DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sdt and Pdzd2

DIOPT Version :9

Sequence 1:NP_001033835.2 Gene:sdt / 44861 FlyBaseID:FBgn0261873 Length:2020 Species:Drosophila melanogaster
Sequence 2:NP_001074533.1 Gene:Pdzd2 / 68070 MGIID:1922394 Length:2796 Species:Mus musculus


Alignment Length:2416 Identity:429/2416 - (17%)
Similarity:723/2416 - (29%) Gaps:835/2416 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 VEGKIKLY-------GSPPDRDNLEVGDEILEVNGLTLENISRTEVIRHIHDCIKSCTICLRVRK 103
            |.|::.::       ||..:...|:.|||||:|||:.::.::..|.| |....|:|....|.||.
Mouse   610 VRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAI-HTFKQIRSGLFVLTVRT 673

  Fly   104 K-------------------------------------------------------------NDS 107
            |                                                             .:.
Mouse   674 KLLSPSLTPCSTPTHMSRSSSPSFNSSGGAPAGGGQDEGGSASLGRKAPGPKDRIVMEVTLNKEP 738

  Fly   108 RLAWDIG-------NSVQDAFVIAVEEHARERLQ-----------------RLAALNRVTPVDIT 148
            |:...||       ||....::.::...:..:::                 |.|||::|..:   
Mouse   739 RVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAI--- 800

  Fly   149 QLSK--------KLQQTKSGTATSQRQDLSFLNESTPIYVTSFTSNQITCSSSTMTTATAGGPIS 205
             |||        .:.:..:...:.|..| ..:..||  |..|..:|         ::.:.|.|:.
Mouse   801 -LSKCPPGPVRLVIGRHPNPKVSEQEMD-EVIARST--YQESKEAN---------SSPSLGTPLK 852

  Fly   206 APSLATATTTVPTASSHTTTVVAQ--IEHGASALVSAAVAAATAADRNANS----------TTSA 258
            :||||...:.:      :.:.::|  :..|..:|....||.:...|...:.          |..:
Mouse   853 SPSLAKKDSLL------SESELSQYFVHDGQGSLSDFVVAGSEDEDHPGSGYETSEDGSLLTVPS 911

  Fly   259 ALKQTANCIGNSTSSLGTTSTTSSQSTSSATGHIYQTSQAQQQQLQQLQQQLAAAAAAGKPLQAK 323
            |.::|.....||..:||      ||..|..                 |.:|:..|..|..| .:.
Mouse   912 AYRETGKARANSLVTLG------SQRGSGL-----------------LHKQVTVARQASLP-GSP 952

  Fly   324 SLLASSL--QHLAEEVDNEDLDDDDDVDGANYCGITYISYNNKHAQLPTTTLPATTALPAAAASL 386
            .:|.:.|  |......|:.|..||:|.||...|                .:||.  .||.....|
Mouse   953 QVLRNPLLRQRRVRCYDSNDGSDDEDFDGEGDC----------------VSLPG--VLPGPGRPL 999

  Fly   387 A---TTAAIYQQRQQQQHQQQQQQQQQPVHHHNHPPTASQLNRATAPAPLQLGGPVNPSFVDAQT 448
            .   |..|:....:.....:|.::.|:|:           :::|.: .|| ||     |.:|:: 
Mouse  1000 VQDDTRFALATSSKSIDVNKQDERLQKPL-----------VSKACS-VPL-LG-----SSLDSE- 1045

  Fly   449 STSPLMAQQLHSQHADVDAAPPSSSSSSAVVVVERHVHGTTTPKTEYSTAISSGQLQ-QAFAELQ 512
                      ||.|......||.::|....|...::..|.:..| |.|.:.||.:|: :..|:.|
Mouse  1046 ----------HSIHGGTAGTPPKAASLPGSVETPKNGPGGSRRK-EMSGSRSSPKLEYRVPADTQ 1099

  Fly   513 LHSSNNNATQQQQQHLLLSNNNNSNNSMAAAQTTASLMKNCDLLISNNLYPPRRELLEDVIVHQA 577
            ...|..|.|...|:                   |.:|:.             |.:.:..:..|  
Mouse  1100 SPRSPENGTSPPQK-------------------TENLVS-------------RHKPVARISPH-- 1130

  Fly   578 SDVHSYSTSASAAAIASSSNRSQQQQQQQQQHQLLSAAYELQQQQQLQLQQQQQQQNSPTSSISI 642
                 |..|.:..|.:.::|....|                      .|:.|......|.:....
Mouse  1131 -----YKRSDAEEAPSETANGPCAQ----------------------DLKVQASSVKDPVAGHQP 1168

  Fly   643 GRTELLLGDQSLRQDPRGNRRRSGSSIVVLDGDDLKPCLPDDYISGQHHLNHQQQLQLQQQLQQQ 707
            |.|        ..::.|||.....||:....|....||.|:   :|               |..:
Mouse  1169 GGT--------AEKELRGNPTPGDSSVPTNCGPASTPCHPN---TG---------------LPTE 1207

  Fly   708 HPLQQQHYRTHSGDIREIDQEMLTMLSVNQDNGPHREMAVDCPDTFIARNKTPPRYPPPRPPQKH 772
            :|         .|...|.              |||.....|.....           ||.|.:..
Mouse  1208 NP---------QGAAPEC--------------GPHPGTGWDGSSDH-----------PPSPGKSR 1238

  Fly   773 KKSTNTTTTTTITALTNNDHANKMLIVAYHSSHQHEQLQQQHPSKTSTTTTTIALDVATQNLYNQ 837
            :...:::.|..:|                      ||:.|  |...|...:....:..:|.:...
Mouse  1239 EVRPDSSETPAVT----------------------EQVLQ--PESLSQPVSPGTSEPESQGVSKM 1279

  Fly   838 K--QQNKLEQIENYENCLQSERNEQHEQQFEQQKQHQATTAMAATQVAQQQT-------PSHKLQ 893
            |  .|..|...|.......|.|.      :........:|..||..::..:|       || .|.
Mouse  1280 KPASQRSLSPREKASALPDSSRT------WAGPGDSTPSTRRAAVPMSIGETRATAIPHPS-LLG 1337

  Fly   894 ATLSSDPNGNSNS-NNNSHIVGIS----------SSSSSNNSSITDDFLCVVDGLYQGRKDTASP 947
            ...|.||:|.|.: ....|.|..|          :|:|...|..........||...|  .|.||
Mouse  1338 QERSRDPSGPSKALETPGHCVPTSLKDRALLEETASASGKLSHAGPSVPVTTDGTLSG--STESP 1400

  Fly   948 SSSAFDEVMSKHTLDSF-GSIAYRHLHQQHQATSNGNSSSNTSNTNSNTNSNTNSNSNTNGNTSN 1011
            .:.          :|.| |......|.|..|   ..:..::.....|.........|:.:|.|..
Mouse  1401 VTD----------IDKFIGEAPEAWLSQSPQ---RADCRTHQDIFESQPPGGAGGGSSHHGKTGG 1452

  Fly  1012 NTAVSTKTATVTKTGVSSSN------SNSNSLNSSN---SSMHTSSSSSGHSSNIASATSSSSAT 1067
            ..:......|...:.:.|.:      .|.|.||:.:   ||.|....|....|::......||:.
Mouse  1453 TGSPPPPQWTFQPSVLDSVHPDKQLAGNKNFLNNYSRNFSSFHEDGVSEPSPSSMYGDAEDSSSD 1517

  Fly  1068 SSSTVPDDLSL------APPGYEVSQQQ-------QQQHLVA------TPVTMLLPPMAKHRELP 1113
            ..|.|.|..:.      |||.:|.|:::       :|..:.|      |||....|..|....:|
Mouse  1518 PESLVEDPRAAARNNWPAPPSHESSRKEGSSESEDEQIEICAPGGCPETPVPAQAPAQAAGGAVP 1582

  Fly  1114 ------------------------------VDVPDSFIEM----------VKTTPRYPP-----P 1133
                                          ...|.||:::          |:|:..:.|     .
Mouse  1583 SVQQTVREPVGDACEKACFMTGASNTCIPGSSQPFSFLDVSSLEHETWAGVQTSRSHMPGCAEET 1647

  Fly  1134 AHLSSRGSLLSNGSASTAHTT---------------LSSMGVAPSPVTATAAAAASASAACATTA 1183
            ..:||.||::  |.:..:.||               ::.:|   ..:.........|.|:...::
Mouse  1648 LAVSSTGSVV--GDSQPSQTTRPCGNPPFVLRNPDMVNGLG---QDLLDEGTPDKGADASHVMSS 1707

  Fly  1184 VAAAAVSGVADGDARRVADELN----GN-----AKPVPPPRDHLR-----VEKD--GRLVNCSPA 1232
            |.|....|..:|:|  |...|:    ||     .||....|..:.     :.||  |..:.....
Mouse  1708 VYALGAEGPKNGEA--VLANLHIAKGGNLDGLLQKPKTTSRRPIMTWFKDINKDSQGAHLQSKSE 1770

  Fly  1233 PQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQN- 1296
            .:.|...|   .|.||.|.|.:|...:.:|....|             ..|::.:|.:.::.:: 
Mouse  1771 KEQPSMLA---MSPGSKGNTVNPSHRKGMAVPKSP-------------PPRQKSQENKDLSPKSP 1819

  Fly  1297 -EFLRN--SLRGSRKLKALQD---------TATPGKAVAQQQQQATLATQVV------GVENEAY 1343
             |.|.|  ..:||.|||.|..         .|:|.|......:::..:.|..      .|.:..:
Mouse  1820 VETLSNCQKPKGSPKLKRLNSKSKASPEAPVASPAKGGRTDHRKSLPSPQAAHKMLSKAVSHRLH 1884

  Fly  1344 LPDEDQPQAEQIDGYGEL-------------IAALTRLQNQLSKSGLSTLA-------------- 1381
            :.|:::|:    :..|:.             :||...|:...|.:.:.|:.              
Mouse  1885 IADQEEPK----NTAGDTSKPPQCVPESKPPLAASGSLRTSASDTSIRTITSPLTSPKPLPEQGA 1945

  Fly  1382 ----------------------------GRVSAAHSVLASASVAHVLAARTAVLQRRR---SRV- 1414
                                        |:|..|:|...|.|.:....|...|.|.::   ||| 
Mouse  1946 NNRFHMAVYLESDTSCPATSRPPRYGPEGKVPHANSGSVSPSASRTNIALAGVRQSKQFTHSRVD 2010

  Fly  1415 ------SGPLHHSSLGLQKDIVELLTQSNTAAAIEL--------------------GNLLTS--- 1450
                  :.|...|..|.:|...:.|.::|....||:                    |..||.   
Mouse  2011 LVLTEAAQPQGISEKGTEKMASDPLERTNQLKIIEISSERMPKNACGDKPPGSDRKGGFLTQSNC 2075

  Fly  1451 HEMEGLLLAHD-----------------------------RIANHTDGTPSPTPTPTPAIGAATG 1486
            .|...:.|...                             |:|:.:...|. .|:..|.......
Mouse  2076 QEKSSVRLRQSAESSPKQPHFPPSQASQGEQEMRWSYSMARLASSSPSAPQ-LPSKMPDYSQGKS 2139

  Fly  1487 STLSSPVAGPKRNLGMVV----PPPVVPPPLAQRGAMPLP-------RGESPPPVPMPPLATMPM 1540
            |.:.:.|..||..:.:.:    ||...|.|..:..:||..       .|.|||.....|......
Mouse  2140 SQMPASVGVPKNGVPVGLAGEEPPYFTPRPATRTYSMPAQFSSHFGREGLSPPSPSHSPQDPQVT 2204

  Fly  1541 SMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGEAVVIGRIVRGGAAEKSGLL--- 1602
            :|..:|...:..|..|:|.        ..|.:||..|:||. ..|.:|.:  ....|.|||:   
Mouse  2205 AMSGSLSEKSAKGVTNEQG--------VYSVKPLLETLRNP-PPVDVGDV--SAVPEASGLIPDK 2258

  Fly  1603 ---------------HEGDEILEVNGQELRGKTVNEVC--ALLGAMQGTLTFLIVPAGSPPSVGV 1650
                           ||......|   :.|.|:...:.  ....|...|..||.|.:..|.:...
Mouse  2259 LKVTRRHYYCEQSWPHESTSFFSV---KQRIKSFENLANSDRPAAKSATSPFLSVSSKPPVNRRS 2320

  Fly  1651 MGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQ 1715
            .|..|       .|...|.....:|.......|:..........::.....|...:||::|.  :
Mouse  2321 SGSIT-------SGRPSDGTARSLRRSLSSCSENQSEASSLLPQMTKSPSSVTLTVSRQNPP--E 2376

  Fly  1716 AYREGEEDQTLAGLIP--------SQSFQHQRETMKLAIAEEAGLARSR---------------- 1756
            ...:|........|:|        |.:...:|....:..|:.:.::||:                
Mouse  2377 TNNKGHSPDPKKSLVPVGIPISTGSPASPIKRNKSSVRHAQPSPVSRSKLQELRALSMPDLDKLC 2441

  Fly  1757 -GKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVAL--------- 1811
             |:|.|.|.||.|...:.....::...|.|       |:|..:...........|.         
Mouse  2442 SGEDYSASPGAVLFRTQLEITPRRSQGSPA-------TSPASSPARGHADVNGSAFLSCPVNGGN 2499

  Fly  1812 -YYPRATHKRPIVLIGP------------------------PNIGRHELRQRLMADSERFSAAVP 1851
             .||:. :..|.|..|.                        .::|..:..|.:::.....|..:|
Mouse  2500 RVYPKG-NSSPTVPTGSREWGESLRAMPSGKSWSVNLDQLLASVGYQQRLQAVLSLVGSKSPILP 2563

  Fly  1852 HTSRARREGE----------------------VPGVDYH---FITRQAFEADILARR-FVEHGEY 1890
            ....|:.:.|                      ..|.|..   .:..:.|...:.::. .|..|::
Mouse  2564 LIQEAKAQSENKEDICFIVLNKKEGSGLGFSVAGGADVEPESVLVHRVFSQGVASQEGTVSQGDF 2628

  Fly  1891 EKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLR-----QKKLR 1950
            ..:..||||..:.             |.:..|:|..::|..:|:::.....|:.|     :....
Mouse  2629 LLSVNGTSLAGLS-------------HSEVTKVLHQAELHKHVLMIIKKGNDQPRPSFRQEPPSA 2680

  Fly  1951 NGE-PFKEEEL 1960
            ||: ||....|
Mouse  2681 NGKAPFPRRTL 2691

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sdtNP_001033835.2 PDZ_signaling <54..102 CDD:238492 17/47 (36%)
L27 1423..1466 CDD:295425 13/94 (14%)
PDZ_signaling 1562..1640 CDD:238492 21/97 (22%)
SH3_MPP5 1673..1734 CDD:212969 10/68 (15%)
Guanylate_kin 1820..1994 CDD:279019 30/197 (15%)
GuKc 1831..2002 CDD:214504 27/162 (17%)
Pdzd2NP_001074533.1 PDZ_signaling 335..416 CDD:238492
PDZ_signaling 591..672 CDD:238492 19/62 (31%)
PDZ_signaling 729..813 CDD:238492 13/87 (15%)
PHA03307 1050..>1355 CDD:223039 78/457 (17%)
PHA03247 <1197..1562 CDD:223021 86/462 (19%)
PDZ_signaling 2581..2663 CDD:238492 14/94 (15%)
PDZ 2709..2791 CDD:214570
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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