DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Dlg3

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_006257142.1	Gene:	Dlg3 / 58948	RGDID:	68423	Length:	867	Species:	Rattus norvegicus

Alignment Length:	943	Identity:	213/943 - (22%)
Similarity:	361/943 - (38%)	Gaps:	246/943 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1190 SGVADGDARRVADELNGNAKPVPPPRDHLRVEKDGRLVNCSPAPQLPDRRAPGNASSGSSG---- 1250
            :|.:.|.....:..|...|...|.||...::...||.|...|...:|.:..|....||.|.
  Rat    45 NGASSGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKNTPKLNGSGPSWWPEC 109

  Fly  1251 ATTHPLQHQQIA--------QIVEPTL--EQLDSIKKYQEQLRRRREE----------------- 1288
            ..|:...::|.:        :.:||:|  ...|.:.||:|.:..|...
  Rat   110 TCTNRDWYEQASPAPLLVNPEALEPSLSVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPD 174

  Fly  1289 -----------------------EERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQ--- 1327
                                   .:.:.:.||...:.:..||.::||::.....:.|.:::|
  Rat   175 DPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPP 239

  Fly  1328 -------------------QATLATQVVGVENEAYLPDEDQPQAEQIDG---YGELIAAL--TRL 1368
                               ...:..|.:..:|..|:....:..|.|.||   .|:.:.|:  |.|
  Rat   240 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 304

  Fly  1369 QNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELL 1433
            |:...:..:::|..          ::.:.::..|:           .|.||.:.:....|.....
  Rat   305 QDVRHEEAVASLKN----------TSDMVYLKVAK-----------PGSLHLNDMYAPPDYASTF 348

  Fly  1434 TQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIG--AATGSTLSSPVAGP 1496
            |                      .||.:.|::::            ::|  .|..|.::.|.
  Rat   349 T----------------------ALADNHISHNS------------SLGYLGAVESKVTYPA--- 376

  Fly  1497 KRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDN 1561
                     ||.|||....             |:|...||.                  .|....
  Rat   377 ---------PPQVPPTRYS-------------PIPRHMLAE------------------EDFTRE 401

  Fly  1562 IRIIQIEKSTEPLGATV--RNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEV 1624
            .|.|.:.|.:..||..:  ..:||.:.:..|:.||.|:.||.|..||.||.|||..||..|..:.
  Rat   402 PRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 466

  Fly  1625 CALLGAMQGTLTFLIVPAGSPPSVG------------VMGGTTGSQLAGLGGAHRDTAVLHVRAH 1677
            .|.|.....::|  ||....|....            :|..:..|....|..:.:.:  |:|||.
  Rat   467 AAALKRAGQSVT--IVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRS--LYVRAL 527

  Fly  1678 FDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQA---YREGEEDQTLAGLIPSQSFQHQR 1739
            ||||...|..:|.:  |:||..||:||||:..|..||||   ...||.:|  .|:|||:....::
  Rat   528 FDYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQ--IGVIPSKKRVEKK 588

  Fly  1740 ETMKLAIAE---EAGLARSRGKDGSGSKGATLLCAR------KGRKKKKKASSEAGYPLYATTAP 1795
            |..:|...:   ..|:..|.....:..|.:..|..:      |....::|:..|.|  :.:.|:.
  Rat   589 ERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQEKSIQEQG--VTSNTSD 651

  Fly  1796 DET----DPEEILTYEEVA---LYYPRATHKRPIVLIGPPNIGRHELRQRLMAD--SE---RFSA 1848
            .|:    ..:.||:||.|.   ::|     .||::::||       ::.|:..|  ||   :|.:
  Rat   652 SESSSKGQEDAILSYEPVTRQEIHY-----ARPVIILGP-------MKDRVNDDLISEFPHKFGS 704

  Fly  1849 AVPHTSRARREGEVPGVDYHF-ITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKIC 1912
            .||||:|.||:.||.|.|||| ::|:..|.||...:|:|.|::....||||::::|.|...||.|
  Rat   705 CVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHC 769

  Fly  1913 VLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDMEARWGHL 1977
            :|::...::|.|:.:.|.|..:.:.|.|::.|.:...|.    ..|:...|...|..:|..:|..
  Rat   770 ILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQ----TYEQANKIFDKAMKLEQEFGEY 830

  Fly  1978 FDMIIINNDTERAYHQLLAEINSLEREPQWVPA 2010
            |..|:..:..|..|:::...|........|||:
  Rat   831 FTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	5/42 (12%)
		PDZ_signaling	1562..1640	CDD:238492	27/79 (34%)
		SH3_MPP5	1673..1734	CDD:212969	30/63 (48%)
		Guanylate_kin	1820..1994	CDD:279019	57/179 (32%)
		GuKc	1831..2002	CDD:214504	54/176 (31%)
Dlg3	XP_006257142.1	MAGUK_N_PEST	52..148	CDD:287565	21/95 (22%)
		PDZ_signaling	149..226	CDD:238492	8/76 (11%)
		PDZ_signaling	242..328	CDD:238492	13/95 (14%)
		PDZ_assoc	329..403	CDD:287558	22/161 (14%)
		PDZ_signaling	402..480	CDD:238492	27/79 (34%)
		SH3_DLG3	520..586	CDD:212962	31/71 (44%)
		Guanylate_kin	676..854	CDD:279019	59/193 (31%)
		GuKc	687..854	CDD:214504	54/170 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810