DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and dlg5a

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_005156738.1	Gene:	dlg5a / 569065	ZFINID:	ZDB-GENE-030131-3149	Length:	1961	Species:	Danio rerio

Alignment Length:	2138	Identity:	409/2138 - (19%)
Similarity:	714/2138 - (33%)	Gaps:	595/2138 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 SSHTTTVVAQIE----HGASALVSAAVAAATAADRNANSTTSAALKQTANCIGNSTSSLGTTSTT 280
            |.|...:...:|    |..|||.|   .....||.::.||.|  :..|......|:|||.:..|.
Zfish    67 SDHFLELCVALEKTYPHLYSALFS---NGGGPADHHSGSTYS--VLSTMPSDSESSSSLSSVGTK 126

  Fly   281 SSQ----------STSSATGHIYQTSQAQQQQLQQLQQQLAAAAAA---------GKP------L 320
            :|.          ::.|....::|..|..::: .:|:::||.|:..         .||      |
Zfish   127 ASSPPPALSDTRPASDSLDTILFQLKQVTRER-DELRKRLALASPGTTFDDCRPNSKPGHDYERL 190

  Fly   321 QAKSLLA-SSLQHLAEEVDNEDLDDDDDVDGANYCGITYISYNNKHAQLPTTTLPATTALPAAAA 384
            :.:...| :.||.|..:........::.|..|:|       |:.:|::|    |...|.|.....
Zfish   191 KTQCTKAMADLQSLQNQHTKTLKRCEEAVKEADY-------YHIQHSRL----LSEQTQLKEEME 244

  Fly   385 SL--ATTAAIYQQRQQQQ--------HQQQQQQ------QQQPVHHHNHPPTASQLNRATAPAPL 433
            .|  ..|....:....:|        |.:.|::      |||.|...|  .::..||:....|..
Zfish   245 VLKRENTKLTREHNHLKQSCEELRRLHSEDQREVADMRLQQQQVIREN--GSSEVLNKLYDTAMD 307

  Fly   434 QLGGPVNPSF----------------------------------VDA---QTSTSPLMAQQLHSQ 461
            :|.| |...:                                  :||   |..|:....||..:.
Zfish   308 KLEG-VKKEYDVLSKRYSEKVSSHNTDLSRLEQVEEENRRLQKQIDALLKQRDTAIQYQQQWSTS 371

  Fly   462 HADVDAAPPSSSSSSAV-VVVERHVHGTTTPKTEYST----AISSG-----QLQQAFAELQLHSS 516
            ....|:.....:.:||. ..::|.:....:..|.|..    |:..|     :....|.|.:|..|
Zfish   372 MRRFDSVQQELNKASAQNKELQREMERLQSEVTRYKNFQLKAVKDGEKYKEERDSVFNEYRLIMS 436

  Fly   517 NNNATQQQ----QQHLLLSN---NNNSNNSMAAAQTTASLMK--NCDLLISNNLYPPRRELLEDV 572
            ..:...::    |..|..:.   .|.|:..|.|::...:|.:  |..|:..:.....|.||||.
Zfish   437 ERDQVIKEVDKLQTELEAAEARLKNTSSERMVASEELEALRQELNSSLVDRDRAICERNELLEK- 500

  Fly   573 IVHQASDVHSYSTSASAAAIASSSNRSQQQQQQQ-------QQHQLLSAAYELQQQQ-------- 622
            ..|:..|........|.|.....:.|.::...::       |:.|||...|:.:|:|
Zfish   501 YCHEVKDKAEAQKELSQACKDIETVREERDVARKERTEAIIQRDQLLREYYQARQKQDSATLDME 565

  Fly   623 ---------QLQLQQQQQQQNSPTSSISIG----------RTELLLGDQSLR---QDPRGNRRRS 665
                     :.|.:...|:.........:.          |.:::...:|:|   .:.|..|.|:
Zfish   566 RANKEIDILRKQCEAMSQELKEAVQEAEVAKCRRDWAFQERDKIVAERESIRTLCDNLRRERDRA 630

  Fly   666 GSSIVVLDGDDLKPCLPD-DYISGQHHLNHQQQLQLQQQLQQQHPLQQQ--HYRTHSGDIREIDQ 727
            .|        ||...|.: |.:..|.:...::..:|:::::.|...:.:  ....||.....||.
Zfish   631 VS--------DLADALRNLDDMRKQRNDAARELKELKEKMESQLDKEARFCQLMAHSSHDSAIDT 687

  Fly   728 EML------TMLSVNQDNGPHREMAVDCPDTFIARNKTPPRYPPP---RPPQKHKKS-------- 775
            :.|      .....::|:...:.|..|     ||.....|..|..   ...:..|.|
Zfish   688 DSLEWETEVVEFEKDRDDMDLKAMGFD-----IAEGVNDPYLPGDCGIFVSRVDKGSIADGRLRV 747

  Fly   776 ------------TNTTTTTTITALTNNDHANKM-----------LIVAYHSS---HQHEQLQQQ- 813
                        ||......|.|:.|......|           |:.:.|.:   |:...:..:
Zfish   748 NDWLLKINDVDLTNKDRKQVIKAVLNGGGLINMVVRRRKSLGGRLVTSVHINLIGHKDAGIALEG 812

  Fly   814 ----------HPSKTSTTTTT---------IALDVATQNLYNQKQQNKLEQIENYENCLQSERNE 859
                      .|:....:.|.         ||||            ||  .:...|..|:..|:
Zfish   813 GVFVAGIAPGSPAAREGSLTIGDRLIAINGIALD------------NK--SLSECEALLRGGRD- 862

  Fly   860 QHEQQFEQQKQHQATTAMAATQVAQQQTPSHKLQATLSSDPNGNSNSNNNSHIVGISSSSSSN-- 922
                          :.|::..:...|.|....:..:|..    ...||...|:..:.|.:|.|
Zfish   863 --------------SLALSLMKFFPQSTSGQNIFESLRE----AEKSNGRIHLTDVHSRNSRNLK 909

  Fly   923 -NSSI-TDDFLCVVDGLYQGRKDTASPSSSAFDE-------VMSKHTL---DSFGSIAYRHLHQQ 975
             |||. ||.:.|...|  :.||..:....|.|.|       .:..:||   ...|.:.|.....|
Zfish   910 HNSSTQTDIYSCDTAG--ERRKTRSDAEESLFSERKVFPISTLHPNTLRPASELGPVRYSASAFQ 972

  Fly   976 HQATSNGNSSSNTSNTNSNTNSNTNSNSNTNGNT--SNNTAVSTKTATVTKTGVSSSNSNSNSLN 1038
            ....:...|......|...|....:|     |.|  .....|:..|.:..:..:..|.....|:.
Zfish   973 EVCYTRSESVGPECVTLETTLEKKHS-----GGTWPKMVVGVAMTTDSPAQLSIYRSPKQRKSIF 1032

  Fly  1039 SSNSSMH--TSSSSSGHSSNIASATSS--------------------SSATSSSTVPDDLSLAPP 1081
            .:::...  |.|.:..|......|.|:                    .|:||.||: ..:|::.|
Zfish  1033 DADTFKRPDTPSKADYHGPQPLKADSAPTPPTPPTRSDSFKFKHKHQGSSTSESTI-SAMSISEP 1096

  Fly  1082 GYE-----------------------VSQQQQQQHLVATPVTMLLPPMAKHRELPVDVP-DSF-- 1120
            ..|                       :.:...::..|..|.....|.: :.|..|.::| .||
Zfish  1097 KQEDRNGNLYFSEGKVLSSRKSCEEDIGRMWAEEPEVKRPRPKSAPAL-RRRMTPQNIPLQSFQS 1160

  Fly  1121 ----------IEMVKTTPRYPPPAHLSSRGSLLS--NGS--ASTAHTTLSSMGVAPSPVTATAAA 1171
                      .||::::|..|   |..|.|.:.:  ||:  .::||     .|:||
Zfish  1161 YSNDGDSVEQREMLRSSPNRP---HRHSVGFVPTSYNGTLPPNSAH-----RGLAP--------- 1208

  Fly  1172 AASASAACATTAVAAAAVSGVADGDARRVADELN-GNAKPVPPPRDHLRVEKDGRLVNCSPAPQL 1235
             .||..|.....|.......|...:...|..::| .:..|.|..:..|.::             |
Zfish  1209 -CSAVTAVMKNPVYMVRSHRVHTNNCPTVVSQINQQHTHPSPQHQGQLSLD-------------L 1259

  Fly  1236 PDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQNEFLR 1300
            ..:|:...:.|..|...:|.....       |:..:|.|....|     .|.|..:|.....:.|
Zfish  1260 SQKRSTDYSESSRSSRASHGTNSL-------PSSARLGSSNNLQ-----YRTERIKIPSTPRYPR 1312

  Fly  1301 NSLRGSRKLKALQDTATPG-------------KAVAQQQQQATLAT----QVVGVENEAYLPDE- 1347
            :.|...|...:..:.::|.             .:.|..|.|.:::|    .|..|..|....|.
Zfish  1313 SILGSDRGSLSHSECSSPSLITPPLSPLNLETSSFASSQSQGSISTLPRISVSPVPTEERRKDRP 1377

  Fly  1348 --DQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAH-SVLASASVAHV---------- 1399
              ::|:...:....|.:             |:|.::|...... |.:...|:||.
Zfish  1378 YLEEPRNVMVHKGAEPL-------------GISIVSGENGGIFVSKVTGGSIAHQAGLEYGDQLL 1429

  Fly  1400 ----LAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAH 1460
                :..|.|..|:.|         ..:|.|.|.:.::.|.| ....:|||             |
Zfish  1430 EYNGINLRNATEQQAR---------LIIGQQCDTITIMAQYN-PHMYQLGN-------------H 1471

  Fly  1461 DRIANH-----TDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMP 1520
            .|.::.     |..||..:.|.||. ..:|..|||      :::.|.:.|......|.....:..
Zfish  1472 SRSSSRLEPVSTQSTPQGSGTATPD-NHSTIDTLS------EQDEGTLTPSSKQTTPTTSPNSFI 1529

  Fly  1521 LPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGEAV 1585
            ....||...||...|.|:..:. |.|.:..|.|.|.    .|.:.::|..:...||      :||
Zfish  1530 RMPSESSKKVPEARLVTVRKTQ-VELGIQLCGGNLR----GIFVERLEDDSPARGA------DAV 1583

  Fly  1586 VIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGV 1650
            |                 .||.|||.....::.|||.|  |.|..::...|..:...........
Zfish  1584 V-----------------PGDMILEYGSVNMKNKTVEE--AYLEMLKPAETVTLRVQHRLDEFNQ 1629

  Fly  1651 MGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISRED--PN- 1712
            :.||.|..             .::||.:|...|       .||.:||:|.|:|:|   :|  ||
Zfish  1630 VKGTPGDG-------------FYIRALYDRVAE-------TELDLSFKKDDILYV---DDTLPNG 1671

  Fly  1713 ---WWQAYREGEEDQTL-AGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARK 1773
               .|.|::..|..|.: .|.|||:....|....:.::.|.        ||.:||.......||:
Zfish  1672 NFGTWMAWQLDENAQKIQRGQIPSKFMMDQEFYRRHSMTEL--------KDETGSSKTLSAAARR 1728

  Fly  1774 G----RKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPR-----ATHKRPIVLIGP-- 1827
            .    :.|.|::||:.|..:.|..| ..||....|. :.|:|.|.|     .|..||::::||
Zfish  1729 SFFRRKHKHKRSSSKDGKDVVALDA-ISTDSIPFLD-DCVSLAYQRVQKIDCTSPRPVLILGPLV 1791

  Fly  1828 -PNIGRHELRQRLMADSE-RFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEY 1890
             |      ::..|:.||. :||..|....:|              ::||.|..:....|:::...
Zfish  1792 DP------VKDMLVKDSPGKFSRCVLEVMKA--------------SQQAIERGVKDFLFIDYKRR 1836

  Fly  1891 EKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKK----LRN 1951
            ...:..|::.:|..:......|:|::.|.:::.|.:..:.|.|:.:...:..:::::|    ||
Zfish  1837 SGHFDVTTVASINEITDKDCHCLLDIAPHAIERLHSVHIYPIVIFIRYKNAKQIKEQKDPIYLR- 1900

  Fly  1952 GEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVP 2009
             :...::..|:....|:.:|..:...|..|:..........|::..::..:.:..|.|
Zfish  1901 -DKVSQKHSKEQFEIAQKIEQDYSKFFTGIVQGGTFPYICTQIVTIVDQEQSKVLWTP 1957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	10/42 (24%)
		PDZ_signaling	1562..1640	CDD:238492	19/77 (25%)
		SH3_MPP5	1673..1734	CDD:212969	23/67 (34%)
		Guanylate_kin	1820..1994	CDD:279019	32/181 (18%)
		GuKc	1831..2002	CDD:214504	28/175 (16%)
dlg5a	XP_005156738.1	CARD	9..88	CDD:260018	5/20 (25%)
		Takusan	128..211	CDD:282652	15/83 (18%)
		Taxilin	295..627	CDD:286771	56/333 (17%)
		RILP-like	338..460	CDD:304877	20/121 (17%)
		SH3BP5	444..648	CDD:283045	39/212 (18%)
		PDZ_signaling	696..783	CDD:238492	15/91 (16%)
		PDZ_signaling	793..866	CDD:238492	13/101 (13%)
		PDZ	1381..1463	CDD:214570	18/104 (17%)
		dbPDZ_assoc	1461..1541	CDD:293216	22/100 (22%)
		PDZ	1541..1623	CDD:214570	26/111 (23%)
		SH3_DLG5	1639..1701	CDD:212794	23/71 (32%)
		Guanylate_kin	1780..1949	CDD:279019	33/190 (17%)
		NK	1794..1950	CDD:302627	28/171 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810