DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and Dlg2

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_038945240.1	Gene:	Dlg2 / 64053	RGDID:	619895	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	1016	Identity:	226/1016 - (22%)
Similarity:	363/1016 - (35%)	Gaps:	309/1016 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1261 IAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQNE------FLRNSLRGSRKLKALQDTATPG 1319
            |.:..|.||  |:|.|..::::    ||..::||:.|      ..|:||:.|.:|..........
  Rat    52 IQEFYEVTL--LNSQKSCEQKI----EEANQVAQKWEKTLVLDLCRDSLQKSSELTGCSGPKENA 110

  Fly  1320 KAVAQQ---------------QQQATLATQVVGVENEAYLP----------DEDQP--------- 1350
            ..:.|.               |.|.....|...||..|::|          |||.|
  Rat   111 SYIEQNKENQFFENETEEKTCQNQGKCPAQNCSVEAPAWMPVHHCSKYRYQDEDGPHDHSLPRLT 175

  Fly  1351 -----------------QAEQIDGY-------------------------------GELIAALTR 1367
                             |.|.:.||                               .|:......
  Rat   176 HEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEE 240

  Fly  1368 LQNQLSKSGLS-TLAGRVSAAH----------SVLASASVAH--VLAARTAVLQRRRSRVSGPLH 1419
            :..:...|||. ::||.....|          .::...:.|.  .|.....:|:.....||...|
  Rat   241 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSH 305

  Fly  1420 HSSLGLQKD---IVELLTQS-----NTAAAIEL------------GNLLTSH------------- 1451
            ..::...|:   ||.|..:.     .|...|:|            |.:...|
  Rat   306 SKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 370

  Fly  1452 -----EMEGLLLAHDRI----------ANHTDGTPSPTPTPTPA---IGAATGSTLSSPVAGPKR 1498
                 :.:|.|...||:          ..|.:.......|....   :|..|...::.|...|
  Rat   371 DGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPP-- 433

  Fly  1499 NLGMVVPPPVVP----------------PPLAQRGAMPLPR--------GESPPPV--------- 1530
            ::.....||:..                ||::.....|:|:        ...|.||
  Rat   434 DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDDYTRPPEPVYSTVNKLCD 498

  Fly  1531 -PMPPLATMPMSMPVNLPMSACF-----GTLNDQN-------------------------DNIRI 1564
             |..|....|:....:..:|..:     |.|.|.:                         ...|.
  Rat   499 KPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQPSVTLQRAISLEGEPRK 563

  Fly  1565 IQIEKSTEPLGATV--RNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCAL 1627
            :.:.|.:..||..:  ..:||.:.:..|:.||.|:.||.|..||:||.|||.:|||.:..:..|.
  Rat   564 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAA 628

  Fly  1628 L-GAMQGTLTFLIVPAGSPPSVG------------VMGGTTGSQLAGLGGAHRDTAVLHVRAHFD 1679
            | ||.|   |..|:....|....            :|..:..|....|....:.:  |:|||.||
  Rat   629 LKGAGQ---TVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRS--LYVRAMFD 688

  Fly  1680 YDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYR---EGEEDQTLAGLIPSQSFQHQRET 1741
            ||...|..:|.:  |:||:.||:||||:..|..||||.|   :|:.::  .|:|||:....::|.
  Rat   689 YDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVILDGDSEE--MGVIPSKRRVERKER 749

  Fly  1742 MKLAIAE---EAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDE---TDP 1800
            .:|...:   :.|:..|:|....              |:||.......:|.|......|   :||
  Rat   750 ARLKTVKFNAKPGVIDSKGSFND--------------KRKKSFIFSRKFPFYKNKEQSEQETSDP 800

  Fly  1801 EE-------------------ILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMAD---- 1842
            |:                   ||:||.|.  .....:.||::::||       ::.|:..|
  Rat   801 EQHVSSNASDSESSCRGQEDLILSYEPVT--RQEINYTRPVIILGP-------MKDRINDDLISE 856

  Fly  1843 -SERFSAAVPHTSRARREGEVPGVDYHF-ITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTV 1905
             .::|.:.||||:|.:|:.||.|.|||| |:|:..|.||...:|:|.|:|....||||::::|.|
  Rat   857 FPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 921

  Fly  1906 VASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDM 1970
            ...||.|:|::...::|.|:.:.|.|..:.:.|.||:.|.:...|    ..||:.|.....|..:
  Rat   922 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKR----LTEEQAKKTYDRAIKL 982

  Fly  1971 EARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQ 2011
            |..:|..|..|:..:..|..|:|....|........|:|::
  Rat   983 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSK 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/90 (14%)
		PDZ_signaling	1562..1640	CDD:238492	29/80 (36%)
		SH3_MPP5	1673..1734	CDD:212969	29/63 (46%)
		Guanylate_kin	1820..1994	CDD:279019	58/179 (32%)
		GuKc	1831..2002	CDD:214504	56/176 (32%)
Dlg2	XP_038945240.1	L27_1	2..62	CDD:401120	4/11 (36%)
		MAGUK_N_PEST	157..239	CDD:402306	9/81 (11%)
		PDZ_signaling	240..324	CDD:238492	16/83 (19%)
		PDZ_signaling	333..418	CDD:238492	10/84 (12%)
		PDZ_assoc	420..487	CDD:402299	9/68 (13%)
		PDZ_signaling	561..639	CDD:238492	29/80 (36%)
		SH3_DLG2	676..749	CDD:212965	30/78 (38%)
		Guanylate_kin	835..1013	CDD:395500	60/188 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810