DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and dlg3

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_021328515.1	Gene:	dlg3 / 564081	ZFINID:	ZDB-GENE-050208-93	Length:	940	Species:	Danio rerio

Alignment Length:	885	Identity:	214/885 - (24%)
Similarity:	353/885 - (39%)	Gaps:	226/885 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1233 PQLPD-------RRAPGNASS--GSSGATTHPLQ--HQQIAQIVEPTLEQLDSIKK----YQEQL 1282
            |.:||       :..||.|::  |..|.....|:  ...::::|..  :.::::|:    .:..:
Zfish   171 PHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNDVDVSEVVHS--KAVEALKEAGPVVRLLV 233

  Fly  1283 RRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDE 1347
            |||:...|.|.:.     |.|:|.:.|         |.::|     ..:..|.:..:|..|:...
Zfish   234 RRRQAPPETILEV-----NLLKGPKGL---------GFSIA-----GGIGNQHIPGDNSIYITKI 279

  Fly  1348 DQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRS 1412
            .:..|.|.||         |||.          ..|:.|.::::.. .|.|..|  .|.|:....
Zfish   280 IEGGAAQKDG---------RLQT----------GDRLLAVNNIILQ-DVRHEEA--VAALKNTSD 322

  Fly  1413 RV------SGPLH----------HSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHD 1461
            .|      .||:|          .|||||..               ....::.:|      :.|:
Zfish   323 MVYLKVAKPGPVHLNDMYAPPDYSSSLGLPP---------------AFPTMVDNH------VGHN 366

  Fly  1462 RIANHTDG-TPSPT---PTPTPAIGAATGSTLSSPVAGPKRNLG---MVVPPPVVPPPLAQRGAM 1519
            ....:..| .|.|.   |..||        :..|||  |:..||   .....|:.       .|:
Zfish   367 SSMAYMGGMEPKPVYQPPQVTP--------SRYSPV--PRHMLGEEDFTRAEPIY-------SAI 414

  Fly  1520 PLPRGESPPPVP------MPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATV 1578
            ..|.|::.||.|      ...:...|      .|.:.|...:.......|.|.:.|.:..||..:
Zfish   415 HKPHGDTSPPSPHLCSRGSGDVGCSP------APPALCQSLVPYTGREPRKILLHKGSTGLGFNI 473

  Fly  1579 --RNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVP 1641
              ..:||.:.:..|:.||.|:.||.|..||.||.|||..||..|..:..|.|.....|:|  |:.
Zfish   474 VGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVT--IIA 536

  Fly  1642 AGSPPSVG------------VMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELG 1694
            ...|....            :|..:..|....|..:.:.:  |:|||.||||...|..:|.:  |
Zfish   537 QYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRS--LYVRALFDYDRTRDSCLPSQ--G 597

  Fly  1695 ISFQKGDVLHVISREDPNWWQA---YREGEEDQTLAGLIPSQSFQHQRETMKLAIAEEAGL---A 1753
            :||..||:||||:..|..||||   ...||.:|  .|:|||:.        :.:.|...|:   .
Zfish   598 LSFSYGDILHVINASDDEWWQARLVTPHGESEQ--IGVIPSKK--------RYSTANRPGVEKKE 652

  Fly  1754 RSRGKDGSGSKGATLLCARK---GR---------KKKKKASSEAGYPLY---------------- 1790
            |:|.|.........::.:.:   ||         |:||..:....:|.|
Zfish   653 RARLKTVKFHARTGMIESNREMFGRMNDIRPVKVKRKKSFNLSRKFPFYKSKENIVQELVETEQC 717

  Fly  1791 --ATTAPDET----DPEEILTYEEV---ALYYPRATHKRPIVLIGPPNIGRHELRQRLMAD--SE 1844
              :.|:..|:    ..:.||:||.|   .::|     .||::::||       ::.|:..|  ||
Zfish   718 LTSNTSDSESSSKGQEDTILSYEPVIRQEIHY-----TRPVIILGP-------MKDRVNDDLISE 770

  Fly  1845 ---RFSAAVPHTSRARREGEVPGVDYHFI-TRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTV 1905
               :|.:.||||:|.|||.|:.|.||||: :|:..|.||...:|:|.|::.:..||||:.::|.|
Zfish   771 FPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAV 835

  Fly  1906 VASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDM 1970
            ...||.|:|::...::|.|:.:.|.|..:.:.|.|::.|.:...|.    ..|:...:...|..:
Zfish   836 AERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSVEALMELNKRQ----TYEQANKVFDKAMKL 896

  Fly  1971 EARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPA 2010
            |..:|..|..|:..:..:..|:::...|........|:|:
Zfish   897 EQEFGEFFTAIVQGDSLDEIYNKIKLIIEEQSGPYIWIPS 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	5/42 (12%)
		PDZ_signaling	1562..1640	CDD:238492	28/79 (35%)
		SH3_MPP5	1673..1734	CDD:212969	30/63 (48%)
		Guanylate_kin	1820..1994	CDD:279019	55/179 (31%)
		GuKc	1831..2002	CDD:214504	52/176 (30%)
dlg3	XP_021328515.1	MAGUK_N_PEST	<109..149	CDD:313762
		PDZ_signaling	150..234	CDD:238492	11/64 (17%)
		PDZ_signaling	243..329	CDD:238492	25/126 (20%)
		PDZ_assoc	330..409	CDD:313755	22/109 (20%)
		PDZ	456..540	CDD:214570	29/85 (34%)
		SH3_DLG3	575..639	CDD:212962	31/77 (40%)
		Guanylate_kin	749..927	CDD:279019	57/193 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810