DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Lrguk

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_006506776.1	Gene:	Lrguk / 74354	MGIID:	1921604	Length:	1341	Species:	Mus musculus

Alignment Length:	202	Identity:	56/202 - (27%)
Similarity:	92/202 - (45%)	Gaps:	27/202 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1813 YPRATHKRPIVLIGPPNIGRHELRQRLMAD-SERFSAAVPHTSRARREGEVPGVDYHFITRQAFE 1876
            ||.      ::|.||...|:.||..||... |..|.....||:|....||...||||||:::.|:
Mouse   414 YPM------LILTGPAACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQEVFD 472

  Fly  1877 ADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSL 1941
            ..:...:|:....|....||.:.:.|..:...|....:::..:.::.|:.|..:|..:||.|...
Mouse   473 EMLNMGKFILTFNYGNHNYGLNRDTIEGIARDGLASCIHMELEGVRSLKYSYFEPRYILVVPMDK 537

  Fly  1942 DK----LRQKKLRNGEPFKEEELKDIIATAR-----DMEARWGHLFDMIIINNDTERAYHQLLAE 1997
            :|    ||:|.|     |...|::  ||.:|     .:..::...||.:|..:|.:.||.:|
Mouse   538 EKYEGYLRRKGL-----FSRAEIE--IAVSRVDLYVKVNQKYPGYFDAVINADDMDIAYQKL--- 592

  Fly  1998 INSLERE 2004
             :.|.||
Mouse   593 -SELIRE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425
		PDZ_signaling	1562..1640	CDD:238492
		SH3_MPP5	1673..1734	CDD:212969
		Guanylate_kin	1820..1994	CDD:279019	50/183 (27%)
		GuKc	1831..2002	CDD:214504	48/180 (27%)
Lrguk	XP_006506776.1	leucine-rich repeat	131..150	CDD:275380
		internalin_A	<132..>333	CDD:380193
		leucine-rich repeat	151..172	CDD:275380
		leucine-rich repeat	173..194	CDD:275380
		leucine-rich repeat	195..216	CDD:275380
		leucine-rich repeat	217..238	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		leucine-rich repeat	282..300	CDD:275380
		leucine-rich repeat	304..328	CDD:275380
		GMPK	416..537	CDD:238026	34/126 (27%)
		PHA03247	<678..1233	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810