DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and PALS1

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_071919.2	Gene:	PALS1 / 64398	HGNCID:	18669	Length:	675	Species:	Homo sapiens

Alignment Length:	831	Identity:	326/831 - (39%)
Similarity:	443/831 - (53%)	Gaps:	199/831 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1217 HLRVEKDGRLVN---CSPAPQLPDRR----APGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDS 1274
            |:..|.|..:.|   .||......|.    .||:.     |....|::..          .||:.
Human     9 HVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDL-----GTRMMPIRRS----------AQLER 58

  Fly  1275 IKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVE 1339
            |::.||.:|||||||   .::.|.   .|..|.:||.|  ...|.|               .|::
Human    59 IRQQQEDMRRRREEE---GKKQEL---DLNSSMRLKKL--AQIPPK---------------TGID 100

  Fly  1340 NEAYLPDE----DQPQ-AEQIDGYGELIAALTRLQNQL----SKSGLSTL-----------AGRV 1384
            |..:..:|    :.|. |.:|....:|.::|..:|:.|    |:..:|.|           |.::
Human   101 NPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKI 165

  Fly  1385 SAAHSV-LASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLL 1448
            ..|.:| :..||....|.:....|.:....|..|:||..                  ..||..||
Human   166 HNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKE------------------GQELTALL 212

  Fly  1449 TSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPL 1513
            .:..::.||||||::|..                    .....|:...:           |...:
Human   213 NTPHIQALLLAHDKVAEQ--------------------EMQLEPITDER-----------VYESI 246

  Fly  1514 AQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTE-PLGAT 1577
            .|.|      ||:                                   ::|::|||:.: |||||
Human   247 GQYG------GET-----------------------------------VKIVRIEKARDIPLGAT 270

  Fly  1578 VRNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPA 1642
            ||||.::|:|.|||:|||||||||||||||:||:||.|:|||.||||..||..|.|||||:::|:
Human   271 VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335

  Fly  1643 GS---PPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLH 1704
            ..   ||:                   ::| |:||:|||||||.||.|:||||||:||||||:||
Human   336 QQIKPPPA-------------------KET-VIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILH 380

  Fly  1705 VISREDPNWWQAYREGEED-QTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATL 1768
            |||:||||||||||||:|| |.||||:|.:|||.|||.||..|.|          |....|...|
Human   381 VISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEE----------DKEPEKSGKL 435

  Fly  1769 LCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRH 1833
            .||:|.:||:||.       ||.....|:.|.||||||||::||:..|..||||:||||.|.|::
Human   436 WCAKKNKKKRKKV-------LYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQN 493

  Fly  1834 ELRQRLM-ADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGT 1897
            ||||||| .:.:||::|||||:|:||:.||.|.||||::||||||||.|.:|:||||:||..|||
Human   494 ELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGT 558

  Fly  1898 SLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKD 1962
            |::::|.|:.|||||:|:|..||||.||.||||||::.:||||.::||....:.|:..|.|||::
Human   559 SIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELRE 623

  Fly  1963 IIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWV 2013
            ||...|:||...||.||..|:|:|.::||.:||..||.|:.||||||:.|:
Human   624 IIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWL 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	11/42 (26%)
		PDZ_signaling	1562..1640	CDD:238492	53/78 (68%)
		SH3_MPP5	1673..1734	CDD:212969	49/61 (80%)
		Guanylate_kin	1820..1994	CDD:279019	99/174 (57%)
		GuKc	1831..2002	CDD:214504	95/171 (56%)
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	1..345		128/482 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		6/24 (25%)
		Interaction with PARD6B. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	21..140		37/156 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..78		12/39 (31%)
		L27_N	123..170	CDD:401122	9/46 (20%)
		Interaction with LIN7C. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	181..243		18/110 (16%)
		L27	189..237	CDD:197794	16/85 (19%)
		PDZ_signaling	254..333	CDD:238492	53/78 (68%)
		SH3_MPP5	349..411	CDD:212969	49/61 (80%)
		GuKc	491..661	CDD:214504	94/169 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151377
Domainoid	1	1.000	215	1.000	Domainoid score	I2716
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9512
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2106
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		oto90420
orthoMCL	1	0.900	-	-		OOG6_107065
Panther	1	1.100	-	-	LDO	PTHR23122
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3662
SonicParanoid	1	1.000	-	-		X4595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.690