQIMSQDDVTWWQAKHEGDANPR-AGLIPSKHFQERR 297

  Fly  1740 ----------ETMKLA-------IAEEAGLARSRGKDGSGSKGATLLCA-----RKGRKKKKKAS 1782
                      :.:||:       ..|...:....|.||:.|  .|.:..     |..||.||...
Mouse   298 LALRRPEIVVQPLKLSNTKSYEETVECEEIKEDTGHDGNNS--GTYIAGFRRSFRLSRKNKKINK 360

  Fly  1783 SEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHK-RPIVLIGPPNIGRHELRQR-LMADSER 1845
            |     :|.....::.|..::.|||||..|..:...| |.|||:||..:|.:||::: ||:|::.
Mouse   361 S-----MYECKKSEQYDTADVPTYEEVTPYRRQIHDKYRLIVLVGPVGVGLNELKRKLLMSDAQH 420

  Fly  1846 FSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGK 1910
            :...||||:||||..|..||:|.||::..||.|:...:|:|:|||:..|||||::::|:|:|..|
Mouse   421 YGVIVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNK 485

  Fly  1911 ICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLR-----------NGEPFKEEELKDII 1964
            :|:|::.|.::|.||..:.||||:.:.|||:::||:.:..           ..:||.||:.:::|
Mouse   486 VCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGTAKPFTEEDFQEMI 550

  Fly  1965 ATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVHN 2015
            .:|:.||:::|||||.||||:|...|:::|....:.||.:..|||..|:|:
Mouse   551 KSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETDTHWVPVSWLHS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	14/43 (33%)
		PDZ_signaling	1562..1640	CDD:238492	34/79 (43%)
		SH3_MPP5	1673..1734	CDD:212969	32/60 (53%)
		Guanylate_kin	1820..1994	CDD:279019	77/185 (42%)
		GuKc	1831..2002	CDD:214504	72/182 (40%)
Mpp7	XP_011245327.1	L27	16..68	CDD:197794	12/61 (20%)
		L27	75..125	CDD:197794	16/104 (15%)
		PDZ_signaling	137..217	CDD:238492	34/79 (43%)
		SH3_MPP7	232..292	CDD:212966	32/60 (53%)
		GuKc	403..588	CDD:214504	72/184 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820