DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Mpp4

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_038940071.1	Gene:	Mpp4 / 58808	RGDID:	620016	Length:	636	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	213/731 - (29%)
Similarity:	344/731 - (47%)	Gaps:	160/731 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1318 PGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLS------KSG 1376
            |.:|.|.:.:|:         :..|.|.|||:..:...:....|...|..|..:||      ..|
  Rat    25 PSQAPAGRMRQS---------DRGAELTDEDRALSTAPNPENGLSGILRLLLQELSLFYSRDVHG 80

  Fly  1377 LSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAA 1441
            |..|       :.:|.|..:..:|.....:.:.:..::.....|:.: |..:::|||.:::::..
  Rat    81 LCLL-------YDLLHSPWLQALLKVYDCLQKFKEKKLVPATTHAQI-LSCEVLELLPKASSSPE 137

  Fly  1442 I-ELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVP 1505
            | ||..:|.:...:.||.|||.:
  Rat   138 IQELRQVLQAPHCKALLRAHDTV------------------------------------------ 160

  Fly  1506 PPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKS 1570
                    ||:...||          :|||       |.|:|         |..:.:|.:.:.|:
  Rat   161 --------AQKDFEPL----------LPPL-------PDNIP---------DSEEAMRTVCLVKN 191

  Fly  1571 TEPLGATVRNE---GEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQ 1632
            .:|||||::..   |: :::.|::.||..|:||||:.||:::||||..:.|....:|..:|....
  Rat   192 QQPLGATIKRHEITGD-ILVARVIHGGLVERSGLLYAGDKLVEVNGVPVEGLDPEQVIHILAMSC 255

  Fly  1633 GTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISF 1697
            ||:.|.::|..:||   |...||                ::|||..||.|::|..|||.:.|:.|
  Rat   256 GTIMFKVIPVSAPP---VSSQTT----------------VYVRAMIDYWPQEDPDIPCMDAGLPF 301

  Fly  1698 QKGDVLHVISREDPNWWQAYREGEEDQTLAGLIPSQSF--QHQRE-TMKLAIAEEAGLARSRGK- 1758
            .|||:|.::.:.|..|||| |:..:....||||||...  :.||| ...........|..:|.|
  Rat   302 LKGDILQIVDQSDALWWQA-RKISDLAICAGLIPSNHLLKRKQREFWWSQPYQPHTCLKSTRSKE 365

  Fly  1759 ----DG-----SGSKGATLLCARKGRKKKKKASSEAGYPLY-ATTAPDETDPEEILTYEEVALYY 1813
                ||     :|.:.:..||.||....:..|:.......| |..||          ||||..|.
  Rat   366 EFVGDGQQFFIAGFRRSMRLCRRKSHFSQLHANMRCTCSCYSAVGAP----------YEEVVRYQ 420

  Fly  1814 PRATHK-RPIVLIGPPNIGRHELRQRLM-ADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFE 1876
            .:...| |.|||:||..:|.:|||::|: .:...|.:|||||:|:.:..|:.|.:||:::|:.||
  Rat   421 RQPADKHRLIVLVGPSGVGVNELRRQLIGCNPSCFQSAVPHTTRSPKSYEMDGREYHYVSRETFE 485

  Fly  1877 ADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSL 1941
            :.:...|.:|.|||:...||||:.|:..|:..|||||::|.||.::|.|..:|||||:.:.|||:
  Rat   486 SLMYGHRMLEFGEYKGHLYGTSVNAVLAVLDEGKICVMDLEPQDIQLARTRELKPYVIFIKPPSM 550

  Fly  1942 DKLRQKKLRNGE---------PFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAE 1997
            ..:|..: ||.:         .||:|:|:::...|:.||:::|..||.:|:|::.:.|..|||:.
  Rat   551 SSMRHSR-RNAKIITDYFVDMKFKDEDLQEMEELAQKMESQFGQFFDHVIVNDNLQDARAQLLSA 614

  Fly  1998 INSLEREPQWVPAQWV 2013
            |...|.|.||||..||
  Rat   615 IQKAEEELQWVPEAWV 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/43 (30%)
		PDZ_signaling	1562..1640	CDD:238492	28/80 (35%)
		SH3_MPP5	1673..1734	CDD:212969	28/60 (47%)
		Guanylate_kin	1820..1994	CDD:279019	70/183 (38%)
		GuKc	1831..2002	CDD:214504	68/180 (38%)
Mpp4	XP_038940071.1	L27	<79..114	CDD:197794	6/41 (15%)
		L27	124..171	CDD:197794	16/106 (15%)
		PDZ_signaling	184..263	CDD:238492	28/79 (35%)
		SH3_MPP4	277..337	CDD:212967	28/60 (47%)
		Guanylate_kin	428..618	CDD:395500	74/190 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820