DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and mpp3a

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_021330373.1	Gene:	mpp3a / 572079	ZFINID:	ZDB-GENE-130530-555	Length:	613	Species:	Danio rerio

Alignment Length:	681	Identity:	209/681 - (30%)
Similarity:	337/681 - (49%)	Gaps:	159/681 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1417 PLHHSSLGLQKDIVELLTQSNTAA-----AIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPT 1476
            |:..:..||.:.:..|.:|....|     .:.|.::.:...:..|:..|:::..:      ...:
Zfish     6 PVLSAGGGLHETLALLTSQLRPDANHKEDMVFLRDVFSERSLSCLMKIHEKLRQY------EKQS 64

  Fly  1477 PTPAIGAATGSTLSSPVA-----GP-----KRNLGMVVPPPV-----VPPPLAQRGAMPLPRGES 1526
            |||.:.:|  |||:..||     ||     |..|.::..|.:     |...:||:...|:
Zfish    65 PTPVLHSA--STLAEDVAEELQSGPMSVEEKELLHLLTSPHLKAVLSVHDTVAQKNFDPV----- 122

  Fly  1527 PPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGE--AVVIGR 1589
                 :|||   |......|           ..::::|:::.|:.||||||:|.:..  ||::.|
Zfish   123 -----LPPL---PDDFEDEL-----------DEESVKIVRLVKNKEPLGATIRRDESTGAVIVAR 168

  Fly  1590 IVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGT 1654
            |::||||::|||:|.|||:.||||..:..|..:|:..||...||::|..|:||.....
Zfish   169 IMKGGAADRSGLVHVGDELREVNGSSVMHKRPDEISQLLSQSQGSITLKIIPAIKEED------- 226

  Fly  1655 TGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYRE 1719
                       ......:::||.|||.|.:|...||:|.|:.|::||||.|:|::|..||||.|.
Zfish   227 -----------KLQENKVYMRALFDYTPLEDKATPCQEAGLPFKRGDVLQVVSQDDQTWWQAKRI 280

  Fly  1720 GEEDQTL-AGLIPSQSFQHQR-------------ETMKLAIAEE--------------------- 1749
            |  |..| |||:||:.||.:|             ::.|.|:.::
Zfish   281 G--DCNLRAGLVPSKQFQERRLAYRIKMGTLQNSKSPKKAVYDQGCDKEDCDCEGYFNGQYIVSS 343

  Fly  1750 -------------------AGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAP 1795
                               |||.||               .|..||.::.:|.||       ...
Zfish   344 KCNAVAPSCGQVFSWDFYSAGLRRS---------------FRLSRKDRRGSSGEA-------NVS 386

  Fly  1796 DETDPEEILTYEEVALYYPRATHK-RPIVLIGPPNIGRHELRQRLMADS-ERFSAAVPHTSRARR 1858
            |:.| .:.||||||..|..|:..: |.:||||......:||:|:::|:: .|::.|||||:|.::
Zfish   387 DQND-TDFLTYEEVTRYQQRSNERPRLVVLIGSLGARINELKQKVIAENPHRYAVAVPHTTRPKK 450

  Fly  1859 EGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKL 1923
            ..|..||:|||:|:|||:||....:|:|:|||::..||||:||||:|.|..|:|::::.|::||.
Zfish   451 SHEKEGVEYHFVTKQAFDADAQNNKFIEYGEYKENLYGTSIEAIRSVQAKNKMCLVDVQPEALKA 515

  Fly  1924 LRASDLKPYVVLVAPPSLDKLRQKKLR----NGE--PFKEEELKDIIATARDMEARWGHLFDMII 1982
            ||.::.||||:.|.|...:..|::...    .||  ...||:|:::..:|:.::.::|||.|.::
Zfish   516 LRTAEFKPYVIFVKPKIPESRRRRSAATSPGGGEHGRITEEDLQEMRLSAQQIDQQYGHLVDRVL 580

  Fly  1983 INNDTERAYHQLLAEINSLEREPQWVPAQWV 2013
            |..||..|..:|.:.:..||||..|||..||
Zfish   581 IKEDTASASTELRSILERLERETFWVPISWV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	8/47 (17%)
		PDZ_signaling	1562..1640	CDD:238492	35/79 (44%)
		SH3_MPP5	1673..1734	CDD:212969	32/61 (52%)
		Guanylate_kin	1820..1994	CDD:279019	71/180 (39%)
		GuKc	1831..2002	CDD:214504	67/177 (38%)
mpp3a	XP_021330373.1	L27	15..66	CDD:308467	6/56 (11%)
		L27	73..123	CDD:308467	14/59 (24%)
		PDZ_signaling	139..219	CDD:238492	35/79 (44%)
		SH3	234..295	CDD:327375	32/62 (52%)
		GuKc	426..597	CDD:214504	66/170 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820