DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and MPP4

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_149055.2	Gene:	MPP4 / 58538	HGNCID:	13680	Length:	637	Species:	Homo sapiens

Alignment Length:	727	Identity:	212/727 - (29%)
Similarity:	345/727 - (47%)	Gaps:	179/727 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1362 IAALTRLQNQLSK------SGLSTLAGR----VSAAHSVLASASVAHVLAARTAVLQRRRSRVSG 1416
            ::..|..||.||:      ..||...||    |...:.:|.|..:..:|.....:.:.:..::..
Human    18 LSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVP 82

  Fly  1417 PLHHSSLGLQKDIVELLTQSNTAAAI-ELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPA 1480
            ...|:.: |..::||||.::.|:..| ||..:|.:...:.||.|||.|
Human    83 ATPHAQV-LSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTI----------------- 129

  Fly  1481 IGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVN 1545
                                             ||:...||          :|||       |.|
Human   130 ---------------------------------AQKDFEPL----------LPPL-------PDN 144

  Fly  1546 LPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNE---GEAVVIGRIVRGGAAEKSGLLHEGDE 1607
            :|         :..:.:||:.:.|:.:|||||::..   |: :::.||:.||.||:||||:.||:
Human   145 IP---------ESEEAMRIVCLVKNQQPLGATIKRHEMTGD-ILVARIIHGGLAERSGLLYAGDK 199

  Fly  1608 ILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVL 1672
            ::||||..:.|....:|..:|...:||:.|.:||...||        ..||           .::
Human   200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPP--------VNSQ-----------QMV 245

  Fly  1673 HVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTLAGLIPSQSF-- 1735
            :|||..:|.|::|..|||.:.|:.|||||:|.::.:.|..|||| |:..:..|.|||:||...
Human   246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQA-RKISDPATCAGLVPSNHLLK 309

  Fly  1736 QHQRE---------------TMKLAIAEEAGL-----------------ARSRGKD---GSGSK- 1764
            :.|||               |:.:::.||..:                 ..|..|:   |.|.|
Human   310 RKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKF 374

  Fly  1765 ------GATLLCARKGRKKKKKASSEAGYPLY-ATTAPDETDPEEILTYEEVALYYPRATHK-RP 1821
                  .:..||.||.......||.......| |..||          ||||..|..|.:.| |.
Human   375 FIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAP----------YEEVVRYQRRPSDKYRL 429

  Fly  1822 IVLIGPPNIGRHELRQRLMA-DSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFV 1885
            |||:||..:|.:|||::|:. :...|.:|||||:|.::..|:.|.:||:::::.||..|.:.|.:
Human   430 IVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRML 494

  Fly  1886 EHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLR 1950
            |:|||:...||||::|::||:..|||||::|.||.::.:|..:|||||:.:.|.::..::|.: :
Human   495 EYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSR-K 558

  Fly  1951 NGE---------PFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQ 2006
            |.:         .||:|:|:::...|:.||.::|..||.:|:|:....|..|||:.|...:.|||
Human   559 NAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQ 623

  Fly  2007 WVPAQWVHNNRD 2018
            ||||.|:.::.:
Human   624 WVPATWISSDTE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	16/43 (37%)
		PDZ_signaling	1562..1640	CDD:238492	31/80 (39%)
		SH3_MPP5	1673..1734	CDD:212969	28/60 (47%)
		Guanylate_kin	1820..1994	CDD:279019	67/183 (37%)
		GuKc	1831..2002	CDD:214504	65/180 (36%)
MPP4	NP_149055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		0/3 (0%)
		L27	30..83	CDD:197794	8/52 (15%)
		L27	90..140	CDD:197794	20/109 (18%)
		PDZ_signaling	153..232	CDD:238492	31/79 (39%)
		SH3_MPP4	246..306	CDD:212967	28/60 (47%)
		Guanylate_kin	428..618	CDD:331880	71/190 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820