DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and Dlg5

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	2115	Identity:	390/2115 - (18%)
Similarity:	696/2115 - (32%)	Gaps:	577/2115 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 VTSFTSNQITCSSSTMTTATAGGPISAPSLAT---ATTTVPTASSHTTTV----------VAQIE 231
            |.|...:....|||..:..|.|...|.|.|.|   |..||...|.....:          :|...
Mouse   107 VLSIMPSDSESSSSLSSVGTTGKAPSPPPLLTEQQANDTVENLSIQLRLMTRERNELRKRLAFAT 171

  Fly   232 HGAS--------------ALVSAAVAAATAADRNANSTTSAALKQTANCIGNSTSSLGTTSTTSS 282
            |||:              .|....|.|.:......|..|: |||:... :...|....|
Mouse   172 HGATFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTN-ALKRCEE-VAKETDFYHT------ 228

  Fly   283 QSTSSATGHIYQTSQAQQQQLQQLQQQLAAAAAAGKPLQAKSLLASS---LQHLAEEVDNEDLDD 344
                     ::....:.|.||:.....|  ....||..:.::||..|   ::.|.|| |.:::.|
Mouse   229 ---------LHSRLLSDQTQLKDDVDML--RRENGKLRRERNLLQQSWEDMKRLREE-DQKEIGD 281

  Fly   345 ----------------------DDDVDGANYCGITYISYNNKHAQ---LPTTTLPATTALPAAAA 384
                                  |..:|........|.:...::::   :..:.|.....|.....
Mouse   282 LRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAMHNSDLSRLEQLGEENQ 346

  Fly   385 SL-ATTAAIYQQRQ---QQQHQ-QQQQQQQQPVHHHNHPPTASQLNRATAPAPLQLGGPVNPSFV 444
            .| ..|..:.|||.   |.||| ....::.:.:||        :|::|||...
Mouse   347 RLQKQTEMLTQQRDTAIQLQHQCALSLRRFETIHH--------ELSKATAQNK------------ 391

  Fly   445 DAQTSTSPLMAQQLHSQHADVDAAPPSSSSSSAVVVVERHVHGTTTPKTEYSTAISSG------- 502
            |.|.....|.::....:...|..|..|          |::........:||...:|..
Mouse   392 DLQWEMELLQSELTELRSKQVKTAKES----------EKYKEERDAVYSEYKLIMSERDQVISEL 446

  Fly   503 ---QLQQAFAELQLHSSNN--NATQQQQQHLLLSNNNNSNNSMAAAQTTASLMKNCDLLISN--- 559
               |.:...||.:|.||.:  .|..::.:.|....:..:.::..|.:....|.|.|..|...
Mouse   447 DKLQTEVELAESKLKSSTSEKKAASEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKE 511

  Fly   560 -----NLYPPRRELL---EDVIVHQASDVHSY----------STSASAAAIAS-SSNRSQQQQQQ 605
                 ::...||:..   .|.||.:...:.:.          :.|..|.|:.| ...|.|:....
Mouse   512 ALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVS 576

  Fly   606 QQQHQLLSAAYELQQQQQLQLQQQQQQQNSPTSSISIGRTELLLGDQSLRQDPRGNRRRSGSSIV 670
            ::..:|.|..:..|.:.||:.:.:.:|..:.:|..|...|:.:..:..:.:..|........::
Mouse   577 RELKELNSCVHREQMECQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKAL- 640

  Fly   671 VLDGDDL-----KPCLPDD-------------------------YISGQHHLNHQQQLQLQQQLQ 705
               |.|:     :||.|.|                         .|:....:|..::..::..|.
Mouse   641 ---GFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLN 702

  Fly   706 QQHPLQQQHYRTHSGDIREIDQEMLTMLSVN---------QDNGPHREMAVDCPDTFIARNKTPP 761
            .:..:.....|..|     :..:::|.|.:|         ||:|...|..|......
Mouse   703 GEGAINMVVRRRKS-----LGGKVVTPLHINLSGQKGSRPQDSGISLENGVYAAAVV-------- 754

  Fly   762 RYPPPRPPQKHKKSTNTTTTTTITALTNNDHANKMLIVAYHSSHQHEQLQQQHPSKTSTTTTTIA 826
                  |.....|..:......|.|:......||.|       ::.|.|     .::...:.|::
Mouse   755 ------PGSPAAKEGSLAVGDRIVAINGIALDNKSL-------NECESL-----LRSCQDSLTLS 801

  Fly   827 LDVATQNLYNQKQQNKLEQIENYENCLQSERNEQHEQQFEQQK--QHQATTAMAATQVAQQQTP- 888
            |........:...||..|.|::.:..|....:....|...::.  ||..:|          ||.
Mouse   802 LLKVFPQSSSWSGQNIFENIKDSDRMLSCRAHGPEVQAHNKRNLLQHNNST----------QTDI 856

  Fly   889 --SHKLQATLSSDPNGNSNSNNNSHIVGISSSSSSNNSSITDDFLCVVDGLYQGRKDTASPSSSA 951
              :.:|:.......:|.|:|..:....|.||..|......|.:     ..|...|.||::.....
Mouse   857 FYTDRLEDRKELGHSGGSSSFLHKPFSGSSSPVSPQACPSTSE-----RSLNSFRSDTSAERGYG 916

  Fly   952 FDEVMSKHTLDSF-------GSIAYRHLHQQHQATSNGNSSSNT-------SNTNSNTNSNTNSN 1002
            ..::.|:..|.||       |::..    ...:....|::|..|       |.:.....|.....
Mouse   917 LVDMRSQRPLLSFETEVGPCGAVEV----PLDKIDPEGSNSGGTWPKAVLGSTSGPEKLSVYKKP 977

  Fly  1003 SNTNGNTSNNTAVSTKTA-----TVTKTGVSSSNSNSNSLNS---------SNS-----SMHTSS 1048
            .........||....:|.     .:...|::.|...|..:.|         |:|     .:.|||
Mouse   978 KQRKSIFDPNTFKRPQTPPKIDYLLPGPGLTHSPQPSKRVGSLTPPKPPRRSDSIKFQHRLETSS 1042

  Fly  1049 SSSGHSSNIASATSSSSATSSSTVPDDLSLAPP--------------------GYEVSQQQQQQH 1093
            .|.......:.:||..||...|..|.:.:.|.|                    .|..:::...:.
Mouse  1043 ESEATLVGSSPSTSPPSAPPPSMDPSEPTHASPPRKARVRIASSYHSEGDGDTSYLPAKKPCDED 1107

  Fly  1094 LVATPVTML--------LPPMAKHRELPVDVPDSFIEMVKTTP----------RYPP--PAHLSS 1138
            |.:..|..|        ..|..:.:..||.:|...:|..:..|          .:.|  |.|.|.
Mouse  1108 LTSQKVDELGQKRRRPKSAPSFRPKISPVVIPAQCLEEQECVPAIGELSPEGQEWSPYSPGHASR 1172

  Fly  1139 RGSLLSNGSASTAHTTLSSMGVAPSPVTATAAAAASASAACATTAVAAAAVSGVADGDARRVADE 1203
            .|:.|       .:....|:|..|..:|                       .|...|...|
Mouse  1173 HGNPL-------LYPNRPSVGTVPRSMT-----------------------PGTTVGSILR---- 1203

  Fly  1204 LNGNAKPVPPPRDHLRVEKDGRLVNCSPAPQLPDRRAPGNASSGSS----GATTHPLQHQQIAQI 1264
                 .|:...|.|       |::.|. :|.:|  |..|:.|...|    |..:..|.|:..:..
Mouse  1204 -----NPIYTVRSH-------RVLPCG-SPPVP--RDAGSQSLSPSVQHQGRLSLDLSHRACSDY 1253

  Fly  1265 VE----------PTLEQLDSIKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPG 1319
            .|          |:..:|.|....|     .:.|..:|.....:.|:.:...|...:..:.:||.
Mouse  1254 SEMRASQGSNSLPSSARLGSSSNLQ-----FKAERIKIPLTPRYPRSVMGSDRGSLSHSECSTPP 1313

  Fly  1320 KAVAQ-------QQQQATLATQVVGVENEAYLPD------EDQPQAEQIDGYGELIAALTRLQNQ 1371
            ::...       .|.|.|.:|    :...|..|.      :|:|..|:        ....::|..
Mouse  1314 RSPLNIDTLSSCSQPQTTAST----LPRIAVNPSSHGERRKDRPFVEE--------PRHVKVQKG 1366

  Fly  1372 LSKSGLSTLAGRVSAAH-SVLASASVAHV--------------LAARTAVLQRRRSRVSGPLHHS 1421
            ....|:|.::|.....: |.:...|:||.              :..|:|..|:.|         .
Mouse  1367 SEPLGISIVSGEKGGVYVSKVTLGSIAHQAGLEYGDQLLEFNGINLRSATEQQAR---------L 1422

  Fly  1422 SLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATG 1486
            .:|.|.|.:.:|.|.|...          |::.    :|.|.::|.|  |:.||          .
Mouse  1423 IIGQQCDTITILAQYNPHI----------HQLN----SHSRSSSHLD--PAATP----------H 1461

  Fly  1487 STLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSAC 1551
            |||....||...:      |.|:.|.:.|      ..|...||......:|..:
Mouse  1462 STLQGSSAGTPEH------PSVIDPLMEQ------DEGPGTPPAKQSASSTRSV----------- 1503

  Fly  1552 FGTLNDQNDNIRIIQIEKSTEPLGATVRNEG-EAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQE 1615
             |....:..:.||:.|:||...||..:.... ..|.:..:.....|:....|..||.|||....:
Mouse  1504 -GDTTKKTPDPRIVFIKKSQLDLGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLD 1567

  Fly  1616 LRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFD- 1679
            :|.:||.:|          ...::.|..|............:::.||.|   |:  .::||.:|
Mouse  1568 MRSRTVEDV----------YVEMLKPKDSLRLKVQYRHEEFTRVKGLPG---DS--FYIRALYDR 1617

  Fly  1680 ---YDPEDDLYIPCRELGISFQKGDVLHVISREDP------NWWQAYREGEEDQTL-AGLIPSQS 1734
               .:||           :||:|.|:|:|   :|.      ..|.|::..|..|.: .|.|||:.
Mouse  1618 LAEVEPE-----------LSFKKDDILYV---DDTLPQGVFGSWMAWQLDENAQKIQRGQIPSKY 1668

  Fly  1735 FQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCAR---KGRKKKKKASSEAGYPLYATTAPD 1796
            ...|..:.:|:::|.        ||.:.:|..:....|   :.:.|.|::.|:.|..|.|.   |
Mouse  1669 VMDQEFSRRLSMSEV--------KDDNTAKTLSAAARRSFFRRKHKHKRSGSKDGKDLLAL---D 1722

  Fly  1797 ETDPEEILTYEE-VALYYPR-----ATHKRPIVLIGPPNIGRHELRQRLMADSERFSAAVPHTSR 1855
            ....:.|..:|: |:|.|.|     .|..||::|:||            :.|          ..:
Mouse  1723 TFSNDSIPLFEDSVSLAYQRVQKVDCTSLRPVLLLGP------------LLD----------VVK 1765

  Fly  1856 ARREGEVPG------VDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVL 1914
            .....|.||      ::....::||.|..:....||::......:..|::.:|:.:....:.|:|
Mouse  1766 EMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLL 1830

  Fly  1915 NLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKK----LRNGEPFKEEELKDIIATARDMEARWG 1975
            ::.|.:::.|....:.|.|:.:...|...:::::    ||  :...:...|:...||:.::..:.
Mouse  1831 DIAPHAIERLHHMHIYPIVIFIRYKSAKHIKEQRDPVYLR--DKVTQRHSKEQFETAQKIDQEYS 1893

  Fly  1976 HLFDMIIINNDTERAYHQLLAEINSLEREPQWVPA 2010
            ..|..::..........|:||.::..:.:..|:||
Mouse  1894 RYFTGVVQGGALSSICTQILAMVSQEQSKVLWIPA 1928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	9/42 (21%)
		PDZ_signaling	1562..1640	CDD:238492	19/78 (24%)
		SH3_MPP5	1673..1734	CDD:212969	20/71 (28%)
		Guanylate_kin	1820..1994	CDD:279019	29/183 (16%)
		GuKc	1831..2002	CDD:214504	27/180 (15%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141	17/84 (20%)
		Smc	<141..564	CDD:224117	83/472 (18%)
		PDZ_signaling	625..712	CDD:238492	10/90 (11%)
		PDZ_signaling	<741..800	CDD:238492	12/84 (14%)
		PDZ	1357..1439	CDD:214570	17/98 (17%)
		dbPDZ_assoc	1437..1512	CDD:374667	23/124 (19%)
		PDZ	1513..1594	CDD:214570	21/90 (23%)
		SH3_DLG5	1610..1672	CDD:212794	20/75 (27%)
		GuKc	1744..1920	CDD:214504	33/199 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810